期刊
MOLECULES
卷 27, 期 12, 页码 -出版社
MDPI
DOI: 10.3390/molecules27123661
关键词
triple-negative breast cancer (TNBC); cell lines inhibitors; natural compounds
资金
- Academic Leadership Grant of Universitas Padjadjaran [1959/UN6.3.1/PT.00/2022]
Triple-negative breast cancer (TNBC) is the most aggressive subtype with poor prognosis. Natural compounds have gained attention as potential therapeutic agents for TNBC and may offer solutions to drug resistance issues.
Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, having a poor prognosis and rapid metastases. TNBC is characterized by the absence of estrogen, progesterone, and human epidermal growth receptor-2 (HER2) expressions and has a five-year survival rate. Compared to other breast cancer subtypes, TNBC patients only respond to conventional chemotherapies, and even then, with limited success. Shortages of chemotherapeutic medication can lead to resistance, pressured index therapy, non-selectivity, and severe adverse effects. Finding targeted treatments for TNBC is difficult owing to the various features of cancer. Hence, identifying the most effective molecular targets in TNBC pathogenesis is essential for predicting response to targeted therapies and preventing TNBC cell metastases. Nowadays, natural compounds have gained attention as TNBC treatments, and have offered new strategies for solving drug resistance. Here, we report a systematic review using the database from Pubmed, Science Direct, MDPI, BioScince, Springer, and Nature for articles screening from 2003 to 2022. This review analyzes relevant signaling pathways and the prospect of utilizing natural compounds as a therapeutic agent to improve TNBC treatments in the future.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据