☆ 4.8 Review

Untangling the web of intratumour heterogeneity

NATURE CELL BIOLOGY (2022)

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Article Multidisciplinary Sciences

Non-genetic determinants of malignant clonal fitness at single-cell resolution

Katie A. Fennell et al.

Summary: Studies have shown that malignant clonal dominance is a cell-intrinsic and heritable property facilitated by the repression of antigen presentation and increased expression of the secretory leukocyte peptidase inhibitor gene (Slpi). Increased transcriptional heterogeneity enables clonal fitness in diverse tissues and immune microenvironments, as well as in the context of clonal competition between genetically distinct clones. Leukemia stem cells (LSCs) display heritable clone-intrinsic properties of high and low clonal output, which contribute to the overall tumor mass.

NATURE (2022)

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Article Oncology

Smarca4 Inactivation Promotes Lineage- Specific Transformation and Early Metastatic Features in the Lung

Carla P. Concepcion et al.

Summary: The loss of Smarca4 results in increased sensitivity to malignant transformation and tumor progression in lung cells, leading to advanced dedifferentiated tumors and higher metastatic incidence. Smarca4-deficient tumors lack lung lineage transcription factor activities and resemble a metastatic cell state, suggesting a critical role of Smarca4 in regulating cellular transformation and metastasis during lung cancer evolution.

CANCER DISCOVERY (2022)

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Article Oncology

MYC Levels Regulate Metastatic Heterogeneity in Pancreatic Adenocarcinoma

Ravikanth Maddipati et al.

Summary: This study investigated the biological and functional differences driving metastasis in patients with PDAC using a mouse model. The findings revealed an association between the extent of metastasis and gene amplification or transcriptional upregulation of the MYC gene and its downstream targets. Functional experiments demonstrated that MYC promotes metastasis by recruiting tumor-associated macrophages. Further analysis showed that metastatic progression in human PDAC is associated with activation of MYC signaling pathways and MYC amplifications in metastatic patients specifically.

CANCER DISCOVERY (2022)

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Article Oncology

A human breast cancer-derived xenograft and organoid platform for drug discovery and precision oncology

Katrin P. Guillen et al.

Summary: Models that recapitulate the complexity of human tumors are urgently needed to develop more effective cancer therapies. In this study, researchers report a bank of human patient-derived xenografts and organoid cultures from breast cancers that are resistant to treatment and have metastasized. They demonstrate the feasibility and cost-effectiveness of using these models for drug screening, and also show the potential of applying precision oncology in real-time clinical care. The study provides valuable methods and resources for functional precision medicine and drug development for human breast cancer.

NATURE CANCER (2022)

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Review Genetics & Heredity

Integrating genetic and non-genetic determinants of cancer evolution by single-cell multi-omics

Anna S. Nam et al.

Summary: Cancer is an evolutionary process involving genetic and non-genetic factors, with intratumoural heterogeneity playing a key role in cancer evolution. Single-cell multi-omics technologies are essential for capturing and integrating the different layers of heritable information to study cancer evolution effectively.

NATURE REVIEWS GENETICS (2021)

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Article Biochemistry & Molecular Biology

Single-cell dissection of intratumoral heterogeneity and lineage diversity in metastatic gastric adenocarcinoma

Ruiping Wang et al.

Summary: The study investigated intratumoral heterogeneity (ITH) in peritoneal carcinomatosis of gastric cancer patients through single-cell transcriptome profiling, revealing significant correlations between ITH and patient survival. By analyzing the diversity in tumor cell lineage/state compositions, researchers identified a prognostic signature that could be practical for patient stratification.

NATURE MEDICINE (2021)

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Article Multidisciplinary Sciences

Single-cell lineages reveal the rates, routes, and drivers of metastasis in cancer xenografts

Jeffrey J. Quinn et al.

Summary: This study used a Cas9-based lineage tracer to track the development and metastasis of lung cancer cells in a mouse model over months, revealing heterogeneity in metastatic capacity and genetic differences that drive invasiveness. The study also uncovered some genes driving metastasis and an unexpected suppressive role of KRT17 in metastasis.

