☆ 4.8 Review

Antibodies to combat viral infections: development strategies and progress

NATURE REVIEWS DRUG DISCOVERY (2022)

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Review Immunology

Human Antibodies for Viral Infections

James E. Crowe

Summary: Antibodies have been widely used for preventing and treating viral infections since the nineteenth century, and the development of potent human monoclonal antibodies has paved the way for unprecedented activities. Modifications that extend antibody half-life and the clinical development of broad and potent antibodies have the potential to make antibodies the principal tool in managing future viral epidemics. Furthermore, these antibodies are crucial for research and developing effective vaccines.

ANNUAL REVIEW OF IMMUNOLOGY (2022)

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Article Biochemistry & Molecular Biology

The Omicron variant is highly resistant against antibody-mediated neutralization: Implications for control of the COVID-19 pandemic

Markus Hoffmann et al.

Summary: The Omicron variant of SARS-CoV-2 is spreading rapidly and shows resistance to most therapeutic antibodies. It also evades neutralization by antibodies induced by infection or vaccination more efficiently than the Delta variant. This suggests that therapeutic antibodies may not be effective against the Omicron variant, and double vaccination with BNT162b2 may not provide adequate protection against severe disease caused by this variant.

CELL (2022)

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Article Infectious Diseases

Efficacy and safety of two neutralising monoclonal antibody therapies, sotrovimab and BRII-196 plus BRII-198, for adults hospitalised with COVID-19 (TICO): a randomised controlled trial

Wesley H. Self et al.

Summary: This study assessed the efficacy and safety of two neutralising monoclonal antibody therapies for adults hospitalised with COVID-19. The results showed that neither of the therapies showed significant improvement in clinical outcomes among COVID-19 patients.

LANCET INFECTIOUS DISEASES (2022)

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Article Multidisciplinary Sciences

Striking antibody evasion manifested by the Omicron variant of SARS-CoV-2

Lihong Liu et al.

Summary: The B.1.1.529/Omicron variant of SARS-CoV-2, initially detected in southern Africa, has rapidly spread globally and is expected to become dominant due to its enhanced transmissibility in the coming weeks. This variant poses a threat to the efficacy of current COVID-19 vaccines and antibody therapies due to its significant antibody resistance. Even individuals who have received vaccines and booster doses may have reduced neutralizing activity against B.1.1.529.

NATURE (2022)

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Article Biochemistry & Molecular Biology

Safety and immunogenicity of a ferritin nanoparticle H2 influenza vaccine in healthy adults: a phase 1 trial

Katherine Houser et al.

Summary: This study evaluated the clinical trial results of a novel ferritin nanoparticle influenza vaccine platform called H2HA-Ferritin. The trial showed that the vaccine is safe and well tolerated, and it can elicit neutralizing antibody responses in both individuals who have not been exposed to the H2 subtype and those who have been exposed. Additionally, the vaccine also induced immune responses against multiple influenza subtypes. This vaccine technology has the potential for applications in pandemic preparedness and universal influenza vaccine development.

NATURE MEDICINE (2022)

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Article Biochemistry & Molecular Biology

An infectious SARS-CoV-2 B.1.1.529 Omicron virus escapes neutralization by therapeutic monoclonal antibodies

Laura A. VanBlargan et al.

Summary: The emergence of the B.1.1.529 Omicron variant raises concerns about the efficacy of antibody countermeasures. This study shows that some of the antibodies currently in clinical use may lose their ability to neutralize the Omicron variant.

NATURE MEDICINE (2022)

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Article Biochemistry & Molecular Biology

A single residue in influenza virus H2 hemagglutinin enhances the breadth of the B cell response elicited by H2 vaccination

Sarah F. Andrews et al.

Summary: Conserved epitopes on the influenza HA (hemagglutinin) stem are attractive targets for universal vaccine strategies. Differences in HA immunogens can affect the formation and expansion of broadly neutralizing memory B cells. These findings have implications for stem-based influenza vaccination strategies.

NATURE MEDICINE (2022)

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Article Cell Biology

The SARS-CoV-2 monoclonal antibody combination, AZD7442, is protective in nonhuman primates and has an extended half-life in humans

Yueh-Ming Loo et al.

Summary: AZD7442, a combination of two monoclonal antibodies, has the potential to prevent and treat COVID-19 by neutralizing the SARS-CoV-2 virus. It has shown encouraging results in preventing infection and accelerating virus clearance in animal models. The ongoing phase 1 study has also demonstrated its ability to provide long-lasting protection in healthy participants. This research is significant in providing additional options for COVID-19 prevention and treatment.

SCIENCE TRANSLATIONAL MEDICINE (2022)

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Article Multidisciplinary Sciences

A phase 2 single center open label randomised control trial for convalescent plasma therapy in patients with severe COVID-19

Yogiraj Ray et al.

Summary: A clinical trial was conducted involving 80 severe COVID-19 patients to assess the effectiveness of convalescent plasma therapy (CPT). The results showed that CPT did not affect mortality rate in severe COVID-19 patients, and there were no significant clinical benefits observed.

NATURE COMMUNICATIONS (2022)

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Article Multidisciplinary Sciences

A pandemic-enabled comparison of discovery platforms demonstrates a nai''ve antibody library can match the best immune-sourced antibodies

Fortunato Ferrara et al.

Summary: This study demonstrates that highly potent human neutralizing antibodies against the SARS-CoV-2 spike protein can be generated directly from a semisynthetic naive antibody library. These antibodies have comparable affinities, developability properties, and neutralization activities to those from immune sources, providing a potential alternative to traditional immunization methods.

NATURE COMMUNICATIONS (2022)

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Article Infectious Diseases

Influence of treatment with neutralizing monoclonal antibodies on the SARS-CoV-2 nasopharyngeal load and quasispecies

Camille Vellas et al.

Summary: The study evaluated the impact of neutralizing monoclonal antibody treatment and found that two-mAb therapy may drive the selection of resistant SARS-CoV-2 variants in immunocompromised patients. Emerging spike mutations were associated with stabilization or rebound of the NP viral load in some patients.

CLINICAL MICROBIOLOGY AND INFECTION (2022)

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News Item Infectious Diseases

Research in brief

Sharmila Devi

LANCET INFECTIOUS DISEASES (2022)

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Article Biochemistry & Molecular Biology

Serum neutralization of SARS-CoV-2 Omicron sublineages BA.1 and BA.2 in patients receiving monoclonal antibodies

Timothee Bruel et al.

Summary: There are differences in neutralizing activity of therapeutic antibodies against the SARS-CoV-2 Omicron BA.1 and BA.2 sublineages, and immunocompromised individuals treated with antibodies show elevated antibody levels but reduced neutralization against Omicron. Breakthrough infections with the Omicron variant are observed in some immunocompromised individuals despite antibody treatment.

NATURE MEDICINE (2022)

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Letter Medicine, General & Internal

Resistance Mutations in SARS-CoV-2 Delta Variant after Sotrovimab Use

Rebecca Rockett et al.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

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Article Medicine, General & Internal

Nirsevimab for Prevention of RSV in Healthy Late-Preterm and Term Infants

Laura L. Hammitt et al.

Summary: A single injection of nirsevimab administered before the RSV season protected healthy late-preterm and term infants from medically attended RSV-associated lower respiratory tract infection.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

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Article Cell Biology

LY-CoV1404 (bebtelovimab) potently neutralizes SARS-CoV-2 variants

Kathryn Westendorf et al.

Summary: A monoclonal antibody named LY-CoV1404 has been successfully isolated, which demonstrates highly potent neutralization against multiple variants of the SARS-CoV-2 virus. The binding site of LY-CoV1404 remains relatively conserved, allowing it to maintain its activity. This finding suggests that LY-CoV1404 has the potential to be an effective therapeutic agent against all known variants.

