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Article
Medicine, General & Internal
Shamil Haroon et al.
Summary: This study aims to evaluate the symptom burden and underlying pathophysiology of Long COVID syndromes in non-hospitalised individuals and evaluate potential therapies.
Article
Medicine, General & Internal
Sarah E. Hughes et al.
Summary: This study described the development and validation of a novel patient reported outcome measure for symptom burden from long covid, called the Symptom Burden Questionnaire for Long Covid (SBQ-LC). The questionnaire consists of 17 independent scales and has promising psychometric properties. It can be used to evaluate the impact of interventions and inform best practices in clinical management.
BMJ-BRITISH MEDICAL JOURNAL
(2022)
Article
Infectious Diseases
Claudia Carvalho-Schneider et al.
Summary: In noncritical COVID-19 patients, most individuals continued to experience symptoms up to 2 months after symptom onset, with the main complaints being anosmia/ageusia, dyspnoea, or asthenia. Factors associated with persistent symptoms included age 40-60 years old, hospital admission, and abnormal auscultation at symptom onset.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Public, Environmental & Occupational Health
Krishna Margadhamane Gokhale et al.
Summary: The paper introduces a new software program DExtER that aids in the extraction and processing of primary care electronic health records for high quality epidemiological studies. The tool, with a user-friendly interface, offers the ability to obtain data extracts specific to each research question and study design.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Medicine, General & Internal
Chaolin Huang et al.
Summary: This study aimed to investigate the long-term health consequences of discharged COVID-19 patients and associated risk factors, particularly disease severity. Patients with more severe illness during hospitalization showed more severe impaired pulmonary diffusion capacities and abnormal chest imaging manifestations, highlighting the need for targeted interventions for long-term recovery.
Editorial Material
Medicine, General & Internal
Kabir Yadav et al.
Summary: This article explains immortal time bias, which is an error that can occur when estimating the association between exposure and outcome, and presents approaches to minimize or avoid this bias.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Biochemistry & Molecular Biology
Carole H. Sudre et al.
Summary: Reports on long-lasting COVID-19 symptoms, known as 'long COVID', are increasing. Analysis of data from over 4,000 COVID-19 cases revealed that long COVID is more common in older individuals, those with higher body mass index, and females. Experiencing more than five symptoms in the first week of illness was associated with long COVID. A simple model showed promise in distinguishing between short and long COVID cases early in the disease.
Article
Medicine, General & Internal
Hannah R. Whittaker et al.
Summary: The study described the rates for consulting a general practitioner for sequelae after acute covid-19 infection in patients admitted to hospital and those managed in the community. It found differences in sequelae rates between these two groups, with some sequelae decreasing over time while others, such as anxiety and depression, persisted in the community. Rates of some outcomes decreased after vaccination for covid-19.
BMJ-BRITISH MEDICAL JOURNAL
(2021)
Article
Medicine, General & Internal
Maxime Taquet et al.
Summary: This study investigated the incidence and co-occurrence of long-COVID features in COVID-19 survivors, with comparisons to influenza patients, using electronic health records data. The findings showed that long-COVID clinical features were more commonly reported after COVID-19 infection, and differences were associated with sex, age, and illness severity.
Review
Medicine, General & Internal
Destin Groff et al.
Summary: This systematic review found that more than half of COVID-19 survivors experienced PASC 6 months after recovery, with the most common effects being functional mobility impairments, pulmonary abnormalities, and mental health disorders.
Article
Multidisciplinary Sciences
Ziyad Al-Aly et al.
Summary: This study comprehensively describes the post-acute sequelae of COVID-19 using national healthcare databases, finding increased risk of death and use of health resources beyond the first 30 days of illness, as well as incident sequelae in various organ systems, increased use of therapeutic agents, and evidence of laboratory abnormalities. The findings show a risk gradient according to the severity of acute COVID-19 infection and highlight the burden of health loss experienced by patients who survive the acute phase.
Review
Biochemistry & Molecular Biology
Ani Nalbandian et al.
