Shackled ribosomes unleashed

A directed evolution approach delivers ribosomes with highly functional tethered subunits. Combining the decoding and peptidyl transferase activities of the ribosome into a single entity sets the scene for more efficient protein engineering technologies.

Automated summary

A directed evolution approach can generate ribosomes with highly functional tethered subunits, integrating the decoding and peptidyl transferase activities of the ribosome into a single entity, potentially leading to more efficient protein engineering technologies.