Chemical Composition, Anti-Breast Cancer Activity and Extraction Techniques of Ent-Abietane Diterpenoids from Euphorbia fischeriana Steud

Article Plant Sciences

Jolkinolide B alleviates renal fibrosis via anti-inflammation and inhibition of epithelial-mesenchymal transition in unilateral ureteral obstruction mice

Mei Li et al.

Summary: The study demonstrates that Jolkinolide B can reduce renal fibrosis by inhibiting inflammation through the NF-κB pathway and reversing epithelial-mesenchymal transition mediated by the TGF-β1/Smad pathway.

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH (2022)

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Article Chemistry, Medicinal

An unusual indole-diterpenoid with C-17 norcassane skeleton from Euphorbia fischeriana induces HEL cell cycle arrest and apoptosis

Bei-Ling Chen et al.

Summary: Two new polycyclic diterpenoids were isolated from the roots of Euphorbia fischeriana, and one of them showed significant cytotoxicity against HEL cells, inducing cell cycle arrest and apoptosis.

FITOTERAPIA (2022)

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Review Chemistry, Analytical

Homogeneous liquid-liquid extraction as an alternative sample preparation technique for biomedical analysis

Sherin F. Hammad et al.

Summary: Homogeneous liquid-liquid extraction is an alternative sample preparation technique that overcomes some drawbacks of conventional liquid-liquid extraction, and is more suitable for the extraction of delicate macromolecules while showing better performance in liquid chromatography with tandem mass spectrometry.

JOURNAL OF SEPARATION SCIENCE (2022)

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Article Chemistry, Analytical

A strategy for the rapid discovery and validation of active diterpenoids as quality markers in different habitats of Langdu using ultrahigh-performance liquid chromatography-tandem mass spectrometry with multivariate statistical analysis

Linlin Fang et al.

Summary: This study developed a fast and sensitive analytical method for the quality control of Langdu, a traditional Chinese medicine, and identified key bioactive components. This will improve the qualitative control methodology for Langdu as an important medicine.

JOURNAL OF SEPARATION SCIENCE (2022)

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Article Biochemistry & Molecular Biology

Bisfischoids A and B, dimeric ent-abietane-type diterpenoids with anti-inflammatory potential from Euphorbia fischeriana Steud.

Cheng-Peng Sun et al.

Summary: Two undescribed ent-abietane-type diterpenoid dimers with nonacyclic backbone, bisfischoids A and B, were identified, along with a known compound fischdiabietane A, from Euphorbia fischeriana Steud. These compounds showed promising anti-inflammatory activities by inhibiting soluble epoxide hydrolase, with bisfischoid B exhibiting the strongest inhibitory effect. Further molecular docking studies revealed the key amino acid residue Tyr343 in the catalytic cavity of sEH for their inhibitory function.

BIOORGANIC CHEMISTRY (2021)

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Article Biochemistry & Molecular Biology

Euphorfistrines A-G, cytotoxic and AChE inhibiting triterpenoids from the roots of Euphorbia fischeriana

Jiang-Chun Wei et al.

Summary: Seven new triterpenoids, along with nineteen known triterpenoids, were isolated from the roots of Euphorbia fischeriana. Bioassays showed that some of these compounds exhibited moderate cytotoxic effects and inhibitory activity against AChE. In particular, triterpenoid 7 (ETG) demonstrated potent inhibitory effects and in silico docking analyses were conducted to investigate its mechanism of action.

BIOORGANIC CHEMISTRY (2021)

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Article Biochemistry & Molecular Biology

Euphorfinoids E-L: Diterpenoids from the roots of Euphorbia fischeriana with acetylcholinesterase inhibitory activity

Jiang-Chun Wei et al.

Summary: This study isolated eight new diterpenoids from the roots of wild Euphorbia fischeriana, identified their structures and absolute configurations, and proposed a plausible biosynthetic pathway. These compounds showed moderate inhibitory activity against acetylcholinesterase, with IC50 values ranging from 6.23 to 192.38 µM.

PHYTOCHEMISTRY (2021)

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Article Biochemical Research Methods

Simultaneous LC-MS/MS bioanalysis of alkaloids, terpenoids, and flavonoids in rat plasma through salting-out-assisted liquid-liquid extraction after oral administration of extract from Tetradium ruticarpum and Glycyrrhiza uralensis: a sample preparation strategy to broaden analyte coverage of herbal medicines

Manlin Li et al.

Summary: The study aimed to improve analyte coverage by evaluating six protocols for sample pretreatment methods, with SALLE producing broader analyte coverage with satisfactory reproducibility, acceptable recovery, and low matrix interference. The developed SALLE method showed good sensitivity, linearity, precision, accuracy, and stability, making it suitable for pharmacokinetic studies of herbal medicines.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2021)

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Review Plant Sciences

Existing knowledge on Euphorbia fischeriana Steud. (Euphorbiaceae): Traditional uses, clinical applications, phytochemistry, pharmacology and toxicology

Ya-Nan Li et al.

Summary: Euphorbia fischeriana has been identified as a toxic herb with medicinal uses for various conditions. A total of 241 chemical constituents have been found in its roots, exhibiting various pharmacological activities, especially anti-tumor, antibacterial, anti-inflammatory, antiviral, and anti-leukemia activities. Further research on its toxicity and pharmacological mechanisms may contribute to the development of more effective lead compounds.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

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Article Biochemistry & Molecular Biology