4.8 Review

Anatomy of four human Argonaute proteins

期刊

NUCLEIC ACIDS RESEARCH
卷 50, 期 12, 页码 6618-6638

出版社

OXFORD UNIV PRESS
DOI: 10.1093/nar/gkac519

关键词

-

资金

  1. NIH [R01GM124320, R01GM138997]

向作者/读者索取更多资源

This review explores the completed structural catalog of the four AGO proteins, describing their common features and differences in target specificity, and emphasizing the unique roles of each AGO.
MicroRNAs (miRNAs) bind to complementary target RNAs and regulate their gene expression post-transcriptionally. These non-coding regulatory RNAs become functional after loading into Argonaute (AGO) proteins to form the effector complexes. Humans have four AGO proteins, AGO1, AGO2, AGO3 and AGO4, which share a high sequence identity. Since most miRNAs are found across the four AGOs, it has been thought that they work redundantly, and AGO2 has been heavily studied as the exemplified human paralog. Nevertheless, an increasing number of studies have found that the other paralogs play unique roles in various biological processes and diseases. In the last decade, the structural study of the four AGOs has provided the field with solid structural bases. This review exploits the completed structural catalog to describe common features and differences in target specificity across the four AGOs.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.8
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据