SCIENCE (2021)

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Review Chemistry, Medicinal

Targeting MYC: From understanding its biology to drug discovery

Julie Ross et al.

Summary: The MYC oncogene is a high priority target for clinical intervention in cancer patients, with direct small molecule inhibition traditionally facing challenges due to its intrinsically disordered nature. However, recent strategies for indirectly targeting MYC, such as MYC guanine quadruplex stabilization and disruption of MYC:MAX heterodimer, have emerged with the advancement of protein structural information and computational tools in medicinal chemistry.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)

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Article Biochemical Research Methods

Joint single-cell measurements of nuclear proteins and RNA in vivo

Hattie Chung et al.

Summary: This study introduces a new method called inCITE-seq, which can measure intranuclear protein levels and the transcriptome in single nuclei simultaneously. By applying this technology to mouse brain tissue, researchers were able to analyze the relationship between quantitative protein levels of transcription factors (TFs) and gene expression programs. The results showed that inCITE-seq can provide insights into how nuclear proteins shape gene expression in native tissue contexts.

NATURE METHODS (2021)

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Article Biochemical Research Methods

Joint profiling of histone modifications and transcriptome in single cells from mouse brain

Chenxu Zhu et al.

Summary: Genome-wide profiling of histone modifications can provide insights into regulatory elements, cell-type-specific gene expression, and epigenetic regulatory mechanisms. An ultra-high-throughput method, Paired-Tag, allows joint profiling of histone modifications and transcriptome at single-cell resolution. Integrative analysis of the data reveals distinct groups of genes subject to divergent epigenetic regulatory mechanisms.

NATURE METHODS (2021)

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Article Multidisciplinary Sciences

Malignant subclone drives metastasis of genetically and phenotypically heterogenous cell clusters through fibrotic niche generation

Sau Yee Kok et al.

Summary: In the liver, malignant subclones induce fibrotic niche generation through hepatic stellate cell activation, supporting the survival and colonization of non-metastatic cells to develop polyclonal metastasis.

NATURE COMMUNICATIONS (2021)

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Article Multidisciplinary Sciences

Subclone-specific microenvironmental impact and drug response in refractory multiple myeloma revealed by single-cell transcriptomics

Stephan M. Tirier et al.

Summary: Relapsed/refractory multiple myeloma (RRMM) is characterized by a remarkable heterogeneity and high drug resistance. Here, the authors analyse RRMM samples by single-cell RNA-sequencing, revealing molecular features associated with high-risk chromosomal 1q-gain and changes in the tumor microenvironment.

NATURE COMMUNICATIONS (2021)

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Article Multidisciplinary Sciences

Subtype heterogeneity and epigenetic convergence in neuroendocrine prostate cancer

Paloma Cejas et al.

Summary: Neuroendocrine carcinomas (NECs) arise from different anatomic sites, but share similar histological and clinical features. The epigenetic landscape of NECs converges towards a common state, while distinct subtypes occur within neuroendocrine prostate cancer, contributing to intratumor heterogeneity in clinical samples.

NATURE COMMUNICATIONS (2021)

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Article Biology

Bisulfite-free epigenomics and genomics of single cells through methylation-sensitive restriction

Christoph Niemoeller et al.

Summary: The study introduces a novel method, epi-gSCAR, for analyzing DNA methylation and genetic variants in single cells, allowing for accurate and reproducible measurements at the single cell level, and enabling differentiation between cell lines based on their DNA methylation and genetic profiles.

COMMUNICATIONS BIOLOGY (2021)

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Article Oncology

Impact of HER2 Heterogeneity on Treatment Response of Early-Stage HER2-Positive Breast Cancer: Phase II Neoadjuvant Clinical Trial of T-DM1 Combined with Pertuzumab

Otto Metzger Filho et al.

Summary: Intratumor heterogeneity, particularly the fraction of ERBB2 nonamplified cancer cells, is strongly correlated with resistance to HER2-targeted therapies and could potentially aid in optimizing treatment selection for HER2-positive breast cancer patients.

CANCER DISCOVERY (2021)

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Article Biology

Simultaneous trimodal single-cell measurement of transcripts, epitopes, and chromatin accessibility using TEA-seq

Elliott Swanson et al.