CELL REPORTS (2022)

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Article Multidisciplinary Sciences

Structural basis for HCMV Pentamer recognition by neuropilin 2 and neutralizing antibodies

Daniel Wrapp et al.

Summary: This study reveals the molecular mechanism of human cytomegalovirus (HCMV) infection. By analyzing the structures of HCMV and its cell receptor, the researchers discover a unique interaction that differs from previous studies. Furthermore, they identify the susceptible epitopes of HCMV, providing new insights for the development of antiviral drugs.

SCIENCE ADVANCES (2022)

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Article Multidisciplinary Sciences

Structural basis for HCMV Pentamer receptor recognition and antibody neutralization

Marc Kschonsak et al.

Summary: This study determines the structures of the Pentamer complex bound to NRP2 and a set of neutralizing antibodies against HCMV, and identifies THBD as a functional HCMV receptor. The results provide insights into HCMV receptor engagement, cell entry, and antibody neutralization, and outline strategies for antiviral therapies against HCMV.

SCIENCE ADVANCES (2022)

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Article Multidisciplinary Sciences

Antibody evasion properties of SARS-CoV-2 Omicron sublineages

Sho Iketani et al.

Summary: The identification of the Omicron variant of SARS-CoV-2 in Botswana in November 2021 sparked concern due to the spike protein alterations that could potentially evade antibodies. Further studies showed that the Omicron sublineages, BA.1+R346K and BA.2, are antigenically similar to the wild-type virus and pose similar risks to the effectiveness of current vaccines. BA.2 also demonstrated resistance to many neutralizing monoclonal antibodies, highlighting the challenges in developing effective therapeutic options.

NATURE (2022)

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Article Immunology

Suptavumab for the Prevention of Medically Attended Respiratory Syncytial Virus Infection in Preterm Infants

Eric A. F. Simoes et al.

Summary: The study indicates that suptavumab did not reduce the overall rate of childhood RSV respiratory infections due to a newly circulating mutant strain of RSV B. Genetic variation in circulating RSV strains will continue to pose challenges to prevention efforts.

CLINICAL INFECTIOUS DISEASES (2021)

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Article Biochemistry & Molecular Biology

Two-component spike nanoparticle vaccine protects macaques from SARS-CoV-2 infection

Philip J. M. Brouwer et al.

Summary: The study introduces a nanoparticle vaccine displaying multiple copies of the SARS-CoV-2 spike protein, which successfully induced potent antibody responses in mice, rabbits, and cynomolgus macaques. The vaccine-induced immunity protected macaques against a high-dose challenge, showing promising potential as a candidate to curtail the COVID-19 pandemic.

CELL (2021)

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Article Pharmacology & Pharmacy

REGN-EB3: First Approval

Anthony Markham

Summary: REGN-EB3, a combination of three fully-human monoclonal antibodies targeting Ebola virus glycoprotein, was recently approved by the US FDA based on the PALM study conducted during an Ebola outbreak in the Democratic Republic of Congo. This marks a significant milestone in the development of REGN-EB3 as a treatment for Zaire ebolavirus infection in adult and paediatric patients.

DRUGS (2021)

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Article Medicine, General & Internal

Effect of Bamlanivimab as Monotherapy or in Combination With Etesevimab on Viral Load in Patients With Mild to Moderate COVID-19 A Randomized Clinical Trial

Robert L. Gottlieb et al.

Summary: The study showed that treatment with bamlanivimab and etesevimab was significantly associated with a reduction in SARS-CoV-2 viral load at day 11 in nonhospitalized patients with mild to moderate COVID-19, compared to placebo. However, bamlanivimab monotherapy did not show a significant reduction in viral load. Ongoing clinical trials will focus on assessing the clinical benefits of antispike neutralizing antibodies in COVID-19 patients.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

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Review Allergy

Antibody therapy for COVID-19

Lennart Hammarstrom et al.

Summary: Antibody therapy for COVID-19 patients has shown great potential, especially with the use of monoclonal antibodies early in the disease process. Combining IgG monoclonal antibodies against the spike protein's receptor-binding domain appears to be the most effective form of antibody therapy, with promising results also seen with Immunoglobulin A dimers and Immunoglobulin M pentamers.

CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY (2021)

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Article Pharmacology & Pharmacy

Casirivimab/Imdevimab: First Approval

Emma D. Deeks

Summary: Casirivimab/imdevimab is a combination drug approved for the treatment and prevention of COVID-19 in several countries, including the USA, India, Canada, Switzerland, Japan, and the UK, with emergency use authorizations or conditional approvals granted for its use.

DRUGS (2021)

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Article Immunology

Antibody potency, effector function, and combinations in protection and therapy for SARS-CoV-2 infection in vivo

Alexandra Schafer et al.

Summary: The study shows that combined use of hu-mAbs is effective for prevention and therapy of SARS-CoV-2 infection, but in vivo protection is influenced by intact effector function.

JOURNAL OF EXPERIMENTAL MEDICINE (2021)

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Article Biochemistry & Molecular Biology

Modeling human adaptive immune responses with tonsil organoids

Lisa E. Wagar et al.

Summary: By utilizing human tonsils, researchers have developed a functional organotypic system that mimics key features of germinal centers in vitro, allowing for the study of humoral immune responses. This system not only enables a deeper understanding of critical mechanisms underlying adaptive immunity, but also facilitates rapid testing of vaccine candidates and adjuvants in an entirely human system.

NATURE MEDICINE (2021)

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Article Biochemistry & Molecular Biology

A chimeric hemagglutinin-based universal influenza virus vaccine approach induces broad and long-lasting immunity in a randomized, placebo-controlled phase I trial

Raffael Nachbagauer et al.

Summary: New influenza virus vaccines based on chimeric hemagglutinin have been found to induce a broad, strong, durable and functional immune response targeting the conserved stalk of the hemagglutinin protein. This suggests that these chimeric hemagglutinins have the potential to be developed as universal vaccines that protect broadly against influenza viruses.

NATURE MEDICINE (2021)

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Article Medicine, General & Internal

A Randomized Trial of Convalescent Plasma in Covid-19 Severe Pneumonia

V. A. Simonovich et al.

Summary: There were no significant differences observed in clinical status or overall mortality between patients treated with convalescent plasma and those who received placebo in the treatment of severe Covid-19 pneumonia. The study results indicate that both groups had similar clinical outcomes and mortality rates after 30 days.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Multidisciplinary Sciences

Unique structural solution from a VH3-30 antibody targeting the hemagglutinin stem of influenza A viruses

Wayne D. Harshbarger et al.

Summary: This study presents structural details of the human antibody 3I14 recognizing HA from various influenza A viruses, highlighting the binding mechanism and potential implications for universal vaccine design.

NATURE COMMUNICATIONS (2021)

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Article Biochemistry & Molecular Biology

Structures of HCMV Trimer reveal the basis for receptor recognition and cell entry

Marc Kschonsak et al.

Summary: HCMV uses a trimer to bind to PDGFR alpha and TGF beta R3, and the binding of these two receptors is mutually exclusive, indicating that they function as independent entry receptors. Additionally, the interaction between the trimer and PDGFR alpha inhibits PDGFR alpha signaling.

CELL (2021)

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Article Biochemistry & Molecular Biology

Human neutralizing antibodies against SARS-CoV-2 require intact Fc effector functions for optimal therapeutic protection

Emma S. Winkler et al.

Summary: This study found that neutralizing human monoclonal antibodies in SARS-CoV-2-infected animals require Fc effector functions for optimal protection, reducing inflammation, improving respiratory mechanics, and being associated with diminished immune signaling and tissue repair.

