期刊
JOURNAL OF CYSTIC FIBROSIS
卷 15, 期 3, 页码 357-365出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jcf.2015.09.004
关键词
Cystic fibrosis; Pulmonary infection-colonization; Respiratory pathogens; P. aeruginosa
资金
- Instituto de Salud Carlos III of Spain [PI12/00734, PI12/00103]
- European Development Regional Fund (A Way to Achieve Europe program)
- European Development Regional Fund (Spanish Network for Research in Infectious Diseases) [REIPI RD12/0015]
Background: Clinical and demographical knowledge on Spanish cystic fibrosis (CF) patients is incomplete as no national registry exists. CF-microbiology has not been studied at national level. The results of the first Spanish multicenter study on CF microbiology are presented. Methods: 24 CF-Units for adult (n = 12) and pediatric (n = 12) patients from 17 hospitals provided sputa and clinical data from 15 consecutive patients. Cultures and susceptibility testing were performed. Colonization impact on pulmonary function was assessed. Results: 341 patients [mean (SD) age 21 (11) years, 180 >= 18 years, mean (SD) FEV1 = 68 (25)%] were included. Pseudomonas aeruginosa was reported as chronic, intermittent or absent in 46%, 22% and 32% of patients, respectively. The annual prevalence was 62%. Positive P. aeruginosa and methicillin-resistant Staphylococcus aureus cultures were significantly associated with lower FEV1 (p < 0.001 and p = 0.003, respectively). Conclusions: The representative subset of the Spanish CF-population which has been clinically, demographically and microbiologically. characterized will serve as a reference for future CF studies in Spain. (C) 2015 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据