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Voyage to minimal base editors

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NATURE CHEMICAL BIOLOGY
卷 18, 期 9, 页码 920-921

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NATURE PORTFOLIO
DOI: 10.1038/s41589-022-01101-8

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A TnpB-based adenine base editor has been developed and can be loaded into a single AAV vector without compromising editing activity, showing potential for efficient gene editing.
Transposon-associated transposase B (TnpB) is the putative ancestor of Cas nucleases. A TnpB-based adenine base editor has now been developed that is small enough to be loaded into a single AAV vector without compromising editing activity.

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