Summary: Single-cell measurements play a key role in understanding diverse pathways of differentiation, cellular responses to signals, and human diseases. Through innovative technologies, a novel assay has been developed that allows simultaneous measurement of cell surface markers and chromatin accessibility, providing a new toolkit to identify type-specific gene regulation and expression.

ELIFE (2021)

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Article Multidisciplinary Sciences

XYZeq: Spatially resolved single-cell RNA sequencing reveals expression heterogeneity in the tumor microenvironment

Youjin Lee et al.

Summary: Using the XYZeq workflow, spatial metadata can be encoded into scRNAseq libraries to analyze the transcriptome and spatial localization of individual cells, revealing the functional interactions within an anatomical space. Studies show that tumor-associated MSCs express different tumor suppressor genes at varying distances from the tumor core, highlighting the spatial distribution and functional characteristics of cells in pathological tissues.

SCIENCE ADVANCES (2021)

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Article Oncology

Single-cell lineage tracing of metastatic cancer reveals selection of hybrid EMT states

Kamen P. Simeonov et al.

Summary: This study introduces a new inducible CRISPR-Cas9-based lineage recorder, macsGESTALT, and reveals that the metastatic potential of cells peaks in rare, late-hybrid EMT states, which are relevant to clinical disease progression.

CANCER CELL (2021)

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Article Cell Biology

Cooperation between melanoma cell states promotes metastasis through heterotypic cluster formation

Nathaniel R. Campbell et al.

Summary: Melanomas can have multiple coexisting cell states, including proliferative (PRO) versus invasive (INV) subpopulations that cooperate in the seeding of metastasis. INV cells tightly adhere to each other and form clusters with a rim of PRO cells, facilitating dissemination of less metastatic PRO cells. TFAP2 neural crest transcription factor is identified as a master regulator of clustering and PRO/INV states.

DEVELOPMENTAL CELL (2021)

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Review Biochemistry & Molecular Biology

Cancer evolution: Darwin and beyond

Roberto Vendramin et al.

Summary: Cancer evolution is not solely explained by the Darwinian model, but also involves factors such as macroevolutionary events, neutral evolution, and even the aging of somatic cells. These elements collectively form a model of cancer evolution that extends beyond Darwin.

EMBO JOURNAL (2021)

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Review Immunology

A bird's eye view of fibroblast heterogeneity: A pan-disease, pan-cancer perspective

Rachana N. Pradhan et al.

Summary: The article reviews recent advances in single-cell technologies for understanding fibroblast heterogeneity across tissues, emphasizing the importance of this understanding in cancer and fibrosis therapy. Integrating single-cell studies can help identify common fibroblast phenotypes across disease states, facilitating drug discovery and targeting research.

IMMUNOLOGICAL REVIEWS (2021)

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Article Multidisciplinary Sciences

Cycling cancer persister cells arise from lineages with distinct programs

Yaara Oren et al.

Summary: Recent studies have revealed that cancer cells can enter different lineages in response to treatment, with distinct biological characteristics and metabolic programs. Proliferative capacity of drug-tolerant persister cells is associated with upregulation of antioxidant gene programs and a metabolic shift to fatty acid oxidation.

NATURE (2021)

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Article Biotechnology & Applied Microbiology

Scalable, multimodal profiling of chromatin accessibility, gene expression and protein levels in single cells

Eleni P. Mimitou et al.

Summary: ASAP-seq is a new tool that can simultaneously profile chromatin accessibility and protein levels in single cells. It uses a bridging approach that repurposes antibody:oligonucleotide conjugates originally designed for protein measurements paired with single-cell RNA sequencing. Together with DOGMA-seq, it demonstrates the utility of systematic multi-omic profiling by revealing coordinated and distinct changes in chromatin, RNA, and surface proteins in single cells.

NATURE BIOTECHNOLOGY (2021)

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Article Genetics & Heredity

A single-cell and spatially resolved atlas of human breast cancers

Sunny Z. Wu et al.

