期刊
NUCLEIC ACIDS RESEARCH
卷 50, 期 12, 页码 7134-7146出版社
OXFORD UNIV PRESS
DOI: 10.1093/nar/gkac523
关键词
-
资金
- Agence Nationale de la Recherche (Quarpdiem and G4Access grants)
- Agence Nationale de Recherche contre le SIDA (ANRS)
- Centre National de la Recherche Scientifique (CNRS)
- Institut National de la Sante et de la Recherche Medicale (INSERM)
- Universite de Bordeaux
- ANRS [ECTZ103899]
- ANRS
- Belgian Fonds National de la Recherche Scientifique (FNRS)
- Inserm
The Caenorhabditis elegans model has provided insights into the role of G-quadruplexes in genomic instability. Telomeric sequences in C. elegans show similarities to those in humans, but even small changes in these sequences can have significant effects on the folded G-quadruplex structure. This study determined the structure of the C. elegans telomeric sequence, revealing an intramolecular two G-tetrads basket type G-quadruplex structure with a C-T base pair in the diagonal loop. The findings shed light on the telomeric structure of the widely used C. elegans animal model.
The Caenorhabditis elegans model has greatly contributed to the understanding of the role of G-quadruplexes in genomic instability. The GGCTTA repeats of the C. elegans telomeres resemble the GGGTTA repeats of the human telomeres. However, the comparison of telomeric sequences (Homo sapiens, Tetrahymena, Oxytricha, Bombyx mori and Giardia) revealed that small changes in these repeats can drastically change the topology of the folded G-quadruplex. In the present work we determined the structure adopted by the C. elegans telomeric sequence d[GG(CTTAGG)(3)]. The investigated C. elegans telomeric sequence is shown to fold into an intramolecular two G-tetrads basket type G-quadruplex structure that includes a C-T base pair in the diagonal loop. This work sheds light on the telomeric structure of the widely used C. elegans animal model.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据