3D spatial genome organization in the nervous From and to disease

Chromatin is organized into multiscale three-dimensional structures, including chromosome territories, A/B compartments, topologically associating domains, and chromatin loops. This hierarchically organized genomic architecture regulates gene transcription, which, in turn, is essential for various biological pro-cesses during brain development and adult plasticity. Here, we review different aspects of spatial genome organization and their functions in regulating gene expression in the nervous system, as well as their dysre-gulation in brain disorders. We also highlight new technologies to probe and manipulate chromatin architec-ture and discuss how investigating spatial genome organization can lead to a better understanding of the nervous system and associated disorders.

Automated summary

This review explores the different aspects of spatial genome organization in the nervous system and its role in regulating gene expression, as well as its dysregulation in brain disorders. It also highlights new technologies used to study and manipulate chromatin architecture, and discusses the potential of investigating spatial genome organization for a better understanding of the nervous system and associated disorders.