期刊
MOLECULES
卷 27, 期 13, 页码 -出版社
MDPI
DOI: 10.3390/molecules27133970
关键词
IONP-GA; PAA; ferroptosis; cancer cells
资金
- VLIR (Belgium) [CU2018TEA457A103]
- Ministerio de Ciencia Tecnologia y Medio Ambiente (Cuba) [PN223LH010-035]
The use of iron-based polymeric nanoparticles (IONP-GA/PAA) coated with gallic acid and polyacrylic acid has shown to efficiently induce ferroptosis in various cancer cell lines, making it a potential therapeutic strategy for tumor treatment. The ferroptosis-inducing effect of IONP-GA/PAA can be blocked by canonical ferroptosis inhibitors, and these inhibitors also prevent the generation of lipid hydroperoxide promoted by the nanoparticles.
The use of nanomaterials rationally engineered to treat cancer is a burgeoning field that has reported great medical achievements. Iron-based polymeric nano-formulations with precisely tuned physicochemical properties are an expanding and versatile therapeutic strategy for tumor treatment. Recently, a peculiar type of regulated necrosis named ferroptosis has gained increased attention as a target for cancer therapy. Here, we show for the first time that novel iron oxide nanoparticles coated with gallic acid and polyacrylic acid (IONP-GA/PAA) possess intrinsic cytotoxic activity on various cancer cell lines. Indeed, IONP-GA/PAA treatment efficiently induces ferroptosis in glioblastoma, neuroblastoma, and fibrosarcoma cells. IONP-GA/PAA-induced ferroptosis was blocked by the canonical ferroptosis inhibitors, including deferoxamine and ciclopirox olamine (iron chelators), and ferrostatin-1, the lipophilic radical trap. These ferroptosis inhibitors also prevented the lipid hydroperoxide generation promoted by the nanoparticles. Altogether, we report on novel ferroptosis-inducing iron encapsulated nanoparticles with potent anti-cancer properties, which has promising potential for further in vivo validation.
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