4.5 Article

Relationship between cerebrospinal fluid neurodegeneration biomarkers and temporal brain atrophy in cognitively healthy older adults

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Neurosciences

The probabilistic model of Alzheimer disease: the amyloid hypothesis revised

Giovanni B. Frisoni et al.

Summary: The amyloid hypothesis has long been the leading model for the pathogenesis of Alzheimer's disease, but a probabilistic model is proposed as an alternative due to the increasing understanding of the complex biology of Alzheimer's disease. This new model suggests that genetic factors, environmental exposures, and lower-risk genes play significant roles in different types of Alzheimer's disease, leading to a better understanding of disease pathophysiology and potentially accelerating the development of prevention and treatment strategies.

NATURE REVIEWS NEUROSCIENCE (2022)

Article Clinical Neurology

Untangling the association of amyloid-beta and tau with synaptic and axonal loss in Alzheimer's disease

Joana B. Pereira et al.

Summary: The study found that in early Alzheimer's disease, presynaptic and postsynaptic markers are elevated and associated with more severe amyloid-beta pathology, memory decline, and changes in the default mode network. In later disease stages, abnormal levels of neurofilament light chain were observed, correlated with more tau pathology and worse global cognition.
Article Clinical Neurology

Neurofilament light chain predicts future dementia risk in cerebral small vessel disease

Marco Egle et al.

Summary: Baseline levels of NfL predict cognitive decline and risk of converting to dementia, but there were no detectable changes in NfL values over the follow-up period.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2021)

Article Neurosciences

A recipe for accurate estimation of lifespan brain trajectories, distinguishing longitudinal and cohort effects

Oystein Sorensen et al.

Summary: This paper addresses the estimation of how different parts of the brain develop and change throughout the lifespan, proposing the use of Generalized Additive Mixed Models (GAMMs) as an alternative method. The research shows that GAMMs are able to more accurately fit lifespan trajectories, distinguish longitudinal and cross-sectional effects, and estimate the effects of genetic and environmental exposures.

NEUROIMAGE (2021)

Article Biology

Individual variations in 'brain age' relate to early-life factors more than to longitudinal brain change

Didac Vidal-Pineiro et al.

Summary: The measurement of brain age does not accurately reflect the aging process of the brain, but rather pre-existing brain conditions. Genetics and early brain development play a significant role in brain health. Future studies should focus on utilizing serial measurements to track changes in the brain over time.
Article Biology

Standardizing workflows in imaging transcriptomics with the abagen toolbox

Ross D. Markello et al.

Summary: The study developed the abagen toolbox for analyzing transcriptomic data and found that the choice of processing pipeline significantly influences research outcomes when using the Allen Human Brain Atlas. The results show that processing steps affecting gene normalization have the greatest impact on downstream statistical inferences and conclusions.
Article Clinical Neurology

To what degree is late life cognitive decline driven by age-related neuropathologies?

Patricia A. Boyle et al.

Summary: The study found that cognitive decline in old age is driven by a wide array of neuropathologies, with Alzheimer's disease, infarcts, non-Alzheimer's disease neurodegenerative diseases, and cerebrovascular conditions playing significant roles. While most pathological indices were associated with faster decline, they only accounted for a portion of the variation in decline, highlighting the complexity of cognitive ageing.
Review Biochemistry & Molecular Biology

Biomarkers for neurodegenerative diseases

Oskar Hansson

Summary: Biomarkers for neurodegenerative diseases play a crucial role in improving diagnostic workup and therapy monitoring, with emerging blood-based markers and discussions on their implementation in clinical practice and trials.

NATURE MEDICINE (2021)

Article Multidisciplinary Sciences

Serum neurofilament light levels in normal aging and their association with morphologic brain changes

Michael Khalil et al.

NATURE COMMUNICATIONS (2020)

Article Neurosciences

Generative modeling of brain maps with spatial autocorrelation

Joshua B. Burt et al.

NEUROIMAGE (2020)

Article Clinical Neurology

NFL is a marker of treatment response in children with SMA treated with nusinersen

Bob Olsson et al.

JOURNAL OF NEUROLOGY (2019)

Review Neurosciences

Neuroimaging Biomarkers for Alzheimer's Disease

Freddie Marquez et al.

MOLECULAR NEURODEGENERATION (2019)

Editorial Material Psychology, Biological

Harnessing reliability for neuroscience research

Xi-Nian Zuo et al.

NATURE HUMAN BEHAVIOUR (2019)

Article Clinical Neurology

Comparison of variables associated with cerebrospinal fluid neurofilament, total-tau, and neurogranin

Michelle M. Mielke et al.

ALZHEIMERS & DEMENTIA (2019)

Review Biochemistry & Molecular Biology

Cerebrospinal fluid biomarkers for understanding multiple aspects of Alzheimer's disease pathogenesis

Kunal Dhiman et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2019)

Review Clinical Neurology

NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease

Clifford R. Jack et al.

ALZHEIMERS & DEMENTIA (2018)

Article Clinical Neurology

Person-Specific Contribution of Neuropathologies to Cognitive Loss in Old Age

Patricia A. Boyle et al.