Summary: This study presents a comprehensive transcriptional atlas of the cellular architecture of breast cancer, identifying recurrent neoplastic cell heterogeneity and new immune cell populations associated with clinical outcomes. A multi-omic atlas integrates single-cell RNA sequencing, spatial transcriptomics, and immunophenotyping to stratify breast cancer into nine ecotypes with unique cellular compositions and clinical outcomes.

NATURE GENETICS (2021)

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Article Multidisciplinary Sciences

Developmental chromatin programs determine oncogenic competence in melanoma

Arianna Baggiolini et al.

Summary: The intrinsic transcriptional program present in the cell of origin plays a key role in the transforming ability of oncogenes like BRAF(V600E), with developmental chromatin factors mediating oncogenic competence and allowing for proper response to oncogenes.

SCIENCE (2021)

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Article Multidisciplinary Sciences

Single-cell RNA sequencing shows the immunosuppressive landscape and tumor heterogeneity of HBV-associated hepatocellular carcinoma

Daniel Wai-Hung Ho et al.

Summary: The interaction between tumor cells and immune cells in the tumor microenvironment plays a crucial role in tumor immunity, as evidenced by single-cell RNA sequencing analysis in HBV-associated human hepatocellular carcinoma patients. This study reveals the immunosuppressive landscape and intercellular interactions, providing mechanistic insights for the development of effective immune-oncology treatments in hepatocellular carcinoma.

NATURE COMMUNICATIONS (2021)

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Article Multidisciplinary Sciences

Chromosomal copy number heterogeneity predicts survival rates across cancers

Erik van Dijk et al.

Summary: Intratumour heterogeneity (ITH) is associated with worse prognosis in cancer, and efficient frameworks to measure it are needed. Here the authors develop a method to estimate copy number heterogeneity, and propose that it is driven by chromosomal instability and can predict pan-cancer survival.

NATURE COMMUNICATIONS (2021)

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Article Multidisciplinary Sciences

Dissecting spatial heterogeneity and the immune-evasion mechanism of CTCs by single-cell RNA-seq in hepatocellular carcinoma

Yun-Fan Sun et al.

Summary: This study used single-cell RNA sequencing to analyze circulating tumor cells from liver cancer patients, revealing that the transcriptional dynamics of CTCs are associated with stress response, cell cycle, and immune evasion signaling. Additionally, it was identified that CCL5 plays a crucial role in immune evasion of CTCs.

NATURE COMMUNICATIONS (2021)

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Article Multidisciplinary Sciences

Comprehensive characterization of 536 patient-derived xenograft models prioritizes candidatesfor targeted treatment

Hua Sun et al.

Summary: This study presents genomic landscapes of 536 patient-derived xenograft (PDX) models across 25 cancer types, providing insights into their molecular features and suitability for clinical trials. PDXs typically have higher purity than human tumors and are useful for investigating dynamic driver events and molecular properties, making them valuable tools in cancer research and drug development.

NATURE COMMUNICATIONS (2021)

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Article Multidisciplinary Sciences

The site of breast cancer metastases dictates their clonal composition and reversible transcriptomic profile

Jean Berthelet et al.

Summary: The study optimized the use of optical barcoding to visualize and characterize cancer subclones, revealing that lung metastases were highly polyclonal while liver metastases were not. The transcriptome of the subclones varied according to their metastatic niche, indicating that the heterogeneity observed in metastases is largely dictated by the tumor microenvironment.

SCIENCE ADVANCES (2021)

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Article Oncology

Multifunctional barcoding with ClonMapper enables high-resolution study of clonal dynamics during tumor evolution and treatment

Catherine Gutierrez et al.

Summary: ClonMapper is a multifunctional tool developed by Wu and colleagues, which combines DNA barcoding, single-cell RNA sequencing, and clonal isolation to study complex clonal dynamics in tumor progression and therapeutic response.

NATURE CANCER (2021)

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Article Hematology

Therapy-induced mutations drive the genomic landscape of relapsed acute lymphoblastic leukemia

Benshang Li et al.

BLOOD (2020)

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Review Oncology

Cancer as a disease of old age: changing mutational and microenvironmental landscapes

Ezio Laconi et al.

