☆ 4.7 Article

Deuterium metabolic imaging and hyperpolarized 13C-MRI of the normal human brain at clinical field strength reveals differential cerebral metabolism

NEUROIMAGE (2022)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Radiology, Nuclear Medicine & Medical Imaging

Enhancing the spatial resolution of hyperpolarized carbon-13 MRI of human brain metabolism using structure guidance

Matthias J. Ehrhardt et al.

Summary: The proposed method enhances the 3D resolution of C-13-MRI by utilizing structural information from H-1-MRI. Validation was conducted using in silico, in vitro, and in vivo data, showing that 3D super-resolution outperforms 2D approaches, revealing hidden information and improving anatomical definition in metabolic imaging.

MAGNETIC RESONANCE IN MEDICINE (2022)

添加到收藏夹

Article Mathematical & Computational Biology

Four features of temporal patterns characterize similarity among individuals and molecules by glucose ingestion in humans

Suguru Fujita et al.

Summary: Oral glucose ingestion induces systemic changes in blood metabolites and hormones related to glucose, amino acids, and lipids. This study measured the temporal patterns of 83 metabolites and 7 hormones in response to glucose ingestion in 20 healthy human subjects. The findings highlight the differences between individuals and among molecules in the temporal patterns of blood molecules induced by oral glucose ingestion.

NPJ SYSTEMS BIOLOGY AND APPLICATIONS (2022)

添加到收藏夹

Review Biophysics

Advanced magnetic resonance spectroscopic neuroimaging: Experts' consensus recommendations

Andrew A. Maudsley et al.

Summary: MRSI has considerable potential in monitoring metabolic alterations, but its impact on clinical care remains limited. Despite advances in technology, further development is needed to bring advanced MRSI studies to clinical practice.

NMR IN BIOMEDICINE (2021)

添加到收藏夹

Article Radiology, Nuclear Medicine & Medical Imaging

Characterization and correction of center-frequency effects in X-nuclear eddy current compensations on a clinical MR system

Mary A. McLean et al.

Summary: The study found line-shape distortions characteristic of eddy currents for X-nuclei, not seen for H-1. Improvements in eddy current compensation for X-nuclei reduced these distortions and improved data quality for non-Cartesian imaging.

MAGNETIC RESONANCE IN MEDICINE (2021)

添加到收藏夹

Article Radiology, Nuclear Medicine & Medical Imaging

Comparison of hyperpolarized 13C and non-hyperpolarized deuterium MRI approaches for imaging cerebral glucose metabolism at 4.7 T

Cornelius von Morze et al.

Summary: This study directly compared two isotopic metabolic imaging approaches, HP C-13 MRI and DMI, for imaging different segments of cerebral glucose metabolism at 4.7 T. The results showed that while HP-C-13 MRI had better SNR and spatial resolution compared to DMI, the latter provided maps of lactate and Glx production, albeit with poorer spectral discrimination.

MAGNETIC RESONANCE IN MEDICINE (2021)

添加到收藏夹

Review Oncology

The use of hyperpolarised 13C-MRI in clinical body imaging to probe cancer metabolism

Ramona Woitek et al.

Summary: Metabolic reprogramming, particularly the Warburg effect, is a hallmark of cancer and can be utilized for clinical imaging through positron emission tomography (PET). A new emerging method, carbon-13 magnetic resonance imaging (MRI), with hyperpolarised [1-C-13]pyruvate injection, shows potential in noninvasive imaging of altered metabolism and has demonstrated safety and feasibility in translational studies. This technique offers unique information and applications in oncological body MRI, including disease characterisation, tumour heterogeneity mapping, and early response assessment.

BRITISH JOURNAL OF CANCER (2021)

添加到收藏夹

Article Neurosciences

Deuterium metabolic imaging in the human brain at 9.4 Tesla with high spatial and temporal resolution

Loreen Ruhm et al.

