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GENES & DEVELOPMENT (2016)
Higher expression of XPF is a critical factor in intrinsic chemotherapy resistance of human renal cell carcinoma
Qiao Zhang et al.
INTERNATIONAL JOURNAL OF CANCER (2016)
HBP1-mediated Regulation of p21 Protein through the Mdm2/p53 and TCF4/EZH2 Pathways and Its Impact on Cell Senescence and Tumorigenesis
Yifan Chen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2016)
Challenges and opportunities for stem cell therapy in patients with chronic kidney disease
LaTonya J. Hickson et al.
KIDNEY INTERNATIONAL (2016)
ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age-Related Diseases
Pierpaola Davalli et al.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2016)
Knockdown of SIRT6 Enables Human Bone Marrow Mesenchymal Stem Cell Senescence
Xiao-Yan Zhai et al.
REJUVENATION RESEARCH (2016)
Restoration of Mitochondrial NAD+ Levels Delays Stem Cell Senescence and Facilitates Reprogramming of Aged Somatic Cells
Myung Jin Son et al.
STEM CELLS (2016)
Autophagy and Immune Senescence
Hanlin Zhang et al.
TRENDS IN MOLECULAR MEDICINE (2016)
Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis
Megan K. Ruhland et al.
NATURE COMMUNICATIONS (2016)
ATF6α regulates morphological changes associated with senescence in human fibroblasts
Clementine Druelle et al.
ONCOTARGET (2016)
Impact of ER stress-regulated ATF4/p16 signaling on the premature senescence of renal tubular epithelial cells in diabetic nephropathy
Jun Liu et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2015)
Suppression of Autophagy Dysregulates the Antioxidant Response and Causes Premature Senescence of Melanocytes
Cheng-Feng Zhang et al.
JOURNAL OF INVESTIGATIVE DERMATOLOGY (2015)
Telomerase deficiency delays renal recovery in mice after ischemia-reperfusion injury by impairing autophagy
Huifang Cheng et al.
KIDNEY INTERNATIONAL (2015)
Hyperphosphatemia induces cellular senescence in human aorta smooth muscle cells through integrin linked kinase (ILK) up-regulation
Nuria Troyano et al.
MECHANISMS OF AGEING AND DEVELOPMENT (2015)
Multiple facets of histone variant H2AX: a DNA double-strand-break marker with several biological functions
Valentina Turinetto et al.
NUCLEIC ACIDS RESEARCH (2015)
Glucose Oxidase Induces Cellular Senescence in Immortal Renal Cells through ILK by Downregulating Klotho Gene Expression
Nuria Troyano-Suarez et al.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2015)
JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age
Ming Xu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
c-Maf regulates pluripotency genes, proliferation/self-renewal, and lineage commitment in ROS-mediated senescence of human mesenchymal stem cells
Pei-Min Chen et al.
ONCOTARGET (2015)
Bone Marrow Mesenchymal Stem Cell Transplantation Retards the Natural Senescence of Rat Hearts
Mingyu Zhang et al.
STEM CELLS TRANSLATIONAL MEDICINE (2015)
High Glucose Induces Bone Marrow-Derived Mesenchymal Stem Cell Senescence by Upregulating Autophagy
Tzu-Ching Chang et al.
PLOS ONE (2015)
Metformin and Resveratrol Inhibited High Glucose-Induced Metabolic Memory of Endothelial Senescence through SIRT1/p300/p53/p21 Pathway
Erli Zhang et al.
PLOS ONE (2015)
Glucocorticoids induce senescence in primary human tenocytes by inhibition of sirtuin 1 and activation of the p53/p21 pathway: in vivo and in vitro evidence
Raewyn C. Poulsen et al.
ANNALS OF THE RHEUMATIC DISEASES (2014)
Rat Induced Pluripotent Stem Cells Protect H9C2 Cells from Cellular Senescence via a Paracrine Mechanism
Yuzhen Zhang et al.
