期刊
NATURAL PRODUCT RESEARCH
卷 37, 期 6, 页码 944-955出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2022.2098957
关键词
Aspergillus flavus; biotransformation; carvone; camphor; cytotoxicity; monoterpene
In this study, the biotransformation of carvone and camphor by Aspergillus flavus was investigated and the resulting products were analyzed. It was observed that the biotransformation products exhibited cytotoxicity against breast cancer cells and significant inhibition against aflatoxin B1.
In this study, the biotransformation of carvone and camphor by Aspergillus flavus and the products were investigated. The biotransformation reaction of carvone by A. flavus resulted in the production of neodihydrocarveol, dihydrocarvone, 2-cyclohexene-1-one,2-methyl-5-(1-methylethenyl), limonene-1,2-diol, trans-p-mentha-1(7),8-dien-2-ol, p-menth-8(10)-ene-2,9-diol, and the biotransformation reaction of camphor resulted in the production of 2 -campholenic acid, 2-cyclohexene-1-one,2-hydroxy-4,4,6,6-tetramethyl, alpha-campholene aldehyde. The naturally produced essential oils by biotransformation of carvone and camphor were observed to be cytotoxic to breast cancer cells while no significant inhibition was seen in the healthy cell line. Additionally, biotransformation products had the highest inhibition (74%) against aflatoxin B1. The bioactivities of biotransformation products are promising, and they can be further investigated for their therapeutic potential as active agents.
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