Summary: SARS-CoV-2 is responsible for the COVID-19 pandemic, causing global healthcare crises. Recovery from COVID-19 may lead to persistent symptoms and long-term complications, prompting the need for multidisciplinary care and follow-up for survivors.
Review
Rheumatology
Manuel Ramos-Casals et al.
Summary: Immune-related disorders in patients with COVID-19 present with diverse manifestations mimicking various inflammatory and autoimmune diseases, with clinical phenotype influenced by factors like age, sex, and ethnicity. The severity of symptoms varies greatly, from benign to life-threatening, and the pathogenesis and optimal therapy for these manifestations require further research.
NATURE REVIEWS RHEUMATOLOGY
(2021)
Article
Medicine, General & Internal
Angela Wood et al.
Summary: This study describes a novel England-wide electronic health record (EHR) resource for whole population research on covid-19 and cardiovascular disease, highlighting the importance of linking person level data across health settings to maximize completeness of key characteristics and to ascertain cardiovascular events and covid-19 diagnoses.
BMJ-BRITISH MEDICAL JOURNAL
(2021)
Review
Medicine, General & Internal
Olalekan Lee Aiyegbusi et al.
Summary: Patients with long COVID experience a wide range of physical and mental symptoms, with common issues including fatigue, shortness of breath, and headaches. Beyond symptoms and complications, they often report impaired quality of life, mental health issues, and employment problems.
JOURNAL OF THE ROYAL SOCIETY OF MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Bjorn Blomberg et al.
Summary: An analysis of patients with SARS-CoV-2 infections in Bergen, Norway, revealed that a high proportion of patients experienced long-term COVID symptoms at 6 months, even though they were relatively young and had only mild to moderate acute COVID-19 symptoms. This highlights the significance of infection control measures, such as vaccination.
Article
Multidisciplinary Sciences
Sandra Lopez-Leon et al.
Summary: This study aimed to identify studies assessing the long-term effects of COVID-19, estimating that 80% of infected patients will develop one or more long-term symptoms, with the most common being fatigue, headache, attention disorder, hair loss, and dyspnea.
SCIENTIFIC REPORTS
(2021)
Review
Public, Environmental & Occupational Health
Melina Michelen et al.
Summary: Long COVID is a complex condition with prolonged and heterogeneous symptoms, including weakness, general malaise, fatigue, concentration impairment, and breathlessness. Approximately 37% of patients reported reduced quality of life, and 26% of studies presented evidence of reduced pulmonary function. There is an urgent need for further studies to explore the etiology, risk factors, and biomarkers of long COVID in different populations and settings.
Article
Medicine, General & Internal
Hannah E. Davis et al.
Summary: Patients with Long COVID report prolonged, multisystem involvement and significant disability. By seven months, many patients have not yet recovered (mainly from systemic and neurological/cognitive symptoms), have not returned to previous levels of work, and continue to experience significant symptom burden.
Article
Respiratory System
Islam Galal et al.
Summary: This study evaluated the frequency, patterns, and determinants of persistent post-COVID-19 symptoms, finding that the need for oxygen therapy, pre-existing hypertension, chronic pulmonary disorders, and any chronic comorbidity were the main determinants of persistent symptoms. The severity of acute phase symptoms and a COVID-19 symptom score >18, along with the presence of any comorbid diseases, increased the risk for persistent post-COVID-19 manifestations and severity.
EGYPTIAN JOURNAL OF BRONCHOLOGY
(2021)
Editorial Material
Medicine, General & Internal
Carlos del Rio et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2020)
Article
Health Care Sciences & Services
Emma Ladds et al.
BMC HEALTH SERVICES RESEARCH
(2020)
Article
Multidisciplinary Sciences
Laurie G. Jacobs et al.
Article
Psychology, Multidisciplinary
Bridget E. Weller et al.
JOURNAL OF BLACK PSYCHOLOGY
(2020)
Article
Public, Environmental & Occupational Health
Achim Wolf et al.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2019)
Article
Medicine, General & Internal
Sarah J. Price et al.
Article
Mathematics, Interdisciplinary Applications
Karen L. Nylund et al.
STRUCTURAL EQUATION MODELING-A MULTIDISCIPLINARY JOURNAL
(2007)
