期刊
MOLECULES
卷 27, 期 12, 页码 -出版社
MDPI
DOI: 10.3390/molecules27123855
关键词
gum Arabic; curcumin; drug delivery system; Simulated Intestinal Fluid; Simulated Gastric Fluid; encapsulation efficiency; loading capacity; antioxidant activity; release rate
资金
- Minister of Research and Technology
- Higher Education Republic Indonesia through PDUPT Research Scheme [25749/UN7.P4.3/PP/2019]
Gum Arabic is a promising drug carrier for curcumin in drug delivery systems, improving its solubility and bioavailability. A concentration of 10% Gum Arabic is recommended for optimal encapsulation efficiency, loading capacity, and antioxidant activity. The simulated intestinal fluid provides a better environment compared to simulated gastric fluid.
Biopolymers, especially polysaccharides (e.g., gum Arabic), are widely applied as drug carriers in drug delivery systems due to their advantages. Curcumin, with high antioxidant ability but limited solubility and bioavailability in the body, can be encapsulated in gum Arabic to improve its solubility and bioavailability. When curcumin is encapsulated in gum Arabic, it is essential to understand how it works in various conditions. As a result, in Simulated Intestinal Fluid and Simulated Gastric Fluid conditions, we investigated the potential of gum Arabic as the drug carrier of curcumin. This study was conducted by varying the gum Arabic concentrations, i.e., 5, 10, 15, 20, 30, and 40%, to encapsulate 0.1 mg/mL of curcumin. Under both conditions, the greater the gum Arabic concentration, the greater the encapsulation efficiency and antioxidant activity of curcumin, but the worse the gum Arabic loading capacity. To achieve excellent encapsulation efficiency, loading capacity, and antioxidant activity, the data advises that 10% is the best feasible gum Arabic concentration. Regarding the antioxidant activity of curcumin, the findings imply that a high concentration of gum Arabic was effective, and the Simulated Intestinal Fluid brought an excellent surrounding compared to the Simulated Gastric Fluid solution. Moreover, the gum Arabic releases curcumin faster in the Simulated Gastric Fluid condition.
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