期刊
MOLECULAR PHARMACEUTICS
卷 19, 期 9, 页码 3323-3335出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.molpharmaceut.2c00472
关键词
Hyaluronic acid; ROS responsive; chemo-photothermal therapy
资金
- National Natural Science Foundation of China [82073794]
This article describes the development of a ROS-responsive nanoparticle that can overcome the limitations of chemotherapy and photothermal therapy. By integrating a photothermal agent into the nanoparticle, it shows high photothermal performance and remarkable tumor-targeting ability, enabling accurate drug delivery and achieving excellent chemo-photothermal treatment effect.
Combining chemotherapy with photothermal ther-apy (PTT) for cancer treatment could overcome the inherent limitations of both single-modality chemotherapy and PTT. However, the obstacle of accurate drug delivery to tumor sites based on chemo-photothermal remains challenging. This article describes development of a reactive oxygen species (ROS)-responsive hyaluronic acid-based nanoparticle to overcome these drawbacks. Herein, HA-TK-MTX (HTM) was synthesized by a ROS-responsive cleaved thioketal moiety linker (TK) of methotrexate (MTX) and hyaluronic acid (HA). Through hydrophobic interaction and pi-pi stacking interaction, a photothermal agent IR780 was integrated into the HTM, and the IR780/HTM nanoparticles (IHTM NPs) were obtained. The IHTM NPs show high photostability, excellent photothermal performance, remarkable tumor-targeting ability, and ROS sensibility. Due to the accurate drug delivery ability and superior chemo-photothermal treatment effect of IHTM NPs, the tumor inhibition rate reached 70.95% for 4T1 tumor-bearing mice. This work serves as a precedent for the chemo-photothermal therapy of cancer by rationally designing ROS-responsive nanoparticles.
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