CARDIOLOGY (2014)
Chromatin maintenance and dynamics in senescence: a spotlight on SAHF formation and the epigenome of senescent cells
Armelle Corpet et al.
CHROMOSOMA (2014)
Irreparable telomeric DNA damage and persistent DDR signalling as a shared causative mechanism of cellular senescence and ageing
Francesca Rossiello et al.
CURRENT OPINION IN GENETICS & DEVELOPMENT (2014)
An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA
Marco Demaria et al.
DEVELOPMENTAL CELL (2014)
Evidence for Less Marked Potential Signs of T-Cell Immunosenescence in Centenarian Offspring Than in the General Age-Matched Population
Mariavaleria Pellicano et al.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2014)
In Vivo and In Vitro Analysis of Age-Associated Changes and Somatic Cellular Senescence in Renal Epithelial Cells
Birgit Berkenkamp et al.
PLOS ONE (2014)
p38MAPK Plays a Crucial Role in Stromal-Mediated Tumorigenesis
Elise Alspach et al.
CANCER DISCOVERY (2014)
Repression of PLA2R1 by c-MYC and HIF-2alpha promotes cancer growth
David Vindrieux et al.
ONCOTARGET (2014)
Stem cell senescence. Effects of REAC technology on telomerase-independent and telomerase-dependent pathways
S. Rinaldi et al.
SCIENTIFIC REPORTS (2014)
CDK4/6 inhibition induces epithelial cell cycle arrest and ameliorates acute kidney injury
Derek P. DiRocco et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2014)
MiR-146a as marker of senescence-associated pro-inflammatory status in cells involved in vascular remodelling
Fabiola Olivieri et al.
AGE (2013)
In senescence, age-associated B cells secrete TNF and inhibit survival of B-cell precursors*
Michelle Ratliff et al.
AGING CELL (2013)
Metformin inhibits the senescence-associated secretory phenotype by interfering with IKK/NF-B activation
Olga Moiseeva et al.
AGING CELL (2013)
Caveolin-1/PTRF upregulation constitutes a mechanism for mediating p53-induced cellular senescence: implications for evidence-based therapy of delayed wound healing in diabetes
Milad S. Bitar et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2013)
Programmed Cell Senescence during Mammalian Embryonic Development
Daniel Munoz-Espin et al.
CELL (2013)
Senescence Is a Developmental Mechanism that Contributes to Embryonic Growth and Patterning
Mekayla Storer et al.
CELL (2013)
Redox Control of the Senescence Regulator Interleukin-1α and the Secretory Phenotype
Donald A. McCarthy et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
p53-dependent chemokine production by senescent tumor cells supports NKG2D-dependent tumor elimination by natural killer cells
Alexandre Iannello et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2013)
Loss of Klotho Contributes to Kidney Injury by Derepression of Wnt/β-Catenin Signaling
Lili Zhou et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2013)
Carcinogen-specific mutational and epigenetic alterations in INK4A, INK4B and p53 tumour-suppressor genes drive induced senescence bypass in normal diploid mammalian cells
H. Yasaei et al.
ONCOGENE (2013)
Sarcopenia, obesity, and natural killer cell immune senescence in aging: Altered cytokine levels as a common mechanism
Charles T. Lutz et al.
AGING-US (2012)
Senescence as A Consequence of Ginsenoside Rg1 Response on K562 Human Leukemia Cell Line
Jun Liu et al.
ASIAN PACIFIC JOURNAL OF CANCER PREVENTION (2012)
Chromatin Remodeling Underlies the Senescence-Associated Secretory Phenotype of Tumor Stromal Fibroblasts That Supports Cancer Progression
Ermira Pazolli et al.
CANCER RESEARCH (2012)
Depletion of CSN5 inhibits Ras-mediated tumorigenesis by inducing premature senescence in p53-null cells
Ikuko Tsujimoto et al.
