期刊
NEUROIMAGE
卷 254, 期 -, 页码 -出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2022.118958
关键词
Diffusion MRI; Human Connectome Project (HCP); axon diameter; brain; white matter; high b-value; human connectome scanner; peripheral nerve stimulation; radio frequency coil; sequence; preprocessing; fiber tracking; data sharing; tissue microstructure; clinical applications
资金
- NIH Blueprint for Neuroscience Research Grant [U01MH093765]
- NIH [U01-EB026996, P41-EB030006, K23-NS096056, R01-EB028797, U01EB025162, R03-EB031175, R01-EB020613, R01-MH116173, R01EB019437, R01-EB016695, R01-NS118187]
- NIH Office of the Director [DP5OD031854]
- National Natural Science Foundation of China [82071994]
- Shanghai Municipal Science and Technology Major Project [2018SHZDZX01]
- Shanghai Center for Brain Science and Brain-Inspired Technology
- Dutch Research Council (NWO) [17331]
- Sir Henry Wellcome Fellowship [215944/Z/19/Z]
- German Research Foundation, DFG [SPP 2041]
- Wellcome Trust Investigator Award [219536/Z/19/Z]
- European Research Council under the European Union's Seventh Framework Programme (FP7/2007-2013)/ERC grant [616905]
- NISCI project - European Union's Horizon 2020 research and innovation program [681094]
- BMBF [01EW1711A, 01EW1711B]
- Advanced Research Projects Agency-Energy (ARPA-E) [DE-AR0001063]
- ZJ Lab
- Wellcome Trust [219536/Z/19/Z] Funding Source: Wellcome Trust
In the past decade, tremendous efforts have been made to advance cutting-edge MRI technology in order to map the structural connectivity in the living human brain. This review article summarizes the technical developments in using the Connectom scanner for large-scale and scientific studies of the human brain, and discusses the scientific impact of the Connectom MRI scanner.
Tremendous efforts have been made in the last decade to advance cutting-edge MRI technology in pursuit of mapping structural connectivity in the living human brain with unprecedented sensitivity and speed. The first Connectom 3T MRI scanner equipped with a 300 mT/m whole-body gradient system was installed at the Mas-sachusetts General Hospital in 2011 and was specifically constructed as part of the Human Connectome Project. Since that time, numerous technological advances have been made to enable the broader use of the Connectom high gradient system for diffusion tractography and tissue microstructure studies and leverage its unique advan-tages and sensitivity to resolving macroscopic and microscopic structural information in neural tissue for clinical and neuroscientific studies. The goal of this review article is to summarize the technical developments that have emerged in the last decade to support and promote large-scale and scientific studies of the human brain using the Connectom scanner. We provide a brief historical perspective on the development of Connectom gradient tech-nology and the efforts that led to the installation of three other Connectom 3T MRI scanners worldwide - one in the United Kingdom in Cardiff, Wales, another in continental Europe in Leipzig, Germany, and the latest in Asia in Shanghai, China. We summarize the key developments in gradient hardware and image acquisition technology that have formed the backbone of Connectom-related research efforts, including the rich array of high-sensitivity receiver coils, pulse sequences, image artifact correction strategies and data preprocessing methods needed to optimize the quality of high-gradient strength diffusion MRI data for subsequent analyses. Finally, we review the scientific impact of the Connectom MRI scanner, including advances in diffusion tractography, tissue microstructural imaging, ex vivo validation, and clinical investigations that have been enabled by Connectom technology. We conclude with brief insights into the unique value of strong gradients for diffusion MRI and where the field is headed in the coming years.
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