BRITISH JOURNAL OF CANCER (2020)

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Article Biochemistry & Molecular Biology

A Patient-Derived Glioblastoma Organoid Model and Biobank Recapitulates Inter- and Intra-tumoral Heterogeneity

Fadi Jacob et al.

CELL (2020)

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Article Biotechnology & Applied Microbiology

Integrating microarray-based spatial transcriptomics and single-cell RNA-seq reveals tissue architecture in pancreatic ductal adenocarcinomas

Reuben Moncada et al.

NATURE BIOTECHNOLOGY (2020)

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Article Cell Biology

HSF1 phase transition mediates stress adaptation and cell fate decisions

Giorgio Gaglia et al.

NATURE CELL BIOLOGY (2020)

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Article Multidisciplinary Sciences

Cancer-associated fibroblast heterogeneity in axillary lymph nodes drives metastases in breast cancer through complementary mechanisms

Floriane Pelon et al.

NATURE COMMUNICATIONS (2020)

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Article Oncology

Oncogenic KRAS-Driven Metabolic Reprogramming in Pancreatic Cancer Cells Utilizes Cytokines from the Tumor Microenvironment

Prasenjit Dey et al.

CANCER DISCOVERY (2020)

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Review Biochemistry & Molecular Biology

Fibrosis and cancer: A strained relationship

Bram Piersma et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2020)

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Review Oncology

Advancing Cancer Research and Medicine with Single-Cell Genomics

Bora Lim et al.

CANCER CELL (2020)

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Article Pathology

SMARCA family of genes

Runjan Chetty et al.

JOURNAL OF CLINICAL PATHOLOGY (2020)

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Article Multidisciplinary Sciences

An organoid biobank for childhood kidney cancers that captures disease and tissue heterogeneity

Camilla Calandrini et al.

NATURE COMMUNICATIONS (2020)

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Article Biotechnology & Applied Microbiology

pHLuc, a Ratiometric Luminescent Reporter for in vivo Monitoring of Tumor Acidosis

Tiffany T. Ong et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2020)

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Article Biochemistry & Molecular Biology

Parallel bimodal single-cell sequencing of transcriptome and chromatin accessibility

Qiao Rui Xing et al.

GENOME RESEARCH (2020)

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Article Oncology

Emergence of a High-Plasticity Cell State during Lung Cancer Evolution

Nemanja Despot Marjanovic et al.

CANCER CELL (2020)

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Article Cell Biology

Dissecting intratumour heterogeneity of nodal B-cell lymphomas at the transcriptional, genetic and drug-response levels

Tobias Roider et al.

NATURE CELL BIOLOGY (2020)

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Article Genetics & Heredity

Single-cell analysis of clonal maintenance of transcriptional and epigenetic states in cancer cells

Zohar Meir et al.

NATURE GENETICS (2020)

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A programmable sequence of reporters for lineage analysis

Jorge Garcia-Marques et al.

NATURE NEUROSCIENCE (2020)

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A versatile system to record cell-cell interactions

Rui Tang et al.

ELIFE (2020)

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Article Biochemistry & Molecular Biology

The Stress-Like Cancer Cell State Is a Consistent Component of Tumorigenesis

Maayan Baron et al.

CELL SYSTEMS (2020)

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Review Cell Biology

Cell Competition Boosts Clonal Evolution and Hypoxic Selection in Cancer

Esha Madan et al.

TRENDS IN CELL BIOLOGY (2020)

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Article Cell Biology

Aging-Associated Alterations in Mammary Epithelia and Stroma Revealed by Single-Cell RNA Sequencing

Carman Man-Chung Li et al.

CELL REPORTS (2020)

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Article Oncology

A biobank of small cell lung cancer CDX models elucidates inter- and intratumoral phenotypic heterogeneity

Kathryn L. Simpson et al.

NATURE CANCER (2020)

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Article Oncology

Impact of extracellular matrix stiffness on genomic heterogeneity in MYCN-amplified neuroblastoma cell line

Amparo Lopez-Carrasco et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2020)

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Review Oncology

Non-genetic mechanisms of therapeutic resistance in cancer

Jean-Christophe Marine et al.