FEBS LETTERS (2012)
Age-dependent increases in the oxidative damage of DNA, RNA, and their metabolites in normal and senescence-accelerated mice analyzed by LC-MS/MS: Urinary 8-oxoguanosine as a novel biomarker of aging
Wei Gan et al.
FREE RADICAL BIOLOGY AND MEDICINE (2012)
Lamin B1 loss is a senescence-associated biomarker
Adam Freund et al.
MOLECULAR BIOLOGY OF THE CELL (2012)
Inactivation of Heat Shock Factor Hsf4 Induces Cellular Senescence and Suppresses Tumorigenesis In Vivo
Xiongjie Jin et al.
MOLECULAR CANCER RESEARCH (2012)
Onset of Immune Senescence Defined by Unbiased Pyrosequencing of Human Immunoglobulin mRNA Repertoires
Florian Rubelt et al.
PLOS ONE (2012)
Accelerated senescence of renal tubular epithelial cells is associated with disease progression of patients with immunoglobulin A (IgA) nephropathy
Jun Liu et al.
TRANSLATIONAL RESEARCH (2012)
Differences in the expression of five senescence markers in oral cancer, oral leukoplakia and control samples in humans
Antonio Bascones-Martinez et al.
ONCOLOGY LETTERS (2012)
Oxydative stress alters nuclear shape through lamins dysregulation A route to senescence
Aurelia Barascu et al.
NUCLEUS (2012)
The splicing factor SRSF1 as a marker for endothelial senescence
Francisco Javier Blanco et al.
FRONTIERS IN PHYSIOLOGY (2012)
INK4a deletion results in improved kidney regeneration and decreased capillary rarefaction after ischemia-reperfusion injury
David H. Lee et al.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2012)
Accelerated immune senescence and reduced response to vaccination in ovariectomized female rhesus macaques
Flora Engelmann et al.
AGE (2011)
NKG2D expression in CD4+T lymphocytes as a marker of senescence in the aged immune system
Rebeca Alonso-Arias et al.
AGE (2011)
Metformin and the ATM DNA damage response (DDR): Accelerating the onset of stress-induced senescence to boost protection against cancer
Javier A. Menendez et al.
AGING-US (2011)
Ewing sarcoma gene Ews regulates hematopoietic stem cell senescence
Joonseok Cho et al.
BLOOD (2011)
Mdm2-p53 signaling regulates epidermal stem cell senescence and premature aging phenotypes in mouse skin
Hugh S. Gannon et al.
DEVELOPMENTAL BIOLOGY (2011)
Loss of Bcl-2 During the Senescence Exacerbates the Impaired Angiogenic Functions in Endothelial Cells by Deteriorating the Mitochondrial Redox State
Maki Uraoka et al.
HYPERTENSION (2011)
Senescence surveillance of pre-malignant hepatocytes limits liver cancer development
Tae-Won Kang et al.
NATURE (2011)
Reduced EBF expression underlies loss of B-cell potential of hematopoietic progenitors with age
Chloe Lescale et al.
AGING CELL (2010)
Sustained CD28 Expression Delays Multiple Features of Replicative Senescence in Human CD8 T Lymphocytes
Stanley T. Parish et al.
JOURNAL OF CLINICAL IMMUNOLOGY (2010)
A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis
Andrea Alimonti et al.
JOURNAL OF CLINICAL INVESTIGATION (2010)
Telomere Shortening Reduces Regenerative Capacity after Acute Kidney Injury
Jens H. Westhoff et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2010)
The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing
Joon-Il Jun et al.
NATURE CELL BIOLOGY (2010)
Immunosenescence increases the rate of acceptance of kidney allotransplants in elderly recipients through exhaustion of CD4+ T-cells
Piotr Trzonkowski et al.
MECHANISMS OF AGEING AND DEVELOPMENT (2010)
KLRG1-more than a marker for T cell senescence
Sian M. Henson et al.
