Effect of intracolonic volume on gastric sensory-motor responses in constipation-predominant irritable bowel syndrome

Background Interaction between gut stimuli may induce symptom overlap in patients with functional gastrointestinal disorders. The aim is to determine the effect of increased volumes of colonic contents on gastric sensory/motor responses and satiety in patients with constipation-predominant irritable bowel syndrome (IBS-C) and overlapping dyspeptic symptoms, and a cohort of healthy subjects. Methods In 15 patients with IBS-C and 10 healthy subjects, the effect of real versus sham colonic filling with gas (1080 ml) on gastric sensitivity (measured by stepwise distensions of the stomach), gastric compliance, abdominal perception, and nutrient drink tolerance was studied on separate days. Results In healthy subjects, colonic gas filling induced an increment in gastric sensitivity to distension (mean score 2.0 +/- 0.2 before, and 3.0 +/- 0.4 after; p = 0.038). In IBS, basal sensitivity was greater and remained unchanged after colonic gas filling (score 4.0 +/- 0.1 and 3.8 +/- 0.3, respectively; p < 0.001 vs. basal in health). Colonic gas infusion induced abdominal symptoms that were significantly greater in IBS-C (score 2.6 +/- 0.1) than in health (score 1.7 +/- 0.4; p = 0.027), with minor changes in gastric tone, and no changes in gastric compliance in both groups. Colonic filling produced a profound reduction in nutrient drink tolerance in IBS (791 +/- 87 ml sham filling, 491 +/- 58 ml gas filling; p < 0.001) but only a minor reduction in health (940 +/- 70 ml sham filling, 860 +/- 94 ml gas filling; p = 0.223). Conclusions & Inferences The volume of the colonic contents modulates satiety in patients with IBS-C, due to a general visceral pan-hypersensitivity. These effects should be considered in the choice of treatment for constipation in these patients.

Automated summary

The volume of colonic contents modulates satiety in patients with constipation-predominant irritable bowel syndrome (IBS-C) due to general visceral pan-hypersensitivity.