ANNALS OF NEUROLOGY (2018)

Review Neurosciences

From Cerebrospinal Fluid to Blood: The Third Wave of Fluid Biomarkers for Alzheimer's Disease

Henrik Zetterberg et al.

JOURNAL OF ALZHEIMERS DISEASE (2018)

Review Clinical Neurology

Neurofilaments as biomarkers in neurological disorders

Michael Khalil et al.

NATURE REVIEWS NEUROLOGY (2018)

Article Clinical Neurology

Non-beta-amyloid/tau cerebrospinal fluid markers inform staging and progression in Alzheimer's disease

Umesh Gangishetti et al.

ALZHEIMERS RESEARCH & THERAPY (2018)

Article Geriatrics & Gerontology

CSF neurofilament light levels predict hippocampal atrophy in cognitively healthy older adults

Ane-Victoria Idland et al.

NEUROBIOLOGY OF AGING (2017)

Article Geriatrics & Gerontology

Longitudinal association between hippocampus atrophy and episodic-memory decline

Tetiana Gorbach et al.

NEUROBIOLOGY OF AGING (2017)

Article Clinical Neurology

Serum neurofilament light is sensitive to active cerebral small vessel disease

Thomas Gattringer et al.

NEUROLOGY (2017)

Review Multidisciplinary Sciences

Ageing, neurodegeneration and brain rejuvenation

Tony Wyss-Coray

NATURE (2016)

Article Multidisciplinary Sciences

Early role of vascular dysregulation on late-onset Alzheimer's disease based on multifactorial data-driven analysis

Y. Iturria-Medina et al.

NATURE COMMUNICATIONS (2016)

Editorial Material Clinical Neurology

Cerebrospinal Biomarkers in Alzheimer Disease-Potential Roles as Markers of Prognosis and Neuroplasticity

Steven T. DeKosky et al.

JAMA NEUROLOGY (2016)

Review Cell Biology

Review on intermediate filaments of the nervous system and their pathological alterations

Claire Lepinoux-Chambaud et al.

HISTOCHEMISTRY AND CELL BIOLOGY (2013)

Article Neurosciences

Biomarkers of Alzheimer's Disease Among Mexican Americans

Sid E. O'Bryant et al.

JOURNAL OF ALZHEIMERS DISEASE (2013)

Article Neurosciences

Heart fatty acid binding protein and Aβ-associated Alzheimer's neurodegeneration

Rahul S. Desikan et al.

MOLECULAR NEURODEGENERATION (2013)

Article Multidisciplinary Sciences

An anatomically comprehensive atlas of the adult human brain transcriptome

Michael J. Hawrylycz et al.

NATURE (2012)

Review Physiology

The multiple roles of fatty acid handling proteins in brain

Valentine S. F. Moulle et al.

FRONTIERS IN PHYSIOLOGY (2012)

Article Clinical Neurology

Qualification of the analytical and clinical performance of CSF biomarker analyses in ADNI

Leslie M. Shaw et al.

ACTA NEUROPATHOLOGICA (2011)

Review Geriatrics & Gerontology

Total and phosphorylated tau protein as biological markers of Alzheimer's disease

Harald Hampel et al.

EXPERIMENTAL GERONTOLOGY (2010)

Review Biochemistry & Molecular Biology

Neurogranin, a Link Between Calcium/Calmodulin and Protein Kinase C Signaling in Synaptic Plasticity

F. Javier Diez-Guerra

IUBMB LIFE (2010)

Article Clinical Neurology

Cerebrospinal Fluid Biomarker Signature in Alzheimer's Disease Neuroimaging Initiative Subjects

Leslie M. Shaw et al.

ANNALS OF NEUROLOGY (2009)

Article Geriatrics & Gerontology

Missing Data: A Special Challenge in Aging Research

Susan E. Hardy et al.

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY (2009)

Article Neurosciences

The Alzheimer's disease neuroimaging initiative

SG Mueller et al.

NEUROIMAGING CLINICS OF NORTH AMERICA (2005)

Article Multidisciplinary Sciences

Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

A Subramanian et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Clinical Neurology

Neurofilament phosphoforms: Surrogate markers for axonal injury, degeneration and loss

A Petzold

JOURNAL OF THE NEUROLOGICAL SCIENCES (2005)

Article Nutrition & Dietetics

Control of gene expression by fatty acids

JP Pégorier et al.

JOURNAL OF NUTRITION (2004)

Article Medical Laboratory Technology

Brain- and heart-type fatty acid-binding proteins in the brain: Tissue distribution and clinical utility

MMAL Pelsers et al.

CLINICAL CHEMISTRY (2004)

Article Neurosciences

The effects of age on the cells in layer 1 of primate cerebral cortex

A Peters et al.

CEREBRAL CORTEX (2002)

Article Multidisciplinary Sciences

Involvement of neurogranin in the modulation of calcium/calmodulin-dependent protein kinase II, synaptic plasticity, and spatial learning: A study with knockout mice

JH Pak et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)