CELL (2021)

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Article Microbiology

Potent SARS-CoV-2 neutralizing antibodies directed against spike N-terminal domain target a single supersite

Gabriele Cerutti et al.

Summary: Structural analysis revealed that seven potent NTD-directed neutralizing antibodies target a common surface on NTD, forming a single supersite different from the recognition pattern of RBD-directed antibodies.

CELL HOST & MICROBE (2021)

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Article Medicine, General & Internal

Early Treatment for Covid-19 with SARS-CoV-2 Neutralizing Antibody Sotrovimab

Anil Gupta et al.

Summary: In this study, among nonhospitalized patients with symptomatic Covid-19, sotrovimab treatment significantly reduced the risk of disease progression leading to hospitalization or death compared to placebo. Patients receiving sotrovimab also had a lower rate of serious adverse events.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Virology

Early T cell reconstitution and cytokine profile may help to guide a personalized management of human cytomegalovirus infection after allogeneic hematopoietic stem cell transplantation

Elisa Gabanti et al.

Summary: This retrospective study found that HSCT recipients who spontaneously controlled HCMV reactivation had higher CD4(+) and CD8(+) T-cell counts and lower percentage of HCMV-specific T-cells. The only baseline characteristic associated with clinically significant infection was an HCMV-seronegative donor.

JOURNAL OF CLINICAL VIROLOGY (2021)

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Article Cell Biology

Broad neutralization of H1 and H3 viruses by adjuvanted influenza HA stem vaccines in nonhuman primates

Nicole Darricarrere et al.

Summary: Seasonal influenza vaccines offer protection against specific strains but have limitations. H1 and H3 subtypes of influenza A virus cause most seasonal epidemics. A new study shows that vaccines with headless HA stabilized-stem can elicit broadly neutralizing antibody responses to various H1 and H3 viruses in nonhuman primates.

SCIENCE TRANSLATIONAL MEDICINE (2021)

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Review Immunology

Single B cell technologies for monoclonal antibody discovery

Alessandro Pedrioli et al.

Summary: This review presents and discusses the major techniques available to interrogate antigen-specific single B cells to isolate antigen-specific mAbs, including methods for retrieving antibody-coding sequences and generating mAbs independently of antigen-specific B cells. The review also highlights the advantages and disadvantages of these techniques.

TRENDS IN IMMUNOLOGY (2021)

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Article Cell Biology

Metabolic programs define dysfunctional immune responses in severe COVID-19 patients

Elizabeth A. Thompson et al.

Summary: The study identifies a unique population of T cells expressing increased VDAC1 in severe and recovered COVID-19 patients, associated with mitochondrial dysfunction and apoptosis. Additionally, specific metabolic phenotypes of myeloid-derived suppressor cells in COVID-19 patients can distinguish between severe and mild disease. These findings offer insight into dysfunctional immune response in COVID-19 patients and potential for developing personalized therapeutic approaches.

CELL REPORTS (2021)

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Article Multidisciplinary Sciences

Cross-neutralizing antibodies bind a SARS-CoV-2 cryptic site and resist circulating variants

Tingting Li et al.

Summary: The study identified two cross-neutralizing antibodies targeting the receptor-binding domain of SARS-CoV-2, which can effectively neutralize various virus variants, providing potential options for public health interventions.

NATURE COMMUNICATIONS (2021)

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Review Immunology

Structure-guided envelope trimer design in HIV-1 vaccine development: a narrative review

Ronald Derking et al.

Summary: The development of an effective HIV-1 vaccine is a major challenge, requiring the induction of broadly neutralizing antibodies through the use of native-like HIV-1 envelope trimers. Progress in understanding and improving Env trimers through structural biology has been crucial for vaccine design, accelerating the iterative process and enhancing on-target antibody responses.

JOURNAL OF THE INTERNATIONAL AIDS SOCIETY (2021)

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Article Multidisciplinary Sciences

Prefusion structure of human cytomegalovirus glycoprotein B and structural basis for membrane fusion

Yuhang Liu et al.

Summary: The study stabilized the prefusion state of HCMV glycoprotein B (gB) and determined its structure, revealing the details of membrane fusion and interactions among key components. This high-resolution prefusion gB structure provides a basis for developing stabilized prefusion gB HCMV vaccine antigens.

SCIENCE ADVANCES (2021)

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Article Immunology

Prolonged evolution of the human B cell response to SARS-CoV-2 infection

Mrunal Sakharkar et al.

Summary: The study on the kinetics and evolution of the human B cell response to SARS-CoV-2 infection revealed that serum neutralizing antibody responses declined rapidly, while spike-specific IgG(+) memory B cells remained stable or increased over time. The research also showed evidence for prolonged antibody affinity maturation and the impact of mutations in the S protein on the neutralizing antibody response.

SCIENCE IMMUNOLOGY (2021)

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Article Biochemistry & Molecular Biology

Neutralizing and protective human monoclonal antibodies recognizing the N-terminal domain of the SARS-CoV-2 spike protein

Naveenchandra Suryadevara et al.

Summary: The study found that a subset of human monoclonal antibodies derived from convalescent SARS-CoV-2 patients possess neutralizing activity, with two antibodies capable of inhibiting infection. Mechanistic studies revealed these antibodies neutralize in part by inhibiting post-attachment steps in the infection cycle.

CELL (2021)

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Article Biochemistry & Molecular Biology

N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2

Matthew McCallum et al.

Summary: The study identifies 41 human monoclonal antibodies that recognize the N-terminal domain of the SARS-CoV-2 spike protein and exhibit strong neutralizing activity. These antibodies inhibit cell-to-cell fusion, activate effector functions, and protect animals from virus challenge, highlighting the importance of NTD-specific neutralizing antibodies for protective immunity and vaccine development. Several SARS-CoV-2 variants with mutations in the NTD supersite suggest ongoing selective pressure on the virus.

CELL (2021)

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Article Biochemistry & Molecular Biology

Progress toward improved understanding of antibody maturation

Sandor Vajda et al.

Summary: Recent progress in antibody maturation studies has focused on four areas: the use of next-generation and single-cell sequencing technologies to analyze antibody repertoires, the availability of structural and biophysical data to understand mechanisms behind improved affinity, the fundamental functions of the immune system related to diversity and discrimination, and the application of in vivo maturation results to develop in vitro methods for therapeutic antibody improvement.

CURRENT OPINION IN STRUCTURAL BIOLOGY (2021)

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Article Pharmacology & Pharmacy

Ansuvimab: First Approval

Arnold Lee

Summary: Ansuvimab, developed by Ridgeback Biotherapeutics, is a human monoclonal antibody approved in the USA for treating Zaire ebolavirus infection in both adult and paediatric patients. It blocks the entry of Ebola virus into host cells by binding to the virus glycoprotein.

DRUGS (2021)

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Article Immunology

Immune dysregulation and autoreactivity correlate with disease severity in SARS-CoV-2-associated multisystem inflammatory syndrome in children

Anjali Ramaswamy et al.

Summary: Through various analyses, specific biological features were identified in MIS-C patients, including myeloid dysfunction, elevated cytotoxicity gene expression in NK and CD8(+) T cells, and autoimmune characteristics, which could potentially improve the diagnosis and prediction of disease severity in MIS-C.

IMMUNITY (2021)

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Article Multidisciplinary Sciences

Quadrivalent influenza nanoparticle vaccines induce broad protection

Seyhan Boyoglu-Barnum et al.

Summary: Computational design of nanoparticle immunogens can induce potent and broad antibody responses against diverse influenza viruses, including neutralizing antibody responses to vaccine-matched strains and broadly protective antibody responses to heterologous viruses. These novel vaccines have the potential to replace traditional seasonal vaccines.

