4.6 Article

Synthesis and Biological Activity of Unsymmetrical Monoterpenylhetaryl Disulfides

期刊

MOLECULES
卷 27, 期 16, 页码 -

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MDPI
DOI: 10.3390/molecules27165101

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unsymmetrical; monoterpenylhetaryl disulfides; antioxidant; antibacterial; antifungal activity; cytotoxicity; mutagenicity

资金

  1. Russian Science Foundation [21-13-00245]

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New unsymmetrical monoterpenylhetaryl disulfides based on heterocyclic disulfides and monoterpene thiols were synthesized for the first time. The compounds were evaluated for antioxidant, antibacterial, antifungal activity, cytotoxicity and mutagenicity.
New unsymmetrical monoterpenylhetaryl disulfides based on heterocyclic disulfides and monoterpene thiols were synthesized for the first time in 48-88% yields. Hydrolysis of disulfides with fragments of methyl esters of 2-mercaptonicotinic acid was carried out in 73-95% yields. The obtained compounds were evaluated for antioxidant, antibacterial, antifungal activity, cytotoxicity and mutagenicity.

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