4.8 Article

Targeting thalamic circuits rescues motor and mood deficits in PD mice

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Multidisciplinary Sciences

Thalamic projections to the subthalamic nucleus contribute to movement initiation and rescue of parkinsonian symptoms

Glenn D. R. Watson et al.

Summary: The parafascicular nucleus (Pf) of the thalamus projects to the subthalamic nucleus (STN) and is responsible for movement initiation. Stimulation of Pf-STN projections can ameliorate movement deficits in a mouse model of Parkinson's disease.

SCIENCE ADVANCES (2021)

Article Biochemistry & Molecular Biology

Functional analysis of distinct populations of subthalamic nucleus neurons on Parkinson's disease and OCD-like behaviors in mice

Luca Parolari et al.

Summary: The study anatomically characterized molecular markers for specific STN neurons, revealing Pitx2, Gabrr3, Ndnf, and Nos1 expression. Optogenetic studies showed that Gabrr3 neurons play a key role in mediating the beneficial effects of STN modulation, serving as potential cellular targets for PD and OCD drug discovery.

MOLECULAR PSYCHIATRY (2021)

Article Neurosciences

Anterior thalamic dysfunction underlies cognitive deficits in a subset of neuropsychiatric disease models

Dheeraj S. Roy et al.

Summary: The study identified specific gene expressions in the anterior thalamic nuclei related to autism and schizophrenia, affecting memory functions. Different areas within the nuclei have distinct functions in memory encoding, with regulation of neuronal excitability playing a role in memory deficits. The findings suggest converging cellular mechanisms underlying cognitive deficits in certain neuropsychiatric disease models.

NEURON (2021)

Review Anatomy & Morphology

Anatomy and Connectivity of the Subthalamic Nucleus in Humans and Non-human Primates

Aron Emmi et al.

FRONTIERS IN NEUROANATOMY (2020)

Article Chemistry, Medicinal

DREADD Agonist 21 Is an Effective Agonist for Muscarinic-Based DREADDs in Vitro and in Vivo

Karen J. Thompson et al.

ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE (2018)

Article Biochemical Research Methods

qMotor, a set of rules for sensitive, robust and quantitative measurement of motor performance in mice

Laura M. Luh et al.

NATURE PROTOCOLS (2017)

Article Multidisciplinary Sciences

Lhx6-positive GABA-releasing neurons of the zona incerta promote sleep

Kai Liu et al.

NATURE (2017)

Review Clinical Neurology

The many facets of motor learning and their relevance for Parkinson's disease

Lucio Marinelli et al.

CLINICAL NEUROPHYSIOLOGY (2017)

Article Neurosciences

Intralaminar and tectal projections to the subthalamus in the rat

Takako Kita et al.

EUROPEAN JOURNAL OF NEUROSCIENCE (2016)

Article Multidisciplinary Sciences

Memory retrieval by activating engram cells in mouse models of early Alzheimer's disease

Dheeraj S. Roy et al.

NATURE (2016)

Article Neurosciences

Pathway-Specific Remodeling of Thalamostriatal Synapses in Parkinsonian Mice

Philip R. L. Parker et al.

NEURON (2016)

Review Neurosciences

Reassessing Models of Basal Ganglia Function and Dysfunction

Alexandra B. Nelson et al.

ANNUAL REVIEW OF NEUROSCIENCE, VOL 37 (2014)

Article Multidisciplinary Sciences

Engineering a memory with LTD and LTP

Sadegh Nabavi et al.

NATURE (2014)

Article Multidisciplinary Sciences

Axonal and subcellular labelling using modified rabies viral vectors

Ian R. Wickersham et al.

NATURE COMMUNICATIONS (2013)

Review Neurosciences

Neuronal nicotinic acetylcholine receptors: neuroplastic changes underlying alcohol and nicotine addictions

Allison A. Feduccia et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2012)

Article Biochemistry & Molecular Biology

Schizophrenia susceptibility pathway neuregulin 1-ErbB4 suppresses Src upregulation of NMDA receptors

Graham M. Pitcher et al.

NATURE MEDICINE (2011)

Article Clinical Neurology

Non-motor symptoms in Parkinson's disease

W. Poewe

EUROPEAN JOURNAL OF NEUROLOGY (2008)

Article Neurosciences

ErbB4 is a suppressor of long-term potentiation in the adult hippocampus

Graham M. Pitcher et al.

NEUROREPORT (2008)

Article Neurosciences

Expression of the mRNAs encoding for the vesicular glutamate transporters 1 and 2 in the rat thalamus

Pedro Barroso-Chinea et al.

JOURNAL OF COMPARATIVE NEUROLOGY (2007)

Article Multidisciplinary Sciences

Genome-wide atlas of gene expression in the adult mouse brain

Ed S. Lein et al.

NATURE (2007)

Article Clinical Neurology

GABAergic interneurons in human subthalamic nucleus

JC Lévesque et al.

MOVEMENT DISORDERS (2005)

Article Pharmacology & Pharmacy

Analogs of α-conotoxin MII are selective for α6-containing nicotinic acetylcholine receptors

JM McIntosh et al.

MOLECULAR PHARMACOLOGY (2004)

Review Neurosciences

Putting a spin on the dorsal-ventral divide of the striatum

P Voorn et al.

TRENDS IN NEUROSCIENCES (2004)

Review Clinical Neurology

The subthalamic nucleus in the context of movement disorders

C Hamani et al.