NATURE (2021)

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News Item Biotechnology & Applied Microbiology

FDA approves 100th monoclonal antibody product

Asher Mullard

Summary: After 35 years since the FDA approved the first monoclonal antibody, these biologics now make up nearly one fifth of the agency's new drug approvals each year.

NATURE REVIEWS DRUG DISCOVERY (2021)

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Article Cell Biology

The neutralizing antibody, LY-CoV555, protects against SARS-CoV-2 infection in nonhuman primates

Bryan E. Jones et al.

Summary: LY-CoV555 is a novel neutralizing antibody derived from a convalescent patient with COVID-19, showing high affinity binding, potent inhibition of ACE2 binding, and strong neutralizing activity. This antibody has entered clinical trials and is being evaluated for various COVID-19 prevention and treatment indications.

SCIENCE TRANSLATIONAL MEDICINE (2021)

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Article Multidisciplinary Sciences

Single-component multilayered self-assembling nanoparticles presenting rationally designed glycoprotein trimers as Ebola virus vaccines

Linling He et al.

Summary: The study identifies mutations to improve GP stability and yield, designs two multilayered nanoparticle carriers, and demonstrates good immunogenicity of the modified GP on nanoparticles in mice and rabbits.

NATURE COMMUNICATIONS (2021)

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Article Biology

Improving oligo-conjugated antibody signal in multimodal single-cell analysis

Terkild B. Buus et al.

Summary: The study demonstrates the impact of adjusting antibody concentrations on improving signal, reducing background, and lowering costs, while reducing staining volume specifically affects antibodies targeting abundant epitopes used at low concentrations and can be counteracted by reducing cell numbers. Background signal from high concentration antibodies can constitute a major fraction of total sequencing.

ELIFE (2021)

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Article Biochemistry & Molecular Biology

Therapeutic effect of CT-P59 against SARS-CoV-2 South African variant

Dong-Kyun Ryu et al.

Summary: The global spread of newly emerging variants of SARS-CoV-2 poses a new threat to public health, with vaccines and antibodies showing reduced effectiveness against these variants. Research has shown that while the CT-P59 monoclonal antibody has reduced neutralizing activity against the South African variant in vitro, it is still able to decrease viral load in animals infected with the variant in vivo.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2021)

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Article Multidisciplinary Sciences

Nanobodies from camelid mice and llamas neutralize SARS-CoV-2 variants

Jianliang Xu et al.

Summary: The study found that camelid nanobodies can effectively circumvent vaccine escape caused by mutations in the novel coronavirus. These nanobodies are able to neutralize SARS-CoV-2 variants through two mechanisms, demonstrating promising potential in preventing COVID-19 mortality when vaccines are compromised.

NATURE (2021)

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Article Immunology

Coupled analysis of transcriptome and BCR mutations reveals role of OXPHOS in affinity maturation

Dianyu Chen et al.

Summary: Through single-cell transcriptomic analyses, researchers found that GC B cells with higher-affinity mutations had increased expression of OXPHOS genes. Deletion of mitochondrial genes in GC B cells resulted in reduced cell division and impaired positive selection. Enhancement of OXPHOS activity promoted affinity maturation in GC B cells.

NATURE IMMUNOLOGY (2021)

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Article Biochemistry & Molecular Biology

Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial

Philippe Begin et al.

Summary: Convalescent plasma did not reduce the risk of intubation or death at 30 days in hospitalized patients with COVID-19. Transfusion of convalescent plasma with unfavorable antibody profiles could be associated with worse clinical outcomes compared to standard care.

NATURE MEDICINE (2021)

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Review Microbiology

Pathogenesis of human cytomegalovirus in the immunocompromised host

Paul Griffiths et al.

Summary: HCMV infection is usually controlled by a vigorous immune response, but can cause serious organ diseases when the immune system is compromised. Significant progress has been made in understanding HCMV infection and disease, including defining the dynamics of viral replication and evaluating new antiviral drugs and vaccines.

NATURE REVIEWS MICROBIOLOGY (2021)

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Article Medicine, General & Internal

Bamlanivimab plus Etesevimab in Mild or Moderate Covid-19

M. Dougan et al.

Summary: In this phase 3 trial, the combination of bamlanivimab plus etesevimab was found to reduce the incidence of Covid-19-related hospitalization and death among high-risk ambulatory patients compared to placebo, and also accelerated the decline in SARS-CoV-2 viral load.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Medicine, General & Internal

Subcutaneous REGEN-COV Antibody Combination to Prevent Covid-19

M. P. O'Brien et al.

Summary: The study indicates that subcutaneous REGEN-COV can effectively prevent severe Covid-19 and reduce the duration of symptoms in individuals at high risk for infection due to household exposure to confirmed SARS-CoV-2 cases.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Multidisciplinary Sciences

Broad betacoronavirus neutralization by a stem helix-specific human antibody

Dora Pinto et al.

Summary: The study identified five monoclonal antibodies from COVID-19 convalescent individuals that cross-react with multiple betacoronavirus spike glycoproteins, with one antibody (S2P6) showing broad neutralization of viruses from three different subgenera. This antibody reduced viral burden in hamsters challenged with SARS-CoV-2 by inhibiting membrane fusion, providing a framework for the design of pan-betacoronavirus vaccines for broad protection.

SCIENCE (2021)

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Article Cell Biology

A highly potent antibody effective against SARS-CoV-2 variants of concern

Craig Fenwick et al.

Summary: The research has identified a monoclonal antibody called P5C3 with highly potent neutralizing activity against all SARS-CoV-2 variants identified to date, showing promising potential as a prophylactic agent or combination therapy for individuals with poor response to vaccination.

CELL REPORTS (2021)

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Article Cell Biology

Potent neutralization of SARS-CoV-2 variants of concern by an antibody with an uncommon genetic signature and structural mode of spike recognition

Kevin J. Kramer et al.

Summary: The emergence of SARS-CoV-2 lineages with increased transmissibility and resistance to antibody therapies poses a challenge to COVID-19 treatment. A panel of antibodies, with 54042-4 showing potent neutralization against SARS-CoV-2, including variants of concern, has been isolated using LIBRA-seq technology. The unique genetic and structural characteristics of 54042-4 make it a promising candidate for combating current and future SARS-CoV-2 variants.

CELL REPORTS (2021)

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Article Biology

Parallel evolution between genomic segments of seasonal human influenza viruses reveals RNA-RNA relationships

Jennifer E. Jones et al.

Summary: Influenza viruses evolve rapidly during infection through mutations or reassortment, potentially leading to strains with increased resistance or infectivity. Understanding how genome segments interact during reassortment can help predict future events and emergence of new pandemic strains. Research in this area could provide valuable insights for risk assessment and pandemic preparedness.

ELIFE (2021)

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Article Microbiology

Genetic and structural basis for SARS-CoV-2 variant neutralization by a two-antibody cocktail

Jinhui Dong et al.

Summary: Structural analysis of two human monoclonal antibodies forming the antibody cocktail AZD7442, when bound to the RBD of SARS-CoV-2, demonstrates strong neutralization of variants of concern. Genetic and structural basis of neutralization has been defined, revealing crucial binding residues and positions of concern for virus escape. These germ line-encoded antibody features enable recognition of SARS-CoV-2 spike RBD and showcase the utility of cocktail AZD7442 in neutralizing emerging variant viruses.

NATURE MICROBIOLOGY (2021)

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Review Immunology

Antibody dependent enhancement: Unavoidable problems in vaccine development

Lele Xu et al.

Summary: ADE refers to the phenomenon in which antibodies enhance the entry and replication of viruses in cells. While there is no direct evidence of ADE in COVID-19, early vaccines have been shown to induce this phenomenon. Research focuses on understanding ADE and proposing vaccine development strategies to avoid it.

ADVANCES IN IMMUNOLOGY, VOL 151 (2021)

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Article Immunology

Immunological mechanisms of vaccine-induced protection against COVID-19 in humans

Manish Sadarangani et al.

