期刊
NEUROPHARMACOLOGY
卷 214, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuropharm.2022.109127
关键词
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资金
- Heffter Research Institute
- MicroDoz Therapy Inc.
- Mydecine Innovations Group Inc.
- Unlimited Sciences
- Johns Hopkins Center for Psychedelic and Consciousness Research
- Steven and Alexandra Cohen Foundation
Psilocybin-facilitated psychotherapy has the potential to be effective for a range of mental health conditions in vulnerable populations. However, there is a lack of research in this area. This report highlights the challenges and opportunities of evaluating this therapy in vulnerable populations and provides actionable recommendations for future research.
Psilocybin-facilitated psychotherapy shows potential transdiagnostic efficacy for a range of mental health conditions. Though vulnerable populations bear disproportionate mental health burden, they have been largely neglected in the clinical psilocybin literature. However, if the field is to best respond to the diverse needs of individuals from vulnerable populations, care must be taken to ensure these individuals are represented in the empirical research. This report calls attention to this concern by detailing the challenges and opportunities associated with evaluating psilocybin-facilitated psychotherapy in vulnerable populations. First, we show how working with vulnerable populations must be considered in the context of an often-problematic past and differential exposure to and experience with classic psychedelics. We then provide actionable recommendations for future research testing psilocybin-facilitated psychotherapy in vulnerable populations, including an emphasis on recruitment strategies, the appropriate communication and assessment of subjective effects, building therapeutic alliance, multicultural competence, and flexible study designs. On these premises we call for future work in this area, underscoring that there is vast room for improvement and expansion in this rapidly advancing field of study.
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