Summary: This study presents the first highly spatially resolved deuterium metabolic imaging (DMI) measurements of the human brain using a dedicated coil design and a fast chemical shift imaging (CSI) sequence at an ultrahigh field strength of 9.4 T. The H-2 metabolic measurements allowed for investigation of glucose metabolism in healthy subjects with a temporal resolution of 10 minutes. The results showed that the metabolism of deuterated glucose could be clearly visualized in high resolution metabolite images over the entire human brain, highlighting the benefits of ultrahigh field strength for X-nuclei MRSI like DMI.

NEUROIMAGE (2021)

添加到收藏夹

Article Radiology, Nuclear Medicine & Medical Imaging

Di-chromatic interpolation of magnetic resonance metabolic images

Nicholas Dwork et al.

Summary: This work presents an alternative method using higher-resolution proton images to provide additional spatial structure for interpolated metabolic images. Results are shown using hyperpolarized pyruvate, lactate, and bicarbonate images of the heart and brain from healthy human volunteers, a healthy porcine heart, and a human with prostate cancer.

MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE (2021)

添加到收藏夹

Article Biochemical Research Methods

Deuterium metabolic imaging - Back to the future

Henk M. De Feyter et al.

Summary: Deuterium metabolic spectroscopy and imaging are simple and robust MR-based methods for mapping metabolism with high temporal and/or spatial resolution. These methods offer advantages including high MR sensitivity, elimination of the need for water or lipid suppression, and relative immunity to magnetic field inhomogeneity. This makes them highly promising tools for both research and clinical imaging.

JOURNAL OF MAGNETIC RESONANCE (2021)

添加到收藏夹

Review Oncology

The Importance of Mitochondrial Pyruvate Carrier in Cancer Cell Metabolism and Tumorigenesis

Ainhoa Ruiz-Iglesias et al.

Summary: Cancer cells exhibit high glycolytic metabolism, with the regulation of the mitochondrial pyruvate carrier (MPC) being crucial in promoting tumor growth and affecting various aspects of tumorigenesis. Dysfunctional MPC can lead to increased glycolysis and aggressive tumor characteristics, while controversy exists regarding the role of MPC in cancer progression. Impaired MPC function can also result in acidification of the tumor microenvironment and support tumor growth through angiogenesis and immunosuppression.

CANCERS (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Comprehensive Literature Review of Hyperpolarized Carbon-13 MRI: The Road to Clinical Application

Michael Vaeggemose et al.

Summary: This review comprehensively assesses the development of hyperpolarized carbon-13 metabolic MRI, focusing on clinical applications. It reviews the status and challenges of translating HP carbon-13 into clinical use, along with the complexity, technical advancements, and future directions. The discussion emphasizes the limiting factor of the workflow for hyperpolarized carbon-13 MRI, highlighting recent successes in metabolic imaging.

METABOLITES (2021)

添加到收藏夹

Review Radiology, Nuclear Medicine & Medical Imaging

Current human brain applications and challenges of dynamic hyperpolarized carbon-13 labeled pyruvate MR metabolic imaging

Yan Li et al.

Summary: Hyperpolarized carbon-13 MR metabolic imaging is crucial for acquiring real-time dynamic metabolic information and gaining insights into metabolic pathways, but faces significant challenges in broader clinical translation despite rapid development.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2021)

添加到收藏夹

Article Oncology

Simultaneous Recording of the Uptake and Conversion of Glucose and Choline in Tumors by Deuterium Metabolic Imaging

Andor Veltien et al.

Summary: The study investigated the uptake and conversion of [H-2(9)]choline and [6,6'-H-2(2)]glucose in tumors using deuterium metabolic imaging. Results showed that the signals of these compounds could be observed separately in tumor H-2 spectra, with choline signal increasing initially and then decreasing or remaining stable, while glucose signal declined over time. This research suggests that simultaneous detection of choline and glucose in tumors has clinical potential for tumor characterization.

