期刊
NATURE NEUROSCIENCE
卷 25, 期 7, 页码 924-+出版社
NATURE PORTFOLIO
DOI: 10.1038/s41593-022-01106-5
关键词
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资金
- Wyss Center [WCP 008]
- GTX Medicals
- Bertarelli Foundation
- Swiss National Science Foundation Ambizione Fellowship [167912]
- Swiss National Science Foundation Doc-Mobility Grant [188027]
- European Union [665667]
- Swiss National Foundation [BSCGI0_157800]
- Whitaker International Scholars Program fellowship
- University of Fribourg
- Swiss National Science Foundation (SNF) [BSCGI0_157800] Funding Source: Swiss National Science Foundation (SNF)
This study focuses on restoring arm and hand control in paralyzed individuals using spinal cord stimulation. By stimulating specific spinal segments, sustained arm movements were produced, allowing monkeys with paralysis to regain the ability to reach and grasp within a few days after injury.
Regaining arm control is a top priority for people with paralysis. Unfortunately, the complexity of the neural mechanisms underlying arm control has limited the effectiveness of neurotechnology approaches. Here, we exploited the neural function of surviving spinal circuits to restore voluntary arm and hand control in three monkeys with spinal cord injury, using spinal cord stimulation. Our neural interface leverages the functional organization of the dorsal roots to convey artificial excitation via electrical stimulation to relevant spinal segments at appropriate movement phases. Stimulation bursts targeting specific spinal segments produced sustained arm movements, enabling monkeys with arm paralysis to perform an unconstrained reach-and-grasp task. Stimulation specifically improved strength, task performances and movement quality. Electrophysiology suggested that residual descending inputs were necessary to produce coordinated movements. The efficacy and reliability of our approach hold realistic promises of clinical translation. This paper describes a neurotechnology that interacts with neural circuits in the spinal cord to restore arm and hand control after injury. With this implant, monkeys with paralysis recovered the ability to reach and grasp just a few days after injury.
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