期刊
MOLECULES
卷 27, 期 12, 页码 -出版社
MDPI
DOI: 10.3390/molecules27123666
关键词
ylang-ylang; essential oil; inflammatory response; natural products
资金
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior-CAPES-Brazil [001]
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico-CNPq [426172/2018-3]
- Universidade Federal de Mato Grosso do Sul-UFMS [15/2022]
This study evaluated the phytochemical profile, oral acute toxicity, and the anti-inflammatory effect of ylang-ylang essential oil. The results showed that ylang-ylang essential oil affected leukocyte activation and had anti-edematogenic, anti-hyperalgesic, and anti-inflammatory properties.
The aim of this study is to evaluate the phytochemical profile, oral acute toxicity, and the effect of ylang-ylang (Cananga odorata Hook. F. & Thomson) essential oil (YEO) on acute inflammation. YEO was analyzed by gas chromatography/mass spectrometry. For in vitro tests, YEO was assessed using cytotoxicity, neutrophil chemotaxis induced by N-formyl methionyl leucyl phenylalanine (fMLP), and phagocytic activity tests. YEO was orally administered in zymosan-induced peritonitis, carrageenan-induced leukocyte rolling, and adhesion events in the in situ microcirculation model and in carrageenan-induced paw edema models. YEO (2000 mg/kg) was also tested using an acute toxicity test in Swiss mice. YEO showed a predominance of benzyl acetate, linalool, benzyl benzoate, and methyl benzoate. YEO did not present in vitro cytotoxicity. YEO reduced the in vitro neutrophil chemotaxis induced by fMLP and reduced the phagocytic activity. The oral treatment with YEO reduced the leukocyte recruitment and nitric oxide production in the zymosan-induced peritonitis model, reduced rolling and adherent leukocyte number induced by carrageenan in the in situ microcirculation model, and reduced carrageenan-induced edema and mechanical hyperalgesia. YEO did not present signs of toxicity in the acute toxicity test. In conclusion, YEO affected the leukocyte activation, and presented antiedematogenic, anti-hyperalgesic, and anti-inflammatory properties.
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