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Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease
Alexandria Beilina et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
The Nutrient-Responsive Transcription Factor TFE3 Promotes Autophagy, Lysosomal Biogenesis, and Clearance of Cellular Debris
Jose A. Martina et al.
SCIENCE SIGNALING (2014)
iPSC-derived neurons from GBA1-associated Parkinson's disease patients show autophagic defects and impaired calcium homeostasis
David C. Schoendorf et al.
NATURE COMMUNICATIONS (2014)
Folliculin Regulates Ampk-Dependent Autophagy and Metabolic Stress Survival
Elite Possik et al.
PLOS GENETICS (2014)
PINK1 is degraded through the N-end rule pathway
Koji Yamano et al.
AUTOPHAGY (2013)
Effect of glucosylceramide on the biophysical properties of fluid membranes
Ana R. P. Varela et al.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2013)
PGC1α Expression Defines a Subset of Human Melanoma Tumors with Increased Mitochondrial Capacity and Resistance to Oxidative Stress
Francisca Vazquez et al.
CANCER CELL (2013)
Exit from Pluripotency Is Gated by Intracellular Redistribution of the bHLH Transcription Factor Tfe3
Joerg Betschinger et al.
CELL (2013)
Mitochondria and Quality Control Defects in a Mouse Model of Gaucher Disease-Links to Parkinson's Disease
Laura D. Osellame et al.
CELL METABOLISM (2013)
Transcription factor EB (TFEB) is a new therapeutic target for Pompe disease
Carmine Spampanato et al.
EMBO MOLECULAR MEDICINE (2013)
The hallmarks of Parkinson's disease
Paul M. A. Antony et al.
FEBS JOURNAL (2013)
A RANKL-PKCβ-TFEB signaling cascade is necessary for lysosomal biogenesis in osteoclasts
Mathieu Ferron et al.
GENES & DEVELOPMENT (2013)
Altered splicing of ATP6AP2 causes X-linked parkinsonism with spasticity (XPDS)
Olena Korvatska et al.
HUMAN MOLECULAR GENETICS (2013)
Modulation of Serines 17 and 24 in the LC3-interacting Region of Bnip3 Determines Pro-survival Mitophagy versus Apoptosis
Yanyan Zhu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Lewy Body-like α-Synuclein Aggregates Resist Degradation and Impair Macroautophagy
Selcuk A. Tanik et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Lysosomes shape Ins(1,4,5)P-3-evoked Ca2+ signals by selectively sequestering Ca2+ released from the endoplasmic reticulum
Cristina I. Lopez-Sanjurjo et al.
JOURNAL OF CELL SCIENCE (2013)
The Folliculin Tumor Suppressor Is a GAP for the RagC/D GTPases That Signal Amino Acid Levels to mTORC1
Zhi-Yang Tsun et al.
MOLECULAR CELL (2013)
ZKSCAN3 Is a Master Transcriptional Repressor of Autophagy
Santosh Chauhan et al.
MOLECULAR CELL (2013)
Autophagosomes form at ER-mitochondria contact sites
Maho Hamasaki et al.
NATURE (2013)
TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop
Carmine Settembre et al.
NATURE CELL BIOLOGY (2013)
Glucocerebrosidase inhibition causes mitochondrial dysfunction and free radical damage
Michael W. J. Cleeter et al.
NEUROCHEMISTRY INTERNATIONAL (2013)
Unfolded protein response in Gaucher disease: from human to Drosophila
Gali Maor et al.
ORPHANET JOURNAL OF RARE DISEASES (2013)
Augmenting CNS glucocerebrosidase activity as a therapeutic strategy for parkinsonism and other Gaucher-related synucleinopathies
S. Pablo Sardi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
TFEB-mediated autophagy rescues midbrain dopamine neurons from α-synuclein toxicity
Mickael Decressac et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB
Jose A. Martina et al.
AUTOPHAGY (2012)
A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB
Carmine Settembre et al.
EMBO JOURNAL (2012)
Mitochondrial metabolism in Parkinsons disease impairs quality control autophagy by hampering microtubule-dependent traffic
Daniela M. Arduino et al.
HUMAN MOLECULAR GENETICS (2012)
Microtubule-associated Protein 1 Light Chain 3 (LC3) Interacts with Bnip3 Protein to Selectively Remove Endoplasmic Reticulum and Mitochondria via Autophagy
Rita A. Hanna et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
An early age increase in vacuolar pH limits mitochondrial function and lifespan in yeast
Adam L. Hughes et al.
NATURE (2012)
The Transcription Factor TFEB Links mTORC1 Signaling to Transcriptional Control of Lysosome Homeostasis
Agnes Roczniak-Ferguson et al.
SCIENCE SIGNALING (2012)
PGC-1α Rescues Huntington's Disease Proteotoxicity by Preventing Oxidative Stress and Promoting TFEB Function
Taiji Tsunemi et al.
SCIENCE TRANSLATIONAL MEDICINE (2012)
Mitochondrial Quality Control Mediated by PINK1 and Parkin: Links to Parkinsonism
Derek Narendra et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2012)
Transcriptional Activation of Lysosomal Exocytosis Promotes Cellular Clearance
Diego L. Medina et al.