Summary: Most COVID-19 vaccines aim to induce immune responses, particularly neutralizing antibodies (NAbs), against the spike protein of the virus. mRNA vaccines have shown efficacy after just one dose, while adenovirus vaccines elicit polyfunctional antibodies and strong T cell responses. These findings suggest that protection may not solely rely on NAbs but also involve other immune effector mechanisms.

NATURE REVIEWS IMMUNOLOGY (2021)

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Review Immunology

Neutralizing monoclonal antibodies for treatment of COVID-19

Peter C. Taylor et al.

Summary: The study discusses the clinical utility of neutralizing monoclonal antibody therapies targeting SARS-CoV-2, emphasizing the importance of patient stratification, biomarkers, risk factors, and other clinical considerations.

NATURE REVIEWS IMMUNOLOGY (2021)

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Review Microbiology

Coronavirus biology and replication: implications for SARS-CoV-2

Philip V'kovski et al.

Summary: This review discusses key aspects of coronavirus biology and their implications for SARS-CoV-2 infections, treatment, and prevention strategies. Understanding virus-host interactions at the molecular level is crucial for developing effective intervention strategies. Summarizing the discoveries of SARS-CoV-2 infection and comparing it with other coronaviruses will support future preparedness and combat strategies.

NATURE REVIEWS MICROBIOLOGY (2021)

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Article Medicine, General & Internal

A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster

Jasper Fuk-Woo Chan et al.

LANCET (2020)

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Article Multidisciplinary Sciences

A pneumonia outbreak associated with a new coronavirus of probable bat origin

Peng Zhou et al.

NATURE (2020)

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Article Biotechnology & Applied Microbiology

Polymer-stabilized Cas9 nanoparticles and modified repair templates increase genome editing efficiency

David N. Nguyen et al.

NATURE BIOTECHNOLOGY (2020)

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Review Biotechnology & Applied Microbiology

Next-generation influenza vaccines: opportunities and challenges

Chih-Jen Wei et al.

NATURE REVIEWS DRUG DISCOVERY (2020)

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Article Medicine, General & Internal

A Novel Coronavirus from Patients with Pneumonia in China, 2019

Na Zhu et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Multidisciplinary Sciences

Divergent evolutionary trajectories of influenza B viruses underlie their contemporaneous epidemic activity

Ramandeep K. Virk et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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Article Multidisciplinary Sciences

Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

Daniel Wrapp et al.

SCIENCE (2020)

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Article Biochemistry & Molecular Biology

Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein

Alexandra C. Walls et al.

CELL (2020)

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Article Immunology

Potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific human monoclonal antibody

Xiaolong Tian et al.

EMERGING MICROBES & INFECTIONS (2020)

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Article Multidisciplinary Sciences

De novo protein design enables the precise induction of RSV-neutralizing antibodies

Fabian Sesterhenn et al.

SCIENCE (2020)

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Article Multidisciplinary Sciences

A facile technology for the high-throughput sequencing of the paired VH:VL and TCRβ:TCRα repertoires

Hidetaka Tanno et al.

SCIENCE ADVANCES (2020)

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Article Multidisciplinary Sciences

A human neutralizing antibody targets the receptor-binding site of SARS-CoV-2

Rui Shi et al.

NATURE (2020)

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Article Multidisciplinary Sciences

Human neutralizing antibodies elicited by SARS-CoV-2 infection

Bin Ju et al.

NATURE (2020)

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Article Multidisciplinary Sciences

Cross-neutralization ofSARS-CoV-2 by a human monoclonal SARS-CoV antibody

Dora Pinto et al.

NATURE (2020)

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Article Multidisciplinary Sciences

Structural basis of receptor recognition by SARS-CoV-2

Jian Shang et al.

NATURE (2020)

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Article Microbiology

A Combination of Human Broadly Neutralizing Antibodies against Hepatitis B Virus HBsAg with Distinct Epitopes Suppresses Escape Mutations

Qiao Wang et al.

CELL HOST & MICROBE (2020)

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Article Biochemistry & Molecular Biology

The protein expression profile of ACE2 in human tissues

Feria Hikmet et al.

MOLECULAR SYSTEMS BIOLOGY (2020)

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Article Biochemistry & Molecular Biology

A Therapeutic Non-self-reactive SARS-CoV-2 Antibody Protects from Lung Pathology in a COVID-19 Hamster Model

Jakob Kreye et al.

CELL (2020)

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Article Biochemistry & Molecular Biology

Structurally Resolved SARS-CoV-2 Antibody Shows High Efficacy in Severely Infected Hamsters and Provides a Potent Cocktail Pairing Strategy

Shuo Du et al.

CELL (2020)

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Article Multidisciplinary Sciences

Potent neutralizing antibodies against multiple epitopes on SARS-CoV-2 spike

Lihong Liu et al.

NATURE (2020)

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Article Multidisciplinary Sciences

Potently neutralizing and protective human antibodies against SARS-CoV-2

Seth J. Zost et al.

NATURE (2020)

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Article Multidisciplinary Sciences

A perspective on potential antibody-dependent enhancement of SARS-CoV-2

Ann M. Arvin et al.

NATURE (2020)

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Article Biochemistry & Molecular Biology

Structural basis for the neutralization of SARS-CoV-2 by an antibody from a convalescent patient

Daming Zhou et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2020)

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Article Medicine, General & Internal

Single-Dose Nirsevimab for Prevention of RSV in Preterm Infants

M. Pamela Griffin et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Multidisciplinary Sciences

A neutralizing human antibody binds to the N-terminal domain of the Spike protein of SARS-CoV-2

Xiangyang Chi et al.

SCIENCE (2020)

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Article Multidisciplinary Sciences

Antibody cocktail to SARS-CoV-2 spike protein prevents rapid mutational escape seen with individual antibodies

Alina Baum et al.

SCIENCE (2020)

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Article Multidisciplinary Sciences

Studies in humanized mice and convalescent humans yield a SARS-CoV-2 antibody cocktail

Johanna Hansen et al.

SCIENCE (2020)

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Article Multidisciplinary Sciences

Distinct conformational states of SARS-CoV-2 spike protein

Yongfei Cai et al.

SCIENCE (2020)

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Article Multidisciplinary Sciences

Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability

Philip J. M. Brouwer et al.

SCIENCE (2020)

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Article Biochemistry & Molecular Biology

Computationally Designed Cyclic Peptides Derived from an Antibody Loop Increase Breadth of Binding for Influenza Variants

Alexander M. Sevy et al.

STRUCTURE (2020)

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Article Biochemistry & Molecular Biology

Identification of Structurally Related Antibodies in Antibody Sequence Databases Using Rosetta-Derived Position-Specific Scoring

Jessica A. Finn et al.

STRUCTURE (2020)

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Article Biochemical Research Methods

AncesTree: An interactive immunoglobulin lineage tree visualizer

Mathilde Foglierini et al.

PLOS COMPUTATIONAL BIOLOGY (2020)

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Article Multidisciplinary Sciences

Fc-optimized antibodies elicit CD8 immunity to viral respiratory infection

Stylianos Bournazos et al.

NATURE (2020)

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Article Multidisciplinary Sciences

SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies

Christopher O. Barnes et al.

NATURE (2020)

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Article Multidisciplinary Sciences

REGN-COV2 antibodies prevent and treat SARS-CoV-2 infection in rhesus macaques and hamsters

Alina Baum et al.

SCIENCE (2020)

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Article Multidisciplinary Sciences

Viral epitope profiling of COVID-19 patients reveals cross-reactivity and correlates of severity

Ellen Shrock et al.

