期刊
MOLECULAR NUTRITION & FOOD RESEARCH
卷 66, 期 18, 页码 -出版社
WILEY
DOI: 10.1002/mnfr.202200164
关键词
histone deacetylase inhibitor; microglia; neuroinflammation; Roseburia hominis; short-chain fatty acids
资金
- National Key R&D Program of China [2019YFA0905600]
- National Natural Science Foundation of China [82170557]
The potential probiotic Roseburia hominis shows anti-neuroinflammatory effects by inhibiting microglial activation and reducing proinflammatory cytokines in the brain. Treatment with propionate or butyrate also leads to decreased neuroinflammation. This study suggests that R. hominis could be a potential psychoprobiotic to reduce neuroinflammation.
Scope The gut microbiota plays a prominent role in gut-brain interactions and gut dysbiosis is involved in neuroinflammation. However, specific probiotics targeting neuroinflammation need to be explored. In this study, the antineuroinflammatory effect of the potential probiotic Roseburia hominis (R. hominis) and its underlying mechanisms is investigated. Methods and results First, germ-free (GF) rats are orally treated with R. hominis. Microglial activation, proinflammatory cytokines, levels of short-chain fatty acids, depressive behaviors, and visceral sensitivity are assessed. Second, GF rats are treated with propionate or butyrate, and microglial activation, proinflammatory cytokines, histone deacetylase 1 (HDAC1), and histone H3 acetyl K9 (Ac-H3K9) are analyzed. The results show that R. hominis administration inhibits microglial activation, reduces the levels of IL-1 alpha, INF-gamma, and MCP-1 in the brain, and alleviates depressive behaviors and visceral hypersensitivity in GF rats. Moreover, the serum levels of propionate and butyrate are increased significantly in the R. hominis-treated group. Propionate or butyrate treatment reduces microglial activation, the levels of proinflammatory cytokines and HDAC1, and promotes the expression of Ac-H3K9 in the brain. Conclusion These findings suggest that R. hominis alleviates neuroinflammation by producing propionate and butyrate, which serve as HDAC inhibitors. This study provides a potential psychoprobiotic to reduce neuroinflammation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据