NATURE REVIEWS CANCER (2020)

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Review Immunology

A guide to cancer immunotherapy: from T cell basic science to clinical practice

Alex D. Waldman et al.

NATURE REVIEWS IMMUNOLOGY (2020)

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Review Oncology

Applications of organoids for cancer biology and precision medicine

Yuan-Hung Lo et al.

NATURE CANCER (2020)

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Article Oncology

A deep learning image-based intrinsic molecular subtype classifier of breast tumors reveals tumor heterogeneity that may affect survival

Mustafa I. Jaber et al.

BREAST CANCER RESEARCH (2020)

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Article Multidisciplinary Sciences

Neutrophils escort circulating tumour cells to enable cell cycle progression

Barbara Maria Szczerba et al.

NATURE (2019)

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Article Multidisciplinary Sciences

Neoantigen-directed immune escape in lung cancer evolution

Rachel Rosenthal et al.

NATURE (2019)

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Article Multidisciplinary Sciences

Deconvolution of single-cell multi-omics layers reveals regulatory heterogeneity

Longqi Liu et al.

NATURE COMMUNICATIONS (2019)

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Article Biochemistry & Molecular Biology

An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity

Oded Kopper et al.

NATURE MEDICINE (2019)

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Article Multidisciplinary Sciences

Cancer stemness, intratumoral heterogeneity, and immune response across cancers

Alex Miranda et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

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Review Cell Biology

Intratumoral Heterogeneity: More Than Just Mutations

Kunihiko Hinohara et al.

TRENDS IN CELL BIOLOGY (2019)

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Article Multidisciplinary Sciences

Stem cell-associated heterogeneity in Glioblastoma results from intrinsic tumor plasticity shaped by the microenvironment

Anne Dirkse et al.

NATURE COMMUNICATIONS (2019)

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Article Biochemistry & Molecular Biology

Stromal Microenvironment Shapes the Intratumoral Architecture of Pancreatic Cancer

Matteo Ligorio et al.

CELL (2019)

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Article Cell Biology

Subclonal cooperation drives metastasis by modulating local and systemic immune microenvironments

Michalina Janiszewska et al.

NATURE CELL BIOLOGY (2019)

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Review Multidisciplinary Sciences

Cancer modeling meets human organoid technology

David Tuveson et al.

SCIENCE (2019)

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Article Biochemistry & Molecular Biology

UVB-Induced Tumor Heterogeneity Diminishes Immune Response in Melanoma

Yochai Wolf et al.

CELL (2019)

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Article Multidisciplinary Sciences

Metastatic-niche labelling reveals parenchymal cells with stem features

Luigi Ombrato et al.

NATURE (2019)

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Article Biotechnology & Applied Microbiology

High-throughput sequencing of the transcriptome and chromatin accessibility in the same cell

Song Chen et al.

NATURE BIOTECHNOLOGY (2019)

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Article Multidisciplinary Sciences

Patient-derived lung cancer organoids as in vitro cancer models for therapeutic screening

Minsuh Kim et al.

NATURE COMMUNICATIONS (2019)

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Article Multidisciplinary Sciences

Distinct initiating events underpin the immune and metabolic heterogeneity of KRAS-mutant lung adenocarcinoma

Sarah A. Best et al.

NATURE COMMUNICATIONS (2019)

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Article Multidisciplinary Sciences

Fate-mapping post-hypoxic tumor cells reveals a ROS-resistant phenotype that promotes metastasis

Ines Godet et al.

NATURE COMMUNICATIONS (2019)

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Review Oncology

Cancer immunoediting and resistance to T cell-based immunotherapy

Jake S. O'Donnell et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2019)

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Article Biotechnology & Applied Microbiology

Quantitative Visualization of Hypoxia and Proliferation Gradients Within Histological Tissue Sections

Mark Zaidi et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2019)

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Article Oncology

An analysis of genetic heterogeneity in untreated cancers

Johannes G. Reiter et al.

NATURE REVIEWS CANCER (2019)

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Article Oncology

Fibroblast Heterogeneity and Immunosuppressive Environment in Human Breast Cancer

Ana Costa et al.

