Protecting against summation of pain

Temporal summation in the spinal cord is linked to pathological pain. In a translational genetic association study in this issue of Neuron, Trendafilova et al. (2022) identify the sodium-calcium exchanger 3 as a negative regulator of temporal summation and hypersensitivity via its modulation of calcium homeostasis.

Automated summary

This study identifies the sodium-calcium exchanger 3 as a negative regulator of temporal summation and hypersensitivity in the spinal cord, linking it to pathological pain through its modulation of calcium homeostasis.