4.5 Review

Assessment of disease outcome measures in systemic sclerosis

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Summary: This study aims to estimate the effect of disease activity as measured by different indices on the risk of subsequent organ damage in systemic sclerosis. The results indicate that certain indices correlate with organ involvement and can predict changes in key indicators.

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Safety and Efficacy of B-Cell Depletion with Rituximab for the Treatment of Systemic Sclerosis-associated Pulmonary Arterial Hypertension A Multicenter, Double-Blind, Randomized, Placebo-controlled Trial

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Summary: The study suggested that B-cell depletion therapy may have potential efficacy and safety for SSc-PAH. Low levels of RF, IL-12, and IL-17 may serve as promising predictors of rituximab response. Despite initially showing no significant difference in the primary analysis, the rituximab group demonstrated a statistically significant improvement in 6MWD at Week 24 when considering data through Week 48.

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Clinical Relevance of the Serial Measurement of Krebs von den Lungen-6 Levels in Patients with Systemic Sclerosis-Associated Interstitial Lung Disease

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Tracy Tabib et al.

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Julien Guiot et al.

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