期刊
MULTIPLE SCLEROSIS JOURNAL
卷 29, 期 2, 页码 295-300出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/13524585221114247
关键词
MRI; thalamus; thalamic nuclei; segmentation; volumetry; differential vulnerability
This study investigated the differential vulnerability of thalamic nuclei in multiple sclerosis (MS). The results showed that the thalamic nuclei closest to the third ventricle were more affected and had implications for cognitive function.
Objectives: Investigating differential vulnerability of thalamic nuclei in multiple sclerosis (MS). Methods: In a secondary analysis of prospectively collected datasets, we pooled 136 patients with MS or clinically isolated syndrome and 71 healthy controls all scanned with conventional 3D-T1 and white-matter-nulled magnetization-prepared rapid gradient echo (WMn-MPRAGE) and tested for cognitive performance. T1-based thalamic segmentation was compared with the reference WMn-MPRAGE method. Volumes of thalamic nuclei were compared according to clinical phenotypes and cognitive profile. Results: T1- and WMn-MPRAGE provided comparable segmentations (0.84 +/- 0.13 < volume-similarity-index < 0.95 +/- 0.03). Medial and posterior thalamic groups were significantly more affected than anterior and lateral groups. Cognitive impairment related to volume loss of the anterior group. Conclusion: Thalamic nuclei closest to the third ventricle are more affected, with cognitive consequences.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据