期刊
NATURAL PRODUCT RESEARCH
卷 37, 期 10, 页码 1601-1607出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2022.2103126
关键词
Cullen corylifolium; Fabaceae; flavonoid; obesity; DGAT
In this study, a new flavonoid was isolated from the seeds of Cullen corylifolium and evaluated for its inhibitory activity against DGAT. Additionally, a summary of 45 other flavonoids and their structure-activity relationships were discussed.
A large number of extracts of medicinal plants or natural products shows beneficial to combat obesity. In the present work, a new flavonoid named (2S,1 '' R,2 '' R)-4 '-hydroxy-7-methoxy-6-(1,2,3-trihydroxy-3-methyl-butyl)-flavanone (1), along with seven known compounds (2-8) were isolated from the seeds of Cullen corylifolium. Their structures, including the absolute configurations, were determined by the analysis of comprehensive spectroscopic data and computational calculation methods. All isolates were evaluated for their diacylglycerol acyltransferase (DGAT) inhibitory activity. Compounds 1-4 exhibited different level of DGAT1 inhibitory activity with IC50 values ranging from 28.2 +/- 1.1 to 127.3 +/- 1.9 mu M. In addition, 45 flavonoids which be evaluated for DGAT inhibitory activity were summarised and potential structure-activity relationships were discussed.
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