A Case Series of Children with Acute Hepatitis and Human Adenovirus Infection

Article Medicine, General & Internal

Clinical Spectrum of Children with Acute Hepatitis of Unknown Cause

Chayarani Kelgeri et al.

Summary: Between January and April 2022, a liver-transplantation center in the U.K. received a total of 44 children with acute hepatitis, with 6 of them undergoing liver transplantation. Most of the children presented with symptoms such as jaundice, vomiting, and diarrhea. Human adenovirus was detected in a majority of the children, although its role in the pathogenesis of the illness is still unknown.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

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Article Immunology

Detection of adenovirus hepatitis and acute liver failure in allogeneic hematopoietic stem cell transplant patients

Yoshiyuki Onda et al.

Summary: HAdV is a significant pathogen in immunocompromised patients, especially after allo-HSCT, and can lead to severe infections such as hepatitis. Unfortunately, HAdV hepatitis is often difficult to diagnose early due to the lack of characteristic symptoms, which can result in rapid progression and high mortality rates.

TRANSPLANT INFECTIOUS DISEASE (2021)

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Article Immunology

Evidence of Severe Acute Respiratory Syndrome Coronavirus 2 Replication and Tropism in the Lungs, Airways, and Vascular Endothelium of Patients With Fatal Coronavirus Disease 2019: An Autopsy Case Series

Julu Bhatnagar et al.

Summary: This study identified cellular targets of SARS-CoV-2 tropism and replication in various tissues, showing direct infection in the lungs and airways. The research provides important insights into COVID-19 pathogenesis and mechanisms of severe outcomes.

JOURNAL OF INFECTIOUS DISEASES (2021)

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Article Gastroenterology & Hepatology

Liver involvement in children with SARS-COV-2 infection: Two distinct clinical phenotypes caused by the same virus

Adriana Perez et al.

Summary: Elevated ALT in children with SARS-CoV-2 is associated with a more severe disease course, including higher rates of multiorgan dysfunction and longer hospitalizations. Male gender and Black race were more likely to be associated with elevated ALT in MIS-C.

LIVER INTERNATIONAL (2021)

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Article Gastroenterology & Hepatology