Strategies for Taste Masking of Orodispersible Dosage Forms: Time, Concentration, and Perception

Orodispersible dosage forms, characterized as quick dissolving and swallowing without water, have recently gained great attention from the pharmaceutical industry, as these forms can satisfy the needs of children, the elderly, and patients suffering from mental illnesses. However, poor taste by thorough exposure of the drugs' dissolution in the oral cavity hinders the effectiveness of the orodispersible dosage forms. To bridge this gap, we put forward three taste-masking strategies with respect to the intensity of time, concentration, and perception. We further investigated the raw material processing, the composition of auxiliary material, formulation techniques, and process control in each strategy and drew conclusions about their effects on taste masking.

Automated summary

Orodispersible dosage forms, which can be dissolved and swallowed without water, have attracted great attention in the pharmaceutical industry due to their suitability for children, the elderly, and patients with mental illnesses. However, the unpleasant taste resulting from drug dissolution in the oral cavity hinders the effectiveness of these dosage forms. To address this issue, we propose three taste-masking strategies based on time, concentration, and perception. We further investigate the impact of raw material processing, auxiliary material composition, formulation techniques, and process control on taste masking.