期刊
NATURAL PRODUCT RESEARCH
卷 37, 期 5, 页码 823-828出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2022.2089881
关键词
Anti-inflammation; Artemisia princeps; heme oxygenase-1; nitric oxide synthase; sesquiterpene
Four sesquiterpenoids were isolated from A. princeps ethanolic extract, and they showed anti-inflammatory activity by up-regulating the Nrf2/HO-1 pathway.
Four sesquiterpenoids were isolated from an ethyl acetate-soluble fraction of A. princeps ethanolic extract: seco-tanapartholide B (5-epi-seco-tanapartholide A) (1), 4-epi-seco-tanapartholide A (2), 11,13-dehydrodesacetylmatricarin (3) and desacetylmatricarin (4). Compounds 1 - 3 dose-dependently inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)-activated macrophages. These compounds also decreased mRNA and protein expression levels of inducible NO synthase and cyclooxygenase-2 as well as mRNA levels of pro-inflammatory cytokines (interleukin-1 beta and tumour necrosis factor-alpha) in LPS-stimulated RAW 264.7 macrophages. Moreover, compound 3 effectively enhanced the expression of heme oxygenase-1 (HO-1) in macrophages in the presence or absence of LPS. Additionally, the exocyclic methylene of alpha-methylene-gamma-lactone moiety of compound 3 was found to be essential for the activation of the NF erythroid 2-related factor 2 (Nrf2)/HO-1 pathway. Here, we firstly report the isolation of compounds 3 and 4 from A. princeps and the anti-inflammatory activity of compound 3 by up-regulation of Nrf2/HO-1 pathway.
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