EGFR ligands dictate tumour suppression

EGFR is an oncogene that is frequently amplified in glioblastoma. A new study suggests a tumour-suppressive role of EGFR in EGFR-amplified glioblastoma regulated by ligand abundance. Increased EGFR ligand in EGFR-amplified glioblastoma suppresses invasion by upregulating BIN3 and inhibiting activation of Rho GTPases.

Automated summary

EGFR plays a tumour-suppressive role in EGFR-amplified glioblastoma, regulated by ligand abundance. Increased EGFR ligand suppresses invasion by upregulating BIN3 and inhibiting activation of Rho GTPases.