期刊
NEUROBIOLOGY OF AGING
卷 116, 期 -, 页码 80-91出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2022.04.010
关键词
Cognitively healthy older adults; Neurodegeneration biomarkers; FABP3; Neurogranin; NFL; CSF
资金
- Department of Psychology, University of Oslo
- Norwegian Research Council
- European Research Council
- South-Eastern Norway Regional Health Authorities
- Norwegian Health Association
- Swedish Research Council
- Swedish State Support for Clinical Research
- Alzheimer Drug Discovery Foundation (ADDF) , USA
- AD Strategic Fund
- Alzheimer's Association
- Olav Thon Foundation
- Erling-Persson Family Foundation
- Stiftelsen fur Gamla Tjnarinnor, Hjarnfonden, Sweden
- European Union
- UK Dementia Research Institute at UCL
- Swedish Alzheimer Foundation
- Hjarnfonden, Sweden
- Swedish state
- ALF-agreement
- European Union Joint Program for Neurodegenerative Disorders
- National Institute of Health (NIH) , USA
- ADNI (NIH)
- DOD ADNI (Department of Defense)
- National Institute on Aging, National Institute of Biomedical Imaging and Bioengineering
- Canadian Institutes of Health Research
- [ES694407]
- [283634]
- [725025]
- [313440]
- [681712]
- [2017095]
- [2018-02532]
- [2017-00915]
- [ALFGBG-720931]
- [201809-2016862]
- [RDAPB-201809-2016615]
- [ADSF-21-831376-C]
- [ADSF-21-831381-C]
- [ADSF-21-831377-C]
- [ZEN-21-84 84 95]
- [FO2019-0228]
- [860197]
- [AF-742881]
- [FO2017-0243]
- [ALFGBG-715986]
- [JPND2019-466-236]
- [1R01AG068398-01]
- [U01 AG024904]
- [W81XWH-12-2-0012]
This study investigates whether cerebrospinal fluid biomarkers of neurodegeneration can predict brain atrophy in cognitively healthy older adults and identifies the neural substrates underlying these associations. The results show that specific CSF biomarkers are useful for predicting specific features of brain atrophy, independently of amyloid and tau pathology biomarkers.
It is unclear whether cerebrospinal fluid (CSF) biomarkers of neurodegeneration predict brain atrophy in cognitively healthy older adults, whether these associations can be explained by phosphorylated tau181 (p-tau) and the 42 amino acid form of amyloid-beta (A beta 42) biomarkers, and which neural substrates may drive these associations. We addressed these questions in 2 samples of cognitively healthy older adults who underwent longitudinal structural MRI up to 7 years and had baseline CSF levels of heart-type fatty-acid binding protein (FABP3) = , total-tau, neurogranin, and neurofilament light (NFL) (n = 189, scans = 721). The results showed that NFL, total-tau, and FABP3 predicted entorhinal thinning and hippocampal atrophy. Brain atrophy was not moderated by A beta 42 and the associations between NFL and FABP3 with brain atrophy were independent of p-tau. The spatial pattern of cortical atrophy associated with the biomarkers overlapped with neurogenetic profiles associated with expression in the axonal (total-tau, NFL) and dendritic (neurogranin) components. CSF biomarkers of neurodegeneration are useful for predicting specific features of brain atrophy in older adults, independently of amyloid and tau pathology biomarkers. (C) 2022 The Author(s). Published by Elsevier Inc.
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