期刊
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
卷 139, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2022.104736
关键词
Attention; Central executive network; Cognitive control; Default mode network; Salience network
资金
- National Institute on Drug Abuse, USA [U01DA050987]
The anterior insular cortex plays an under-appreciated role in executive processes by acting as a gatekeeper to other brain regions and networks. It is a key hub within the broader midcingulo-insular 'salience network' and orchestrates the activity of other major functional brain networks.
Executive control is a complex high-level cognitive function that relies on distributed brain circuitry. We propose that the anterior insular cortex plays an under-appreciated role in executive processes, acting as a gatekeeper to other brain regions and networks by virtue of primacy of action and effective connectivity. The flexible functional profile of the anterior insular subdivision renders it a key hub within the broader midcingulo-insular 'salience network', allowing it to orchestrate and drive activity of other major functional brain networks including the medial frontoparietal 'default mode network' and lateral frontoparietal 'central executive network'. The microanatomy and large-scale connectivity of the insular cortex positions it to play a critical role in triaging and integrating internal and external multisensory stimuli in the service of initiating higher-order control functions. Multiple lines of evidence scaffold the novel hypothesis that, as a key hub for integration and a lever of network switching, the anterior insula serves as a critical gatekeeper to executive control.
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