DEVELOPMENTAL CELL (2011)
Rotenone, Paraquat, and Parkinson's Disease
Caroline M. Tanner et al.
ENVIRONMENTAL HEALTH PERSPECTIVES (2011)
PINK1 cleavage at position A103 by the mitochondrial protease PARL
Emma Deas et al.
HUMAN MOLECULAR GENETICS (2011)
Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways
Michela Palmieri et al.
HUMAN MOLECULAR GENETICS (2011)
A novel recurrent mutation in MITF predisposes to familial and sporadic melanoma
Satoru Yokoyama et al.
NATURE (2011)
A SUMOylation-defective MITF germline mutation predisposes to melanoma and renal carcinoma
Corine Bertolotto et al.
NATURE (2011)
TFEB Links Autophagy to Lysosomal Biogenesis
Carmine Settembre et al.
SCIENCE (2011)
Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids
Yasemin Sancak et al.
CELL (2010)
Vps35 Mediates Vesicle Transport between the Mitochondria and Peroxisomes
Emelie Braschi et al.
CURRENT BIOLOGY (2010)
Mitochondrial respiration and respiration-associated proteins in cell lines created through Parkinson's subject mitochondrial transfer
A. Raquel Esteves et al.
JOURNAL OF NEUROCHEMISTRY (2010)
Rapamycin Protects against Neuron Death in In Vitro and In Vivo Models of Parkinson's Disease
Cristina Malagelada et al.
JOURNAL OF NEUROSCIENCE (2010)
Pathogenic Lysosomal Depletion in Parkinson's Disease
Benjamin Dehay et al.
JOURNAL OF NEUROSCIENCE (2010)
Trehalose ameliorates dopaminergic and tau pathology in parkin deleted/tau overexpressing mice through autophagy activation
Jose A. Rodriguez-Navarro et al.
NEUROBIOLOGY OF DISEASE (2010)
Inactivation of the FLCN Tumor Suppressor Gene Induces TFE3 Transcriptional Activity by Increasing Its Nuclear Localization
Seung-Beom Hong et al.
PLOS ONE (2010)
DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function
Ling-Yang Hao et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin
Derek P. Narendra et al.
PLOS BIOLOGY (2010)
PGC-1α, SIRT1 and AMPK, an energy sensing network that controls energy expenditure
Carles Canto et al.
CURRENT OPINION IN LIPIDOLOGY (2009)
Cybrid models of Parkinson's disease show variable mitochondrial biogenesis and genotype-respiration relationships
Paula M. Keeney et al.
EXPERIMENTAL NEUROLOGY (2009)
LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model
Javier Alegre-Abarrategui et al.
HUMAN MOLECULAR GENETICS (2009)
A highly reproducible rotenone model of Parkinson's disease
Jason R. Cannon et al.
NEUROBIOLOGY OF DISEASE (2009)
A Gene Network Regulating Lysosomal Biogenesis and Function
Marco Sardiello et al.
SCIENCE (2009)
Inhibition of mTOR Signaling in Parkinson's Disease Prevents L-DOPA-Induced Dyskinesia
Emanuela Santini et al.
SCIENCE SIGNALING (2009)
Immunosuppression Using the Mammalian Target of Rapamycin (mTOR) Inhibitor Everolimus: Pilot Study Shows Significant Cognitive and Affective Improvement
U. E. Lang et al.
TRANSPLANTATION PROCEEDINGS (2009)
Mitochondrial Function and Morphology Are Impaired in parkin-Mutant Fibroblasts
Heather Mortiboys et al.
ANNALS OF NEUROLOGY (2008)
Microphthalmia transcription factor regulates the expression of the novel osteoclast factor GPNMB
Vera M. Ripoll et al.
GENE (2008)
Gaucher disease:: Mutation and polymorphism spectrum in the glucocerebrosidase gene (GBA)
Kathleen S. Hruska et al.
HUMAN MUTATION (2008)
Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
Derek Narendra et al.
JOURNAL OF CELL BIOLOGY (2008)
PLA2G6, encoding a phospholipase A2, is mutated in neurodegenerative disorders with high brain iron
Neil V. Morgan et al.
NATURE GENETICS (2006)
Oncogenic MITF dysregulation in clear cell sarcoma: Defining the MiT family of human cancers
Ian J. Davis et al.
CANCER CELL (2006)
MITF: master regulator of melanocyte development and melanoma oncogene
Carmit Levy et al.
TRENDS IN MOLECULAR MEDICINE (2006)
Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma
LA Garraway et al.
NATURE (2005)
Transcription factor Tfec contributes to the IL-4-inducible expression of a small group of genes in mouse macrophages including the granulocyte colony-stimulating factor receptor
M Rehli et al.
JOURNAL OF IMMUNOLOGY (2005)
Glucocerebrosidase mutations in subjects with parkinsonism
A Lwin et al.
MOLECULAR GENETICS AND METABOLISM (2004)
Cytoplasmic transfer of platelet mtDNA from elderly patients with Parkinson's disease to mtDNA-less HeLa cells restores complete mitochondrial respiratory function
Y Aomi et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2001)
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