SCIENCE (2020)

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Article Multidisciplinary Sciences

Ultrapotent human antibodies protect against SARS-CoV-2 challenge via multiple mechanisms

M. Alejandra Tortorici et al.

SCIENCE (2020)

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Article Cell Biology

Identification and Structure of a Multidonor Class of Head-Directed Influenza-Neutralizing Antibodies Reveal the Mechanism for Its Recurrent Elicitation

Crystal Sao-Fong Cheung et al.

CELL REPORTS (2020)

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Article Cell Biology

An Alternative Binding Mode of IGHV3-53 Antibodies to the SARS-CoV-2 Receptor Binding Domain

Nicholas C. Wu et al.

CELL REPORTS (2020)

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Review Microbiology

Antibody-dependent enhancement and SARS-CoV-2 vaccines and therapies

Wen Shi Lee et al.

NATURE MICROBIOLOGY (2020)

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Letter Medicine, General & Internal

Persistence and Evolution of SARS-CoV-2 in an Immunocompromised Host

Bina Choi et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

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Article Microbiology

Rationally designed Human Cytomegalovirus gB nanoparticle vaccine with improved immunogenicity

Michela Perotti et al.

PLOS PATHOGENS (2020)

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Article Immunology

Rapid generation of durable B cell memory to SARS-CoV-2 spike and nucleocapsid proteins in COVID-19 and convalescence

Gemma E. Hartley et al.

SCIENCE IMMUNOLOGY (2020)

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Review Infectious Diseases

Monoclonal Antibodies as an Antibacterial Approach Against Bacterial Pathogens

Daniel V. Zurawski et al.

ANTIBIOTICS-BASEL (2020)

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Review Immunology

The role of IgG Fc receptors in antibody-dependent enhancement

Stylianos Bournazos et al.

NATURE REVIEWS IMMUNOLOGY (2020)

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Article Biochemistry & Molecular Biology

Induction of Potent Neutralizing Antibody Responses by a Designed Protein Nanoparticle Vaccine for Respiratory Syncytial Virus

Jessica Marcandalli et al.

CELL (2019)

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Article Immunology

Human Memory B Cells Harbor Diverse Cross-Neutralizing Antibodies against BK and JC Polyomaviruses

John M. Lindner et al.

IMMUNITY (2019)

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Article Immunology

Safety and Immunogenicity of a 2-Dose Heterologous Vaccine Regimen With Ad26.ZEBOV and MVA-BN-Filo Ebola Vaccines: 12-Month Data From a Phase 1 Randomized Clinical Trial in Nairobi, Kenya

Gaudensia Mutua et al.

JOURNAL OF INFECTIOUS DISEASES (2019)

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Review Medicine, General & Internal

Ebola virus disease

Denis Malvy et al.

LANCET (2019)

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Article Immunology

Mosaic nanoparticle display of diverse influenza virus hemagglutinins elicits broad B cell responses

Masaru Kanekiyo et al.

NATURE IMMUNOLOGY (2019)

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Review Biochemistry & Molecular Biology

Current and future influenza vaccines

Seiya Yamayoshi et al.

NATURE MEDICINE (2019)

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Review Microbiology

Respiratory syncytial virus entry and how to block it

Michael B. Battles et al.

NATURE REVIEWS MICROBIOLOGY (2019)

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Article Multidisciplinary Sciences

Egg-based influenza split virus vaccine with monoglycosylation induces cross-strain protection against influenza virus infections

Yung-Chieh Tseng et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

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Article Microbiology

Design of Nanoparticulate Group 2 Influenza Virus Hemagglutinin Stem Antigens That Activate Unmutated Ancestor B Cell Receptors of Broadly Neutralizing Antibody Lineages

Kizzmekia S. Corbett et al.

MBIO (2019)

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Article Biochemistry & Molecular Biology

Boosting subdominant neutralizing antibody responses with a computationally designed epitope-focused immunogen

Fabian Sesterhenn et al.

PLOS BIOLOGY (2019)

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Article Biochemistry & Molecular Biology

A Site of Vulnerability on the Influenza Virus Hemagglutinin Head Domain Trimer Interface

Sandhya Bangaru et al.

CELL (2019)

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Article Microbiology

Influenza Antigen Engineering Focuses Immune Responses to a Subdominant but Broadly Protective Viral Epitope

Goran Bajic et al.

CELL HOST & MICROBE (2019)

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Review Biochemistry & Molecular Biology

Broadly neutralizing anti-HIV-1 monoclonal antibodies in the clinic

Marina Caskey et al.

NATURE MEDICINE (2019)

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Article Multidisciplinary Sciences

Protect, modify, deprotect (PMD): A strategy for creating vaccines to elicit antibodies targeting a specific epitope

Payton A. Weidenbacher et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

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Article Cell Biology

Therapeutic Monoclonal Antibodies for Ebola Virus Infection Derived from Vaccinated Humans

Pramila Rijal et al.

CELL REPORTS (2019)

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Article Microbiology

HCMV Envelope Glycoprotein Diversity Demystified

Mathilde Foglierini et al.

FRONTIERS IN MICROBIOLOGY (2019)

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Review Infectious Diseases

Monoclonal antibody-based therapies for bacterial infections

Michael P. Motley et al.

CURRENT OPINION IN INFECTIOUS DISEASES (2019)

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Review Biotechnology & Applied Microbiology

Bispecific antibodies: a mechanistic review of the pipeline

Aran F. Labrijn et al.

NATURE REVIEWS DRUG DISCOVERY (2019)

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Review Immunology

Targeting broadly neutralizing antibody precursors: a naive approach to vaccine design

Andrew T. McGuire

CURRENT OPINION IN HIV AND AIDS (2019)

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Article Medicine, Research & Experimental

Antibodies targeting sialyl Lewis A mediate tumor clearance through distinct effector pathways

Polina Weitzenfeld et al.

JOURNAL OF CLINICAL INVESTIGATION (2019)

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Review Cell Biology

Advances in protein structure prediction and design

Brian Kuhlman et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)

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Editorial Material Cell Biology

Multiple roles for HIV broadly neutralizing antibodies

Barton F. Haynes et al.

SCIENCE TRANSLATIONAL MEDICINE (2019)

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Article Virology

The potential of engineered antibodies for HIV-1 therapy and cure

Marloes Grobben et al.

CURRENT OPINION IN VIROLOGY (2019)

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Article Biochemistry & Molecular Biology

High-Throughput Mapping of B Cell Receptor Sequences to Antigen Specificity

Ian Setliff et al.

CELL (2019)

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Article Immunology

Immunodominance and Antigenic Variation of Influenza Virus Hemagglutinin: Implications for Design of Universal Vaccine Immunogens

Seth J. Zost et al.

JOURNAL OF INFECTIOUS DISEASES (2019)

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Article Medicine, General & Internal

Caplacizumab Treatment for Acquired Thrombotic Thrombocytopenic Purpura

M. Scully et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

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Review Biochemistry & Molecular Biology

Fighting Staphylococcus aureus Biofilms with Monoclonal Antibodies

Dina Raafat et al.

TRENDS IN MICROBIOLOGY (2019)

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Article Biochemistry & Molecular Biology

Structures of MERS-CoV spike glycoprotein in complex with sialoside attachment receptors

Young-Jun Park et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2019)

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Article Medicine, General & Internal

A Randomized, Controlled Trial of Ebola Virus Disease Therapeutics

Sabue Mulangu et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

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Article Multidisciplinary Sciences

Viral neutralization by antibody-imposed physical disruption

Qingbing Zheng et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

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Review Immunology

The human antibody response to influenza A virus infection and vaccination

Florian Krammer

NATURE REVIEWS IMMUNOLOGY (2019)

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Article Biochemistry & Molecular Biology

Structure-based immunogen design - leading the way to the new age of precision vaccines

Fabian Sesterhenn et al.

