期刊
NEPHROLOGY DIALYSIS TRANSPLANTATION
卷 37, 期 12, 页码 2351-2362出版社
OXFORD UNIV PRESS
DOI: 10.1093/ndt/gfac207
关键词
chronic renal failure; chronic renal insufficiency; guidelines; pediatrics; ultrasonography
资金
- European Reference Network for Rare Kidney Disorders - European Union
- German Research Foundation (DFG) [454024652, 445703531]
- European Research Council (ERC) [101001791]
- Federal Ministry of Education and Research [STOP-FSGS-01GM1901A]
- Koeln Fortune program
- Gusyk program, Faculty of Medicine, University of Cologne
- German Federal Ministry of Research and Education (BMBF) [01GM1515, 01GM1903]
- Medical Research Council [MR/T016809/1]
Kidney dysplasia is a common cause of chronic kidney failure in children, but the lack of clear clinical parameters leads to imprecise communication among healthcare professionals and patients. Suggestions based on structured literature search have been made to improve disease understanding and treatment.
Kidney dysplasia is one of the most frequent causes of chronic kidney failure in children. While dysplasia is a histological diagnosis, the term 'kidney dysplasia' is frequently used in daily clinical life without histopathological confirmation. Clinical parameters of kidney dysplasia have not been clearly defined, leading to imprecise communication amongst healthcare professionals and patients. This lack of consensus hampers precise disease understanding and the development of specific therapies. Based on a structured literature search, we here suggest a common basis for clinical, imaging, genetic, pathological and basic science aspects of non-obstructive kidney dysplasia associated with functional kidney impairment. We propose to accept hallmark sonographic findings as surrogate parameters defining a clinical diagnosis of dysplastic kidneys. We suggest differentiated clinical follow-up plans for children with kidney dysplasia and summarize established monogenic causes for non-obstructive kidney dysplasia. Finally, we point out and discuss research gaps in the field.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据