CANCERS (2021)

添加到收藏夹

Letter Radiology, Nuclear Medicine & Medical Imaging

Pilot Study Experiences With Hyperpolarized [1-13C]pyruvate MRI in Pancreatic Cancer Patients

Hans Stodkilde-Jorgensen et al.

JOURNAL OF MAGNETIC RESONANCE IMAGING (2020)

添加到收藏夹

Article Neurosciences

Lactate topography of the human brain using hyperpolarized 13C-MRI

Casey Y. Lee et al.

NEUROIMAGE (2020)

添加到收藏夹

Article Biophysics

On the magnetic field dependence of deuterium metabolic imaging

Robin A. de Graaf et al.

NMR IN BIOMEDICINE (2020)

添加到收藏夹

Article Radiology, Nuclear Medicine & Medical Imaging

Measuring Tumor Glycolytic Flux in Vivo by Using Fast Deuterium MRI

Felix Kreis et al.

RADIOLOGY (2020)

添加到收藏夹

Review Endocrinology & Metabolism

Hyperpolarized 13C MRI: A novel approach for probing cerebral metabolism in health and neurological disease

James T. Grist et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2020)

添加到收藏夹

Article Radiology, Nuclear Medicine & Medical Imaging

Super-Resolution Hyperpolarized 13C Imaging of Human Brain Using Patch-Based Algorithm

Junjie Ma et al.

TOMOGRAPHY (2020)

添加到收藏夹

Article Neuroimaging

Characterization of serial hyperpolarized 13C metabolic imaging in patients with glioma

Adam W. Autry et al.

NEUROIMAGE-CLINICAL (2020)

添加到收藏夹

Article Neurosciences

Quantifying normal human brain metabolism using hyperpolarized [1-13C] pyruvate and magnetic resonance imaging

James T. Grist et al.

NEUROIMAGE (2019)

添加到收藏夹

Article Multidisciplinary Sciences

White matter volume and white/gray matter ratio in mammalian species as a consequence of the universal scaling of cortical folding

Bruno Mota et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

添加到收藏夹

Article Neurosciences

Hyperpolarized [1-13C]lactate flux increased in the hippocampal region in diabetic mice

Young-Suk Choi et al.

MOLECULAR BRAIN (2019)

添加到收藏夹

Article Oncology

Metabolic Imaging of the Human Brain with Hyperpolarized 13C Pyruvate Demonstrates 13C Lactate Production in Brain Tumor Patients

Vesselin Z. Miloushev et al.

CANCER RESEARCH (2018)

添加到收藏夹

Article Multidisciplinary Sciences

13C Pyruvate Transport Across the Blood-Brain Barrier in Preclinical Hyperpolarised MRI

Jack J. Miller et al.

SCIENTIFIC REPORTS (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Deuterium metabolic imaging (DMI) for MRI-based 3D mapping of metabolism in vivo

Henk M. De Feyter et al.

SCIENCE ADVANCES (2018)

添加到收藏夹

Article Endocrinology & Metabolism

Quantitative assessment of brain glucose metabolic rates using in vivo deuterium magnetic resonance spectroscopy

Ming Lu et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Hyperpolarized 13C MR metabolic imaging can detect neuroinflammation in vivo in a multiple sclerosis murine model

Caroline Guglielmetti et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

添加到收藏夹

Article Multidisciplinary Sciences

OXSA: An open-source magnetic resonance spectroscopy analysis toolbox in MATLAB

Lucian A. B. Purvis et al.

PLOS ONE (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Metabolic imaging of energy metabolism in traumatic brain injury using hyperpolarized [1-13C] pyruvate

Stephen J. DeVience et al.

SCIENTIFIC REPORTS (2017)

添加到收藏夹

Article Radiology, Nuclear Medicine & Medical Imaging

Hyperpolarized 13C Magnetic Resonance Imaging Can Detect Metabolic Changes Characteristic of Penumbra in Ischemic Stroke

Yafang Xu et al.

TOMOGRAPHY (2017)

添加到收藏夹

Article Biophysics

A comparison of quantitative methods for clinical imaging with hyperpolarized 13C-pyruvate

Charlie J. Daniels et al.

