Making nucleic acid monomers

Amino-containing four-carbon threose nucleic acids (TNAs) have long been considered to be prebiotically irrelevant due to their difficult formation. Now, a prebiotically plausible route to 3'-amino-TNA nucleoside triphosphate has been developed, raising the possibility of 3'-amino-TNA as a non-canonical nucleic acid during the origin of life.

Automated summary

Amino-containing four-carbon threose nucleic acids (TNAs) have long been considered irrelevant to prebiotic chemistry due to their challenging formation process. However, a new prebiotically plausible method for synthesizing 3'-amino-TNA nucleoside triphosphate has been developed, suggesting the potential role of 3'-amino-TNA as a non-canonical nucleic acid in the origin of life.