期刊
MOLECULES
卷 27, 期 11, 页码 -出版社
MDPI
DOI: 10.3390/molecules27113621
关键词
betulin; birch bark; pentacyclic triterpenoid; biological activity; methods of betulin isolation
资金
- Science Committee of the Ministry of Education and Science of the Republic of Kazakhstan
The isolation and extraction methods for betulin from birch bark are crucial for its potential medical applications, including vacuum sublimation, vacuum pyrolysis, supercritical extraction, and organic solvent extraction, each with its own advantages and disadvantages.
Betulin is the most popular of the known triterpenoids of the lupan series. It has valuable pharmacological properties. It exhibits antibacterial, antiviral, antitumor, hypolipidemic and other types of activity. The prospects of using betulin in medicine, pharmacology, and veterinary medicine require the development of effective methods for obtaining it from waste from the woodworking industry. Therefore, the question arises of the need to develop a technology for isolating and purifying triterpenoids from birch bark in large quantities. This review contains a variety of methods for the isolation of betulin. The advantages and disadvantages of the proposed methods are described. The following methods are considered: vacuum sublimation after preliminary alkaline; vacuum pyrolysis; supercritical extraction with carbon dioxide or mixtures of carbon dioxide with various solvents; extraction with organic solvents. Also, the method of microwave is described, it is activation on the example of the Kyrgyz birch (Betula kirghisorum), this is an endemic species that has not been studied before, growing on the territory of the Republic of Kazakhstan.
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