期刊
MOLECULES
卷 27, 期 15, 页码 -出版社
MDPI
DOI: 10.3390/molecules27154901
关键词
thiocoumarins; 2-thioxocoumarins; dithiocoumarins; synthesis; biological applications
资金
- Ministerio de Ciencia e Innovacion [PID2020-116076RJI00/AEI/10.13039/501100011033]
- Fundacao para aCiencia e Tecnologia [PTDC/ASP-PES/28397/2017, CEECIND/02423/2018, UIDB/00081/2020, LA/P/0056/2020, EXPL/BIA-BQM/0492/2021]
- University of Porto
- University of Santiago de Compostela
- Fundação para a Ciência e a Tecnologia [PTDC/ASP-PES/28397/2017, EXPL/BIA-BQM/0492/2021] Funding Source: FCT
This article provides a review of the synthesis and biological applications of thiocoumarins and their derivatives. It emphasizes their potential as drug candidates and highlights the research progress in the past 5 years. The information presented is based on data collected from multiple electronic databases.
Coumarin is a privilege scaffold in medicinal chemistry. Coumarin derivatives are still an emerging class of highly potent pharmaceutical drugs, best known in the field of antimicrobials and anticoagulants. Thiocoumarins are a particular class of coumarins in which one or two of the oxygen atoms are replaced by a sulfur. They are chemically subdivided in three groups: Thiocoumarins, 2-thioxocoumarins, and dithiocoumarins. This review emphasizes the rationale behind the synthesis and biological applications of the most relevant publications related to this family of compounds. Particular attention has been given to their potential as drug candidates, with particular emphasis in the last 5 years. This article is based on the most relevant information collected from multiple electronic databases, including SciFinder, Pubmed, Espacenet, and Mendeley.
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