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CANCER CELL (2013)
Cidofovir: A Novel Antitumor Agent for Glioblastoma
Piotr Hadaczek et al.
CLINICAL CANCER RESEARCH (2013)
ATM Kinase Inhibition Preferentially Sensitizes p53-Mutant Glioma to Ionizing Radiation
Laura Biddlestone-Thorpe et al.
CLINICAL CANCER RESEARCH (2013)
Glioma-amplified sequence KUB3 influences double-strand break repair after ionizing radiation
Ulrike Fischer et al.
INTERNATIONAL JOURNAL OF ONCOLOGY (2013)
Modelling of cell killing due to sparsely ionizing radiation in normoxic and hypoxic conditions and an extension to high LET radiation
Andrea Mairani et al.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2013)
Preclinical evaluation of radiosensitizing activity of Pluronic block copolymers
Reshani H. Perera et al.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2013)
Increased Subventricular Zone Radiation Dose Correlates With Survival in Glioblastoma Patients After Gross Total Resection
Linda Chen et al.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2013)
Prognostic value of Musashi-1 in gliomas
Rikke H. Dahlrot et al.
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C1q-tumour necrosis factor-related protein 8 (CTRP8) is a novel interaction partner of relaxin receptor RXFP1 in human brain cancer cells
Aleksandra Glogowska et al.
JOURNAL OF PATHOLOGY (2013)
Secondary mutations in BRCA2 associated with clinical resistance to a PARP inhibitor
Louise J. Barber et al.
JOURNAL OF PATHOLOGY (2013)
ATM- and ATR-Mediated Phosphorylation of XRCC3 Regulates DNA Double-Strand Break-Induced Checkpoint Activation and Repair
Kumar Somyajit et al.
MOLECULAR AND CELLULAR BIOLOGY (2013)
Contribution of ATM and ATR to the Resistance of Glioblastoma and Malignant Melanoma Cells to the Methylating Anticancer Drug Temozolomide
Marcus Eich et al.
MOLECULAR CANCER THERAPEUTICS (2013)
A Cell Cycle-Dependent Regulatory Circuit Composed of 53BP1-RIF1 and BRCA1-CtIP Controls DNA Repair Pathway Choice
Cristina Escribano-Diaz et al.
MOLECULAR CELL (2013)
Replication Stress and Chromatin Context Link ATM Activation to a Role in DNA Replication
Monica M. Olcina et al.
MOLECULAR CELL (2013)
Ionizing radiation-induced gene expression changes in TP53 proficient and deficient glioblastoma cell lines
P. R. D. V. Godoy et al.
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS (2013)
Organotypic slice cultures of human glioblastoma reveal different susceptibilities to treatments
Felicitas Merz et al.
NEURO-ONCOLOGY (2013)
Activation of the phosphorylation of ATM contributes to radioresistance of glioma stem cells
Wei Zhou et al.
ONCOLOGY REPORTS (2013)
The radiosensitization effect of titanate nanotubes as a new tool in radiation therapy for glioblastoma: A proof-of-concept
C. Mirjolet et al.
RADIOTHERAPY AND ONCOLOGY (2013)
Valosin-containing protein regulates the proteasome-mediated degradation of DNA-PKcs in glioma cells
N. Jiang et al.
CELL DEATH & DISEASE (2013)
Retinoblastoma protein regulates the crosstalk between autophagy and apoptosis, and favors glioblastoma resistance to etoposide
D. Biasoli et al.
CELL DEATH & DISEASE (2013)
The Interaction of CtIP and Nbs1 Connects CDK and ATM to Regulate HR-Mediated Double-Strand Break Repair
Hailong Wang et al.
PLOS GENETICS (2013)
Novel functions of FoxM1: from molecular mechanisms to cancer therapy
Monica Alvarez-Fernandez et al.
FRONTIERS IN ONCOLOGY (2013)
Upregulation of Drug Transporter Expression by Osteopontin in Prostate Cancer Cells
I-Shan Hsieh et al.
MOLECULAR PHARMACOLOGY (2013)
Cleavage of Atg3 protein by caspase-8 regulates autophagy during receptor-activated cell death
Ozlem Oral et al.
APOPTOSIS (2012)
Addressing Diffuse Glioma as a Systemic Brain Disease With Single-Cell Analysis
Felix Sahm et al.
ARCHIVES OF NEUROLOGY (2012)
Replication fork dynamics and the DNA damage response
Rebecca M. Jones et al.
BIOCHEMICAL JOURNAL (2012)
A role of DNA-dependent protein kinase for the activation of AMP-activated protein kinase in response to glucose deprivation
Parmeshwar Narayan Amatya et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2012)
Characterization of Glioma Stem Cells Through Multiple Stem Cell Markers and Their Specific Sensitization to Double-Strand Break-Inducing Agents by Pharmacological Inhibition of Ataxia Telangiectasia Mutated Protein
Alessandro Raso et al.
