期刊
NANO RESEARCH
卷 15, 期 8, 页码 7267-7285出版社
TSINGHUA UNIV PRESS
DOI: 10.1007/s12274-022-4385-4
关键词
drug delivery; vaccine; protein/peptide; self-assembly; targeting; controlled release
类别
资金
- National Key Research and Development Program of China [2019YFA0905200]
- National Natural Science Foundation of China [82072045]
- Natural Science Foundation of Jiangsu Province of China for Excellent Young Scholars [BK20190084]
Protein/peptide-based nanoassemblies are widely used in drug delivery and vaccine development due to their well-defined architecture, accurate molecular weight, excellent biocompatibility and biodegradability, and easy-to-functionalization. Inspired by nature, self-assembling proteins/peptides have been explored and designed to generate nanoassemblies with unique structure and function. This review summarizes the recent advances in protein/peptide-based nanoassemblies, including protein nanocages, virus-like particles, self-assemblable natural proteins, and self-assemblable artificial peptides, and discusses the prospects and challenges for further development.
Proteins have been widely used in the biomedical field because of their well-defined architecture, accurate molecular weight, excellent biocompatibility and biodegradability, and easy-to-functionalization. Inspired by the wisdom of nature, increasing proteins/peptides that possess self-assembling capabilities have been explored and designed to generate nanoassemblies with unique structure and function, including spatially organized conformation, passive and active targeting, stimuli-responsiveness, and high stability. These characteristics make protein/peptide-based nanoassembly an ideal platform for drug delivery and vaccine development. In this review, we focus on recent advances in subsistent protein/peptide-based nanoassemblies, including protein nanocages, virus-like particles, self-assemblable natural proteins, and self-assemblable artificial peptides. The origin and characteristics of various protein/peptide-based assemblies and their applications in drug delivery and vaccine development are summarized. In the end, the prospects and challenges are discussed for the further development of protein/peptide-based nanoassemblies.
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