期刊
NEUROIMAGE
卷 255, 期 -, 页码 -出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2022.119185
关键词
Vicarious traumatization; Connectome-based predictive modeling; Posttraumatic stress disorder; Depression; Anxiety; Psychoradiology
资金
- National Natural Science Foundation of China [82001800, 81621003, 81820108018, 82027808]
- China Postdoctoral Science Foundation [2020M683317]
- Post-Doctor Research Project, West China Hospital, Sichuan University [2019HXBH104, 2020HXBH092]
This study aims to explore the relationship between vicarious traumatization and general distress during the COVID-19 pandemic and identify the brain functional connectivity associated with vicarious traumatization. The results showed that the negative network model could predict individuals' scores of vicarious traumatization, with functional connectivity primarily distributed in different brain networks. Furthermore, the study found that vicarious traumatization mediated the influence of brain functional connectivity on general distress. These findings are important for understanding and predicting individuals' psychological distress.
As characterized by repeated exposure of others' trauma, vicarious traumatization is a common negative psychological reaction during the COVID-19 pandemic and plays a crucial role in the development of general mental distress. This study aims to identify functional connectome that encodes individual variations of pandemic-related vicarious traumatization and reveal the underlying brain-vicarious traumatization mechanism in predicting general distress. The eligible subjects were 105 general university students (60 females, aged from 19 to 27 years) undergoing brain MRI scanning and baseline behavioral tests (October 2019 to January 2020), whom were re-contacted for COVID-related vicarious traumatization measurement (February to April 2020) and follow-up general distress evaluation (March to April 2021). We applied a connectome-based predictive modeling (CPM) approach to identify the functional connectome supporting vicarious traumatization based on a 268-region-parcellation assigned to network memberships. The CPM analyses showed that only the negative network model stably predicted individuals' vicarious traumatization scores (q 2 =-0.18, MSE = 617, r [predicted, actual] = 0.18, p = 0.024), with the contributing functional connectivity primarily distributed in the fronto-parietal, default mode, medial frontal, salience, and motor network. Furthermore, mediation analysis revealed that vicarious traumatization mediated the influence of brain functional connectome on general distress. Importantly, our results were independent of baseline family socioeconomic status, other stressful life events and general mental health as well as age, sex and head motion. Our study is the first to provide evidence for the functional neural markers of vicarious traumatization and reveal an underlying neuropsychological pathway to predict distress symptoms in which brain functional connectome affects general distress via vicarious traumatization.
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