CURRENT OPINION IN STRUCTURAL BIOLOGY (2018)

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Article Immunology

Memory B Cells that Cross-React with Group 1 and Group 2 Influenza A Viruses Are Abundant in Adult Human Repertoires

Kevin R. McCarthy et al.

IMMUNITY (2018)

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Article Virology

Human coronavirus circulation in the United States 2014-2017

Marie E. Killerby et al.

JOURNAL OF CLINICAL VIROLOGY (2018)

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Article Immunology

Vaccine Generation of Protective Ebola Antibodies and Identification of Conserved B-Cell Signatures

Alberto Cagigi et al.

JOURNAL OF INFECTIOUS DISEASES (2018)

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Article Immunology

Development of Clinical-Stage Human Monoclonal Antibodies That Treat Advanced Ebola Virus Disease in Nonhuman Primates

Kristen E. Pascal et al.

JOURNAL OF INFECTIOUS DISEASES (2018)

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Article Virology

Human cytomegalovirus (HCMV)-specific T cell but not neutralizing or IgG binding antibody responses to glycoprotein complexes gB, gHgLgO, and pUL128L correlate with protection against high HCMV viral load reactivation in solid-organ transplant recipients

Daniele Lilleri et al.

JOURNAL OF MEDICAL VIROLOGY (2018)

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Review Biochemistry & Molecular Biology

Structural insights into the design of novel anti-influenza therapies

Nicholas C. Wu et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2018)

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Article Immunology

Safety, Tolerability and Pharmacokinetics of MEDI8897, an Extended Half-life Single-dose Respiratory Syncytial Virus Prefusion F-targeting Monoclonal Antibody Administered as a Single Dose to Healthy Preterm Infants

Joseph B. Domachowske et al.

PEDIATRIC INFECTIOUS DISEASE JOURNAL (2018)

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Article Multidisciplinary Sciences

HCMV glycoprotein B subunit vaccine efficacy mediated by nonneutralizing antibody effector functions

Cody S. Nelson et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

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Review Biochemistry & Molecular Biology

Structural insights into the design of novel anti-influenza therapies

Nicholas C. Wu et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2018)

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Article Medicine, General & Internal

Safety and pharmacokinetics of the Fc-modified HIV-1 human monoclonal antibody VRC01LS: A Phase 1 open-label clinical trial in healthy adults

Martin R. Gaudinski et al.

PLOS MEDICINE (2018)

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Article Immunology

Mini-hemagglutinin vaccination induces cross-reactive antibodies in pre-exposed NHP that protect mice against lethal influenza challenge

Joan E. M. van der Lubbe et al.

NPJ VACCINES (2018)

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Article Biochemistry & Molecular Biology

An Unbiased Screen for Human Cytomegalovirus Identifies Neuropilin-2 as a Central Viral Receptor

Nadia Martinez-Martin et al.

CELL (2018)

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Review Immunology

Recent progress in broadly neutralizing antibodies to HIV

Devin Sok et al.

NATURE IMMUNOLOGY (2018)

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Review Immunology

Beyond binding: antibody effector functions in infectious diseases

Lenette L. Lu et al.

NATURE REVIEWS IMMUNOLOGY (2018)

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Article Immunology

Phase 1 Study Evaluating Safety, Tolerability, Pharmacokinetics and Immunogenicity of REGN2222 in Healthy Adults: A New Human Monoclonal RSV-F Antibody for RSV Prevention

Sumathi Sivapalasingam et al.

Open Forum Infectious Diseases (2017)

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Review Immunology

Identification and specificity of broadly neutralizing antibodies against HIV

Laura E. McCoy et al.

IMMUNOLOGICAL REVIEWS (2017)

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Article Medicine, General & Internal

Efficacy and effectiveness of an rVSV-vectored vaccine in preventing Ebola virus disease: final results from the Guinea ring vaccination, open-label, cluster-randomised trial (Ebola Ca Suffit!)

Ana Maria Henao-Restrepo et al.

LANCET (2017)

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Article Medicine, General & Internal

Chimpanzee Adenovirus Vector Ebola Vaccine

Julie E. Ledgerwood et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

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Article Medicine, General & Internal

Bezlotoxumab for Prevention of Recurrent Clostridium difficile Infection

M. H. Wilcox et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

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Article Multidisciplinary Sciences

Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen

Jesper Pallesen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

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Article Multidisciplinary Sciences

Trispecific broadly neutralizing HIV antibodies mediate potent SHIV protection in macaques

Ling Xu et al.

SCIENCE (2017)

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Editorial Material Cell Biology

What Are the Most Powerful Immunogen Design Vaccine Strategies? Reverse Vaccinology 2.0 Shows Great Promise

Dennis R. Burton

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2017)

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Article Multidisciplinary Sciences

Structural basis of respiratory syncytial virus subtype-dependent neutralization by an antibody targeting the fusion glycoprotein

Daiyin Tian et al.

NATURE COMMUNICATIONS (2017)

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Article Medicine, Research & Experimental

Preexisting antibodies can protect against congenital cytomegalovirus infection in monkeys

Cody S. Nelson et al.

JCI INSIGHT (2017)

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Article Virology

Hemagglutinin Stalk Immunity Reduces Influenza Virus Replication and Transmission in Ferrets

Raffael Nachbagauer et al.

JOURNAL OF VIROLOGY (2016)

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Article Medicine, Research & Experimental

Understanding differences between synthetic and natural antibodies can help improve antibody engineering

Anat Burkovitz et al.

MABS (2016)

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Article Microbiology

In Vitro Characterization of Human Cytomegalovirus-Targeting Therapeutic Monoclonal Antibodies LJP538 and LJP539

Hetalkumar D. Patel et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2016)

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Article Biochemistry & Molecular Biology

Bispecific Anti-HIV-1 Antibodies with Enhanced Breadth and Potency

Stylianos Bournazos et al.

CELL (2016)

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Article Biochemistry & Molecular Biology

Structure and Function Analysis of an Antibody Recognizing All Influenza A Subtypes

Nicole L. Kallewaard et al.

CELL (2016)

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Review Immunology

Antibody-guided vaccine design: identification of protective epitopes

Antonio Lanzavecchia et al.

CURRENT OPINION IN IMMUNOLOGY (2016)

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Article Immunology

Complex Antigens Drive Permissive Clonal Selection in Germinal Centers

Masayuki Kuraoka et al.

IMMUNITY (2016)

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Article Immunology

Efficient Culture of Human Naive and Memory B Cells for Use as APCs

Kuei-Ying Su et al.

JOURNAL OF IMMUNOLOGY (2016)

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Article Multidisciplinary Sciences

Cryo-electron microscopy structure of a coronavirus spike glycoprotein trimer

Alexandra C. Walls et al.

NATURE (2016)

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Article Multidisciplinary Sciences

Pre-fusion structure of a human coronavirus spike protein

Robert N. Kirchdoerfer et al.

NATURE (2016)

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Review Biotechnology & Applied Microbiology

Envelope-specific antibodies and antibody-derived molecules for treating and curing HIV infection

Guido Ferrari et al.

NATURE REVIEWS DRUG DISCOVERY (2016)

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Article Biochemistry & Molecular Biology

Iterative structure-based improvement of a fusion-glycoprotein vaccine against RSV

M. Gordon Joyce et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2016)

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Article Multidisciplinary Sciences

Epitope specificity plays a critical role in regulating antibody-dependent cell-mediated cytotoxicity against influenza A virus

Wenqian He et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

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Article Multidisciplinary Sciences

A Trojan horse bispecific-antibody strategy for broad protection against ebolaviruses

Anna Z. Wec et al.

SCIENCE (2016)

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Article Multidisciplinary Sciences

Protective monotherapy against lethal Ebola virus infection by a potently neutralizing antibody

Davide Corti et al.

