期刊
MOLECULAR PHARMACEUTICS
卷 -, 期 -, 页码 -出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.molpharmaceut.2c00359
关键词
gallium-68; DOTA; positron emission tomography tracers; virus-like particle; hepatitis E viral nanoparticles; hepatotropism
资金
- Academy of Finland [298481, 318422, 320102]
- Alfred Kordelin Foundation
- US National Institute of Health [TR002866, CA198880, CA225266, EB021230]
- National Institute Food Agriculture [CADMCB-7399-H]
- FiDiPro
- Juselius Foundation
- UC STAIR programs
The study demonstrates that hepatitis E virus nanoparticles can be considered as promising theranostic nanocarriers, especially for hepatocyte-targeting therapies.
Targeted delivery of diagnostics and therapeutics offers essential advantages over nontargeted systemic delivery. These include the reduction of toxicity, the ability to reach sites beyond biological barriers, and the delivery of higher cargo concentrations to diseased sites. Virus-like particles (VLPs) can efficiently be used for targeted delivery purposes. VLPs are derived from the coat proteins of viral capsids. They are self-assembled, biodegradable, and homogeneously distributed. In this study, hepatitis E virus (HEV) VLP derivatives, hepatitis E virus nanoparticles (HEVNPs), were radiolabeled with gallium-68, and consequently, the biodistribution of the labeled [Ga-68]Ga-DOTA-HEVNPs was studied in mice. The results indicated that [Ga-68]Ga-DOTA-HEVNPs can be considered as promising theranostic nanocarriers, especially for hepatocyte-targeting therapies.
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