4.6 Article

CX3CR1 deficiency aggravates amyloid driven neuronal pathology and cognitive decline in Alzheimer's disease

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Clinical Neurology

Distinct amyloid-β and tau-associated microglia profiles in Alzheimer's disease

Emma Gerrits et al.

Summary: This study conducted single-nuclei RNA sequencing on Alzheimer's disease (AD)-related human microglia, revealing two distinct expression profiles associated with pathology. These findings shed light on the role of microglia in AD and offer new targets for microglia-specific therapeutic strategies.

ACTA NEUROPATHOLOGICA (2021)

Article Biochemistry & Molecular Biology

Multimodal single-cell/nucleus RNA sequencing data analysis uncovers molecular networks between disease-associated microglia and astrocytes with implications for drug repurposing in Alzheimer's disease

Jielin Xu et al.

Summary: This study identified novel therapeutic targets for Alzheimer's disease by analyzing molecular networks between DAM and DAA, revealing the potential roles of inflammation, immune pathways, and drugs in AD pathogenesis through integrative data analysis.

GENOME RESEARCH (2021)

Review Cell Biology

Possible Mechanisms of Tau Spread and Toxicity in Alzheimer's Disease

Huiqin Zhang et al.

Summary: Tau protein binds to microtubules to promote assembly and stability, but loses this ability in tauopathies, leading to pathological changes like AD. Evidence suggests that tauopathies can spread between cells or connected regions. The complex process involves multiple steps including secretion, cellular uptake, transcellular transfer, and seeding, but the exact mechanisms of tau pathology propagation remain unclear.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Review Neurosciences

δ-secretase in neurodegenerative diseases: mechanisms, regulators and therapeutic opportunities

Zhentao Zhang et al.

TRANSLATIONAL NEURODEGENERATION (2020)

Article Clinical Neurology

APOE and TREM2 regulate amyloid-responsive microglia in Alzheimer's disease

Aivi T. Nguyen et al.

ACTA NEUROPATHOLOGICA (2020)

Article Medicine, Research & Experimental

Impact of TREM2R47H variant on tau pathology-induced gliosis and neurodegeneration

Maud Gratuze et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

Review Immunology

Neuroinflammation and fractalkine signaling in Alzheimer's disease

Dylan J. Finneran et al.

JOURNAL OF NEUROINFLAMMATION (2019)

Article Immunology

The intracellular domain of CX3CL1 regulates adult neurogenesis and Alzheimer's amyloid pathology

Qingyuan Fan et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2019)

Article Biochemistry & Molecular Biology

Evidence for a protective role of the CX3CL1/CX3CR1 axis in a model of amyotrophic lateral sclerosis

Chang Liu et al.

BIOLOGICAL CHEMISTRY (2019)

Article Biology

Cx3cr1-deficient microglia exhibit a premature aging transcriptome

Stefka Gyoneva et al.

LIFE SCIENCE ALLIANCE (2019)

Review Neurosciences

Bidirectional Microglia-Neuron Communication in Health and Disease

Zsuzsanna Szepesi et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2018)

Review Biochemistry & Molecular Biology

Transforming Growth Factor Beta Type I Role in Neurodegeneration: Implications for Alzheimer's Disease

Lisbell D. Estrada et al.

CURRENT PROTEIN & PEPTIDE SCIENCE (2018)

Article Biochemistry & Molecular Biology

A Unique Microglia Type Associated with Restricting Development of Alzheimer's Disease

Hadas Keren-Shaul et al.

Article Biochemistry & Molecular Biology

The amyloid cascade hypothesis: are we poised for success or failure?

Eric Karran et al.

JOURNAL OF NEUROCHEMISTRY (2016)

Article Neurosciences

Microglial brain region-dependent diversity and selective regional sensitivities to aging

Kathleen Grabert et al.

NATURE NEUROSCIENCE (2016)

Article Multidisciplinary Sciences

Correlative Light and Electron Microscopy to Study Microglial Interactions with β-Amyloid Plaques

Kanchan Bisht et al.

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (2016)

Review Neurosciences

Alzheimer's Disease Risk Genes and Mechanisms of Disease Pathogenesis

Celeste M. Karch et al.

BIOLOGICAL PSYCHIATRY (2015)

Review Biochemistry & Molecular Biology

Receptors, Ion Channels, and Signaling Mechanisms Underlying Microglial Dynamics

Christian Madry et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2015)

Article Biotechnology & Applied Microbiology

Fractalkine Over Expression Suppresses alpha-Synuclein-mediated Neurodegeneration

Kevin R. Nash et al.

MOLECULAR THERAPY (2015)

Article Ophthalmology

Associations Between the T280M and V249I SNPs in CX3CR1 and the Risk of Age-Related Macular Degeneration

Rui Zhang et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2015)

Review Pharmacology & Pharmacy

Microglial dysfunction in brain aging and Alzheimer's disease

Kira Irving Mosher et al.

BIOCHEMICAL PHARMACOLOGY (2014)

Article Multidisciplinary Sciences

CX3CR1 Is a Modifying Gene of Survival and Progression in Amyotrophic Lateral Sclerosis

Alan Lopez-Lopez et al.

PLOS ONE (2014)

Review Neurosciences

Modulating neurotoxicity through CX3CL1/CX3CR1 signaling

Cristina Limatola et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2014)

Review Neurosciences

Molecular Mechanisms of Amyloid Oligomers Toxicity

Rakez Kayed et al.

JOURNAL OF ALZHEIMERS DISEASE (2013)

Article Neurosciences

Soluble Aβ Promotes Wild-Type Tau Pathology In Vivo

Meredith A. Chabrier et al.

JOURNAL OF NEUROSCIENCE (2012)

Article Multidisciplinary Sciences

Synaptic Pruning by Microglia Is Necessary for Normal Brain Development

Rosa C. Paolicelli et al.

SCIENCE (2011)

Review Biochemistry & Molecular Biology

Amyloid oligomers: formation and toxicity of A beta oligomers

Masafumi Sakono et al.

FEBS JOURNAL (2010)

Article Neurosciences

Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer's disease

Martin Fuhrmann et al.

NATURE NEUROSCIENCE (2010)

Article Neurosciences

Regulation of Tau Pathology by the Microglial Fractalkine Receptor

Kiran Bhaskar et al.

NEURON (2010)

Review Biochemistry & Molecular Biology

Structural Classification of Toxic Amyloid Oligomers

Charles G. Glabe

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Article Medicine, Research & Experimental

CX3CR1-dependent subretinal microglia cell accumulation is associated with cardinal features of age-related macular degeneration

Christophe Combadiere et al.

JOURNAL OF CLINICAL INVESTIGATION (2007)