SCIENCE (2016)

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Article Multidisciplinary Sciences

Priming HIV-1 broadly neutralizing antibody precursors in human Ig loci transgenic mice

Devin Sok et al.

SCIENCE (2016)

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Article Multidisciplinary Sciences

HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogene

Joseph G. Jardine et al.

SCIENCE (2016)

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Article Multidisciplinary Sciences

Structural and molecular basis for Ebola virus neutralization by protective human antibodies

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Platelet-derived growth factor-α receptor is the cellular receptor for human cytomegalovirus gHgLgO trimer

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Structure-Based Design of Head-Only Fusion Glycoprotein Immunogens for Respiratory Syncytial Virus

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CURRENT OPINION IN CHEMICAL BIOLOGY (2015)

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Prefusion F-specific antibodies determine the magnitude of RSV neutralizing activity in human sera

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Crystal Structure of the Human Cytomegalovirus Glycoprotein B

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Production and stabilization of the trimeric influenza hemagglutinin stem domain for potentially broadly protective influenza vaccines

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A common solution to group 2 influenza virus neutralization

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Antibody-driven design of a human cytomegalovirus gHgLpUL128L subunit vaccine that selectively elicits potent neutralizing antibodies

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Mechanism for neutralizing activity by the anti-CMV gH/gL monoclonal antibody MSL-109

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Potent Neutralization of MERS-CoV by Human Neutralizing Monoclonal Antibodies to the Viral Spike Glycoprotein

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Receptor mimicry by antibody F045-092 facilitates universal binding to the H3 subtype of influenza virus

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Efficient Methods To Isolate Human Monoclonal Antibodies from Memory B Cells and Plasma Cells

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MICROBIOLOGY SPECTRUM (2014)

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An In Vivo Human-Plasmablast Enrichment Technique Allows Rapid Identification of Therapeutic Influenza A Antibodies

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Hemagglutinin Stalk-Based Universal Vaccine Constructs Protect against Group 2 Influenza A Viruses

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Chimeric Hemagglutinin Influenza Virus Vaccine Constructs Elicit Broadly Protective Stalk-Specific Antibodies

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Antibodies are necessary for rVSV/ZEBOV-GP-mediated protection against lethal Ebola virus challenge in nonhuman primates

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Structure-Based Design of a Fusion Glycoprotein Vaccine for Respiratory Syncytial Virus

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Human Cytomegalovirus (HCMV) Glycoprotein gB Promotes Virus Entry In Trans Acting as the Viral Fusion Protein Rather than as a Receptor-Binding Protein

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Broadly Neutralizing Antibody PGT121 Allosterically Modulates CD4 Binding via Recognition of the HIV-1 gp120 V3 Base and Multiple Surrounding Glycans

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IgG subclass profiles in normal human sera of antibodies specific to five kinds of microbial antigens

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Structure of an Antibody in Complex with Its Mucin Domain Linear Epitope That Is Protective against Ebola Virus

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Influenza Viruses Expressing Chimeric Hemagglutinins: Globular Head and Stalk Domains Derived from Different Subtypes

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Human broadly neutralizing antibodies to the envelope glycoprotein complex of hepatitis C virus

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Neutralizing antibodies against the preactive form of respiratory syncytial virus fusion protein offer unique possibilities for clinical intervention

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Highly potent HIV-specific antibody neutralization in vitro translates into effective protection against mucosal SHIV challenge in vivo

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Heterosubtypic antibody recognition of the influenza virus hemagglutinin receptor binding site enhanced by avidity

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Computation-Guided Backbone Grafting of a Discontinuous Motif onto a Protein Scaffold

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A Neutralizing Antibody Selected from Plasma Cells That Binds to Group 1 and Group 2 Influenza A Hemagglutinins

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A Highly Conserved Neutralizing Epitope on Group 2 Influenza A Viruses

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SCIENCE (2011)

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The Human Immune Response to Dengue Virus Is Dominated by Highly Cross-Reactive Antibodies Endowed with Neutralizing and Enhancing Activity

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Correlates of Protection Induced by Vaccination

Stanley A. Plotkin

CLINICAL AND VACCINE IMMUNOLOGY (2010)

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Isolation of Human Monoclonal Antibodies That Potently Neutralize Human Cytomegalovirus Infection by Targeting Different Epitopes on the gH/gL/UL128-131A Complex

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Respiratory Syncytial Virus-Neutralizing Monoclonal Antibodies Motavizumab and Palivizumab Inhibit Fusion

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Generation of stable monoclonal antibody-producing B cell receptor-positive human memory B cells by genetic programming

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Structural basis of respiratory syncytial virus neutralization by motavizumab

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Design of an HA2-based Escherichia coli expressed influenza immunogen that protects mice from pathogenic challenge

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Elicitation of structure-specific antibodies by epitope scaffolds

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Cross-Reacting Antibodies Enhance Dengue Virus Infection in Humans

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Rational Design of Envelope Identifies Broadly Neutralizing Human Monoclonal Antibodies to HIV-1

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Computational Design of Epitope-Scaffolds Allows Induction of Antibodies Specific for a Poorly Immunogenic HIV Vaccine Epitope

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Engineering human hematopoietic stem/progenitor cells to produce a broadly neutralizing anti-HIV antibody after in vitro maturation to human B lymphocytes

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Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals

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Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses

Jianhua Sui et al.

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NEW ENGLAND JOURNAL OF MEDICINE (2009)

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Glycans on influenza hemagglutinin affect receptor binding and immune response

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Structural characterization of a human Fc fragment engineered for lack of effector functions

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ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2008)

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Monitoring human cytomegalovirus infection in transplant recipients

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Computational characterization of B-cell epitopes

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Structure of the Ebola virus glycoprotein bound to an antibody from a human survivor

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Heterosubtypic Neutralizing Monoclonal Antibodies Cross-Protective against H5N1 and H1N1 Recovered from Human IgM+ Memory B Cells

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Properties of human IgG1s engineered for enhanced binding to the neonatal Fc receptor (FcRn)

William F. Dall'Acqua et al.

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Human cytomegalovirus virion protein complex required for epithelial and endothelial cell tropism

D Wang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

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Monoclonal antibodies to SARS-associated coronavirus (SARS-CoV): Identification of neutralizing and antibodies reactive to S, N, M and E viral proteins

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Live attenuated recombinant vaccine protects nonhuman primates against Ebola and Marburg viruses

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HEALTH AFFAIRS (2005)

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Stochastic pairing of Ig heavy and light chains frequently generates B cell antigen receptors that are subject to editing in vivo

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INTERNATIONAL IMMUNOLOGY (2005)

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A high-affinity monoclonal antibody to anthrax protective antigen passively protects rabbits before and after aerosolized Bacillus anthracis spore challenge

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INFECTION AND IMMUNITY (2005)

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NATURE REVIEWS MICROBIOLOGY (2004)

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An efficient method to make human monoclonal antibodies from memory B cells: potent neutralization of SARS coronavirus

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Transmission of the severe acute respiratory syndrome on aircraft

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Reverse genetics with a full-length infectious cDNA of severe acute respiratory syndrome coronavirus

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

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Immunofocusing: antigen engineering to promote the induction of HIV-neutralizing antibodies

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TRENDS IN MOLECULAR MEDICINE (2003)

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Dengue hemorrhagic fever in infants: Research opportunities ignored

SB Halstead et al.

EMERGING INFECTIOUS DISEASES (2002)

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Protection against anthrax toxin by recombinant antibody fragments correlates with antigen affinity

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HIV and cytomegalovirus viral load and clinical outcomes in AIDS and cytomegalovirus retinitis patients: Monoclonal Antibody Cytomegalovirus Retinitis Trial

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