NMR IN BIOMEDICINE (2016)

添加到收藏夹

Review Biochemistry & Molecular Biology

The Warburg Effect: How Does it Benefit Cancer Cells?

Maria V. Liberti et al.

TRENDS IN BIOCHEMICAL SCIENCES (2016)

添加到收藏夹

Article Physiology

Alzheimer's disease: the amyloid hypothesis and the Inverse Warburg effect

Lloyd A. Demetrius et al.

FRONTIERS IN PHYSIOLOGY (2015)

添加到收藏夹

Review Chemistry, Medicinal

Deuterated drugs: where are we now?

Graham S. Timmins

EXPERT OPINION ON THERAPEUTIC PATENTS (2014)

添加到收藏夹

Article Endocrinology & Metabolism

Imaging brain deoxyglucose uptake and metabolism by glucoCEST MRI

Fatima A. Nasrallah et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2013)

添加到收藏夹

Article Radiology, Nuclear Medicine & Medical Imaging

Combined parallel and partial fourier MR reconstruction for accelerated 8-channel hyperpolarized carbon-13 in vivo magnetic resonance Spectroscopic imaging (MRSI)

Michael A. Ohliger et al.

JOURNAL OF MAGNETIC RESONANCE IMAGING (2013)

添加到收藏夹

Article Radiology, Nuclear Medicine & Medical Imaging

Effects of Isoflurane Anesthesia on Hyperpolarized 13C Metabolic Measurements in Rat Brain

Sonal Josan et al.

MAGNETIC RESONANCE IN MEDICINE (2013)

添加到收藏夹

Article Biochemistry & Molecular Biology

In vivo imaging of glucose uptake and metabolism in tumors

Simon Walker-Samuel et al.

NATURE MEDICINE (2013)

添加到收藏夹

Article Neurosciences

Metabolic Communication between Astrocytes and Neurons via Bicarbonate-Responsive Soluble Adenylyl Cyclase

Hyun B. Choi et al.

NEURON (2012)

添加到收藏夹

Review Biophysics

MRS and MRSI guidance in molecular medicine: targeting and monitoring of choline and glucose metabolism in cancer

Kristine Glunde et al.

NMR IN BIOMEDICINE (2011)

添加到收藏夹

Article Biophysics

Transmit gain calibration for nonproton MR using the Bloch-Siegert shift

Rolf F. Schulte et al.

NMR IN BIOMEDICINE (2011)

添加到收藏夹

Article Biochemical Research Methods

Compressed sensing for resolution enhancement of hyperpolarized 13C flyback 3D-MRSI

Simon Hu et al.

JOURNAL OF MAGNETIC RESONANCE (2008)

添加到收藏夹

Article Endocrinology & Metabolism

Whole-body glycolysis measured by the deuterated-glucose disposal test correlates highly with insulin resistance in vivo

Carine Beysen et al.

DIABETES CARE (2007)

添加到收藏夹

Review Neurosciences

Activity-dependent regulation of energy metabolism by astrocytes: An update

Luc Pellerin et al.

GLIA (2007)

添加到收藏夹

Article Critical Care Medicine

Proton MR spectroscopy detected glutamate/glutamine is increased in children with traumatic brain injury

S Ashwal et al.

JOURNAL OF NEUROTRAUMA (2004)

添加到收藏夹

Article Endocrinology & Metabolism

Perspectives in diabetes - Neuronal glucosensing what do we know after 50 years?

BE Levin et al.

DIABETES (2004)

添加到收藏夹

Article Multidisciplinary Sciences

Increase in signal-to-noise ratio of >10,000 times in liquid-state NMR

JH Ardenkjaer-Larsen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

添加到收藏夹

Article Biochemistry & Molecular Biology

Immunogold cytochemistry identifies specialized membrane domains for monocarboxylate transport in the central nervous system

L Bergersen et al.

NEUROCHEMICAL RESEARCH (2002)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.