期刊
MOLECULES
卷 27, 期 16, 页码 -出版社
MDPI
DOI: 10.3390/molecules27165113
关键词
organocatalysis; binaphthylazepines; vibrational circular dichroism; flavanones; absolute configuration
资金
- [PON RI 2014-2020 BIOFEEDSTOCK (ARS01_00985)]
A novel alpha-tetrazole-substituted 1,1'-binaphthylazepine chiral catalyst has been synthesized and its absolute configuration has been determined using DFT computational analysis of the VCD spectrum. The catalyst showed low enantioselectivity in the synthesis of chiral flavanones.
A novel alpha-tetrazole-substituted 1,1 '-binaphthylazepine chiral catalyst has been synthesized and its absolute configuration has been determined by DFT computational analysis of the vibrational circular dichroism (VCD) spectrum of its precursor. The VCD analysis, carried out through the model averaging method, allowed to assign the absolute configuration of a benzylic stereocenter in the presence of a chiral binaphthyl moiety. The 1,1 '-binaphthylazepine tetrazole and the nitrile its immediate synthetic precursor, have been preliminarily tested as chiral organocatalysts in the asymmetric intramolecular oxa-Michael cyclization of 2-hydroxy chalcones for the synthesis of chiral flavanones obtaining low enantioselectivity.
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