CANCER CELL (2018)

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Article Biochemistry & Molecular Biology

A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity

Norman Sachs et al.

CELL (2018)

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Article Biochemistry & Molecular Biology

Deterministic Evolutionary Trajectories Influence Primary Tumor Growth: TRACERx Renal

Samra Turajlic et al.

CELL (2018)

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Article Multidisciplinary Sciences

scNMT-seq enables joint profiling of chromatin accessibility DNA methylation and transcription in single cells

Stephen J. Clark et al.

NATURE COMMUNICATIONS (2018)

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Article Multidisciplinary Sciences

Necroptosis microenvironment directs lineage commitment in liver cancer

Marco Seehawer et al.

NATURE (2018)

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Review Cell Biology

The Different Routes to Metastasis via Hypoxia-Regulated Programs

Ana Rita Nobre et al.

TRENDS IN CELL BIOLOGY (2018)

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Article Multidisciplinary Sciences

Differentiation-state plasticity is a targetable resistance mechanism in basal-like breast cancer

Tyler Risom et al.

NATURE COMMUNICATIONS (2018)

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Article Oncology

KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance

Kunihiko Hinohara et al.

CANCER CELL (2018)

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Article Biochemistry & Molecular Biology

Organoid Modeling of the Tumor Immune Microenvironment

James T. Neal et al.

CELL (2018)

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Article Multidisciplinary Sciences

Rainbow-Seq: Combining Cell Lineage Tracing with Single-Cell RNA Sequencing in Preimplantation Embryos

Fernando H. Biase et al.

ISCIENCE (2018)

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Article Multidisciplinary Sciences

Visualization and targeting of LGR5+ human colon cancer stem cells

Mariko Shimokawa et al.

NATURE (2017)

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Article Multidisciplinary Sciences

Intratumoural heterogeneity generated by Notch signalling promotes small-cell lung cancer

Jing Shan Lim et al.

NATURE (2017)

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Article Multidisciplinary Sciences

A Wnt-producing niche drives proliferative potential and progression in lung adenocarcinoma

Tuomas Tammela et al.

NATURE (2017)

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Article Multidisciplinary Sciences

Polylox barcoding reveals haematopoietic stem cell fates realized in vivo

Weike Pei et al.

NATURE (2017)

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Article Cell Biology

Phenotypic heterogeneity of disseminated tumour cells is preset by primary tumour hypoxic microenvironments

Georg Fluegen et al.

NATURE CELL BIOLOGY (2017)

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Article Biochemistry & Molecular Biology

Human primary liver cancer-derived organoid cultures for disease modeling and drug screening

Laura Broutier et al.

NATURE MEDICINE (2017)

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Article Biochemical Research Methods

Simultaneous epitope and transcriptome measurement in single cells

Marlon Stoeckius et al.

NATURE METHODS (2017)

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Article Medicine, Research & Experimental

Chromosomal Instability as a Driver of Tumor Heterogeneity and Evolution

Samuel F. Bakhoum et al.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2017)

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Article Biology

Simultaneous measurement of chromatin accessibility, DNA methylation, and nucleosome phasing in single cells

Sebastian Pott

ELIFE (2017)

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Review Cell Biology

Natural diversity facilitates the discovery of conserved chemotherapeutic response mechanisms

Stefan Zdraljevic et al.

CURRENT OPINION IN GENETICS & DEVELOPMENT (2017)

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Review Medicine, General & Internal

The role of tumour heterogeneity and clonal cooperativity in metastasis, immune evasion and clinical outcome

Deborah R. Caswell et al.

BMC MEDICINE (2017)

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Review Oncology

Pre-metastatic niches: organ-specific homes for metastases

Hector Peinado et al.

NATURE REVIEWS CANCER (2017)

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Review Oncology

Targeting neoantigens to augment antitumour immunity

Mark Yarchoan et al.

NATURE REVIEWS CANCER (2017)

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Review Biochemistry & Molecular Biology

Clonal Heterogeneity and Tumor Evolution: Past, Present, and the Future

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