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Anti-Cancer Effects of Dietary Polyphenols via ROS-Mediated Pathway with Their Modulation of MicroRNAs

期刊

MOLECULES
卷 27, 期 12, 页码 -

出版社

MDPI
DOI: 10.3390/molecules27123816

关键词

dietary polyphenols; microRNA; cancer; reactive oxygen species; anticancer pathway

资金

  1. Japanese Ministry of Education, Culture, Sports, Science, and Technology (MEXT, Tokyo) [20H04109]
  2. Grants-in-Aid for Scientific Research [20H04109] Funding Source: KAKEN

向作者/读者索取更多资源

Consumption of coffee, tea, wine, curry, and soybeans has been linked to a lower risk of cancer. Polyphenols play a major role in the anticancer effects of these foods, influencing ROS-mediated pathways and miR expression. Further research can provide more convincing evidence.
Consumption of coffee, tea, wine, curry, and soybeans has been linked to a lower risk of cancer in epidemiological studies. Several cell-based and animal studies have shown that dietary polyphenols like chlorogenic acid, curcumin, epigallocatechin-3-O-gallate, genistein, quercetin and resveratrol play a major role in these anticancer effects. Several mechanisms have been proposed to explain the anticancer effects of polyphenols. Depending on the cellular microenvironment, these polyphenols can exert double-faced actions as either an antioxidant or a prooxidant, and one of the representative anticancer mechanisms is a reactive oxygen species (ROS)-mediated mechanism. These polyphenols can also influence microRNA (miR) expression. In general, they can modulate the expression/activity of the constituent molecules in ROS-mediated anticancer pathways by increasing the expression of tumor-suppressive miRs and decreasing the expression of oncogenic miRs. Thus, miR modulation may enhance the anticancer effects of polyphenols through the ROS-mediated pathways in an additive or synergistic manner. More precise human clinical studies on the effects of dietary polyphenols on miR expression will provide convincing evidence of the preventive roles of dietary polyphenols in cancer and other diseases.

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