AGE (2009)
Inhibition of thioredoxin reductase 1 by caveolin 1 promotes stress-induced premature senescence
Daniela Volonte et al.
EMBO REPORTS (2009)
TAp63 induces senescence and suppresses tumorigenesis in vivo
Xuecui Guo et al.
NATURE CELL BIOLOGY (2009)
Protocols to detect senescence-associated beta-galactosidase (SA-beta gal) activity, a biomarker of senescent cells in culture and in vivo
Florence Debacq-Chainiaux et al.
NATURE PROTOCOLS (2009)
Accelerated senescence: An emerging role in tumor cell response to chemotherapy and radiation
David A. Gewirtz et al.
BIOCHEMICAL PHARMACOLOGY (2008)
S-Phase-specific activation of PKCα induces senescence in non-small cell lung cancer cells
Jose L. Oliva et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
The oxidative stress adaptor p66Shc is required for permanent embryo arrest in vitro
Laura A. Favetta et al.
BMC DEVELOPMENTAL BIOLOGY (2007)
Occludin-mediated premature senescence is a fail-safe mechanism against tumorigenesis in breast carcinoma cells
Makoto Osanai et al.
CANCER SCIENCE (2007)
Dose-dependent oncogene-induced senescence in vivo and its evasion during mammary tumorigenesis
Christopher J. Sarkisian et al.
NATURE CELL BIOLOGY (2007)
Senescent human fibroblasts increase the early growth of xenograft tumors via matrix metalloproteinase secretion
Dan Liu et al.
CANCER RESEARCH (2007)
Estrogens decrease γ-ray-induced senescence and maintain cell cycle progression in breast cancer cells independently of p53
Robert-Alain Toillon et al.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2007)
Accelerated expression of senescence associated cell cycle inhibitor p16INK4A in kidneys with glomerular disease
B. Sis et al.
KIDNEY INTERNATIONAL (2007)
Chronic melatonin treatment prevents age-dependent cardiac mitochondrial dysfunction in senescence-accelerated mice
Maria I. Rodriguez et al.
FREE RADICAL RESEARCH (2007)
The chemokine growth-regulated oncogene 1 (Gro-1) links RAS signaling to the senescence of stromal fibroblasts and ovarian tumorigenesis
Gong Yang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Gadd45a suppresses ras-driven mammary tumorigenesis by activation of c-Jun NH2-terminal kinase and p38 stress signaling resulting in apoptosis and senescence
Jennifer S. Tront et al.
CANCER RESEARCH (2006)
Modulation of canine immunosenescence by life-long caloric restriction
Elizabeth H. Greeley et al.
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY (2006)
Upregulation of chicken p15INK4b at senescence and in the developing brain
Soo-Hyun Kim et al.
JOURNAL OF CELL SCIENCE (2006)
DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
J Bartkova et al.
NATURE (2005)
Chronic oxidative stress compromises telomere integrity and accelerates the onset of senescence in human endothelial cells
DJ Kurz et al.
JOURNAL OF CELL SCIENCE (2004)
Nuclear accumulation of globular actin as a cellular senescence marker
IH Kwak et al.
CANCER RESEARCH (2004)
Ginsenoside-Rd attenuates oxidative damage related to aging in senescence-accelerated mice
T Yokozawa et al.
JOURNAL OF PHARMACY AND PHARMACOLOGY (2004)
The role of replicative senescence in chronic allograft nephropathy
S Ferlicot et al.
HUMAN PATHOLOGY (2003)
Uncoupling between phenotypic senescence and cell cycle arrest in aging p21-deficient fibroblasts
V Dulic et al.
MOLECULAR AND CELLULAR BIOLOGY (2000)
Is β-galactosidase staining a marker of senescence in vitro and in vivo?
J Severino et al.
EXPERIMENTAL CELL RESEARCH (2000)