期刊
NATURE BIOTECHNOLOGY
卷 40, 期 12, 页码 1774-U20出版社
NATURE PORTFOLIO
DOI: 10.1038/s41587-022-01368-1
关键词
-
资金
- Crohn's & Colitis foundation [675191, U19 AG063744 01, R01AG061066, 1 DP1 AT010885, P30 DK120515]
- Office of Naval Research MURI [N00014-15-1-2809]
- NIH/NCATS Colorado CTSA Grant [UL1TR002535]
- Emch Fund
- CD Fund
- Chancellor's Initiative in the Microbiome and Microbial Sciences
- Center for Microbiome Innovation at UCSD
- SD IRACDA [5K12GM06852417]
- USDA-NIFA [2019-67013-29137]
- Einstein Institute GOLD project [R01MD011389]
- Krupp Endowed Fund
- NIH/NIAMS [AR060772, AR075990]
- Danone Nutricia Research
- UCSD Rheumatic Diseases Research Training Grant from the NIH/NIAMS [T32AR064194]
- UCSD training grant from the NIH/NIDDK Gastroenterology Training Program [T32 DK007202]
- Brazilian National Council for Scientific and Technological Development (CNPq)-Brazil [245954/2012]
- FAPESP [2014/50265-3]
- NIH/NHLBI Training Grant [NIH T32 HL149646]
- PROMOS fund (DAAD)
- NIH [DP2 AT010401-01]
- National Institute on Aging [1U01AG061359-01, R01AG046171, RF1 AG0151550]
- NIA [1RF1AG058942-01, 3U01 AG024904-09S4]
- National Institutes of Health [U01 AG024904]
- National Institute on Aging
- National Institute of Biomedical Imaging and Bioengineering
- AbbVie
- Alzheimer's Association
- Alzheimer's Drug Discovery Foundation
- Araclon Biotech
- BioClinica, Inc.
- Biogen
- Bristol-Myers Squibb Company
- CereSpir, Inc.
- Cogstate
- Eisai Inc.
- Elan Pharmaceuticals, Inc.
- Eli Lilly and Company
- EuroImmun
- F. Hoffmann-La Roche Ltd
- Genentech, Inc.
- Fujirebio
- GE Healthcare
- IXICO Ltd
- Janssen Alzheimer Immunotherapy Research & Development, LLC
- Johnson & Johnson Pharmaceutical Research & Development LLC
- Lumosity
- Lundbeck
- Merck Co., Inc.
- Meso Scale Diagnostics, LLC
- NeuroRx Research
- Neurotrack Technologies
- Novartis Pharmaceuticals Corporation
- Pfizer Inc.
- Piramal Imaging
- Servier
- Takeda Pharmaceutical Company
- Transition Therapeutics
- Canadian Institutes of Health Research
- UCSD Academic Senate Research/Bridge Grant
- Eunice Kennedy Shriver National Institute of Child Health and Human Development [K12-HD000850]
This study introduces a reference-data-driven analysis approach to increase the usage of metabolomics MS/MS data and enable empirical evaluation of dietary patterns from untargeted data.
Human untargeted metabolomics studies annotate only similar to 10% of molecular features. We introduce reference-data-driven analysis to match metabolomics tandem mass spectrometry (MS/MS) data against metadata-annotated source data as a pseudo-MS/MS reference library. Applying this approach to food source data, we show that it increases MS/MS spectral usage 5.1-fold over conventional structural MS/MS library matches and allows empirical assessment of dietary patterns from untargeted data.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据
分享论文
