期刊
MOLECULAR PSYCHIATRY
卷 27, 期 10, 页码 4297-4306出版社
SPRINGERNATURE
DOI: 10.1038/s41380-022-01695-4
关键词
-
资金
- National Natural Science Foundation of China [82071212, 81901181]
- Beijing Natural Science Foundation [JQ21022]
- Mathematical Tianyuan Fund of the National Natural Science Foundation of China [12026414]
- Beijing Ten Thousand Talents Project [2020A15]
- Science and Technology Beijing One Hundred Leading Talent Training Project [Z141107001514006]
- Beijing Municipal Administration of Hospitals' Mission Plan [SML20150802]
- Funds of Academic Promotion Programme of Shandong First Medical University & Shandong Academy of Medical Sciences [2019QL016, 2019PT007]
This study used large-scale genome-wide association studies (GWAS) to investigate the causal relationship between educational attainment, cognitive performance, intelligence, and Alzheimer's disease (AD) through univariable and multivariable Mendelian-randomization (MR) analyses. The findings highlight the protective role of cognitive performance in AD, independently of educational attainment and intelligence.
Mendelian-randomization (MR) studies using large-scale genome-wide association studies (GWAS) have identified causal association between educational attainment and Alzheimer's disease (AD). However, the underlying mechanisms are still required to be explored. Here, we conduct univariable and multivariable MR analyses using large-scale educational attainment, cognitive performance, intelligence and AD GWAS datasets. In stage 1, we found significant causal effects of educational attainment on cognitive performance (beta = 0.907, 95% confidence interval (CI): 0.884-0.930, P < 1.145E-299), and vice versa (beta = 0.571, 95% CI: 0.557-0.585, P < 1.145E-299). In stage 2, we found that both increase in educational attainment (odds ratio (OR) = 0.72, 95% CI: 0.66-0.78, P = 1.39E-14) and cognitive performance (OR = 0.69, 95% CI: 0.64-0.75, P = 1.78E-20) could reduce the risk of AD. In stage 3, we found that educational attainment may protect against AD dependently of cognitive performance (OR = 1.07, 95% CI: 0.90-1.28, P = 4.48E-01), and cognitive performance may protect against AD independently of educational attainment (OR = 0.69, 95% CI: 0.53-0.89, P = 5.00E-03). In stage 4, we found significant causal effects of cognitive performance on intelligence (beta = 0.907, 95% CI: 0.877-0.938, P < 1.145E-299), and vice versa (beta = 0.957, 95% CI: 0.937-0.978, P < 1.145E-299). In stage 5, we identified that cognitive performance may protect against AD independently of intelligence (OR = 0.74, 95% CI: 0.61-0.90, P = 2.00E-03), and intelligence may protect against AD dependently of cognitive performance (OR = 1.17, 95% CI: 0.40-3.43, P = 4.48E-01). Collectively, our univariable and multivariable MR analyses highlight the protective role of cognitive performance in AD independently of educational attainment and intelligence. In addition to the intelligence, we extend the mechanisms underlying the associations of educational attainment with AD.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据