BRAIN PATHOLOGY (2012)
Conditional Probability of Long-Term Survival in Glioblastoma A Population-Based Analysis
Derek R. Johnson et al.
CANCER (2012)
Further characterisation of the cellular activity of the DNA-PK inhibitor, NU7441, reveals potential cross-talk with homologous recombination
Michele Tavecchio et al.
CANCER CHEMOTHERAPY AND PHARMACOLOGY (2012)
RNAi-Mediated Targeting of Noncoding and Coding Sequences in DNA Repair Gene Messages Efficiently Radiosensitizes Human Tumor Cells
Zhiming Zheng et al.
CANCER RESEARCH (2012)
Translation Initiation Factor eIF4E Is a Target for Tumor Cell Radiosensitization
Thomas J. Hayman et al.
CANCER RESEARCH (2012)
mTOR Signaling in Growth Control and Disease
Mathieu Laplante et al.
CELL (2012)
Dynamic inhibition of ATM kinase provides a strategy for glioblastoma multiforme radiosensitization and growth control
Sarah E. Golding et al.
CELL CYCLE (2012)
Exo1 plays a major role in DNA end resection in humans and influences double-strand break repair and damage signaling decisions
Nozomi Tomimatsu et al.
DNA REPAIR (2012)
Nutrient deprivation regulates DNA damage repair in cardiomyocytes via loss of the base-excision repair enzyme OGG1
Lee Siggens et al.
FASEB JOURNAL (2012)
Pharmacological concentrations of ascorbate radiosensitize glioblastoma multiforme primary cells by increasing oxidative DNA damage and inhibiting G2/M arrest
Patries M. Herst et al.
FREE RADICAL BIOLOGY AND MEDICINE (2012)
Three-dimensional Invasion of Human Glioblastoma Cells Remains Unchanged by X-ray and Carbon Ion Irradiation In Vitro
Iris Eke et al.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2012)
Gefitinib Radiosensitizes Stem-Like Glioma Cells: Inhibition of Epidermal Growth Factor Receptor-Akt-DNA-PK Signaling, Accompanied by Inhibition of DNA Double-Strand Break Repair
Khong Bee Kang et al.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2012)
Autophagosomal Membrane Serves as Platform for Intracellular Death-inducing Signaling Complex (iDISC)-mediated Caspase-8 Activation and Apoptosis
Megan M. Young et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Resveratrol suppresses tumorigenicity and enhances radiosensitivity in primary glioblastoma tumor initiating cells by inhibiting the STAT3 axis
Yi-Ping Yang et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2012)
ATM inhibitor KU-55933 increases the TMZ responsiveness of only inherently TMZ sensitive GBM cells
Aditi Nadkarni et al.
JOURNAL OF NEURO-ONCOLOGY (2012)
Cell survival, DNA damage, and oncogenic transformation after a transient and reversible apoptotic response
Ho Lam Tang et al.
MOLECULAR BIOLOGY OF THE CELL (2012)
A Role for Homologous Recombination and Abnormal Cell-Cycle Progression in Radioresistance of Glioma-Initiating Cells
Yi Chieh Lim et al.
MOLECULAR CANCER THERAPEUTICS (2012)
Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma
Jeremy Schwartzentruber et al.
NATURE (2012)
Glioblastoma resistance to anti-VEGF therapy is associated with myeloid cell infiltration, stem cell accumulation, and a mesenchymal phenotype
Yuji Piao et al.
NEURO-ONCOLOGY (2012)
Oncogenic YAP promotes radioresistance and genomic instability in medulloblastoma through IGF2-mediated Akt activation
A. Fernandez-L et al.
ONCOGENE (2012)
Distribution and Radiosensitizing Effect of Cholesterol-Coupled Dbait Molecule in Rat Model of Glioblastoma
Nicolas Coquery et al.
PLOS ONE (2012)
DNMT (DNA methyltransferase) inhibitors radiosensitize human cancer cells by suppressing DNA repair activity
Hak Jae Kim et al.
RADIATION ONCOLOGY (2012)
Structural Basis for DNA Damage-Dependent Poly(ADP-ribosyl)ation by Human PARP-1
Marie-France Langelier et al.
SCIENCE (2012)
Combining a PI3K Inhibitor with a PARP Inhibitor Provides an Effective Therapy for BRCA1-Related Breast Cancer
Ashish Juvekar et al.
CANCER DISCOVERY (2012)
The Brain Microenvironment Preferentially Enhances the Radioresistance of CD133+ Glioblastoma Stem-like Cells
Muhammad Jamal et al.
NEOPLASIA (2012)
Knockdown of the DNA-dependent protein kinase catalytic subunit radiosensitizes glioma-initiating cells by inducing autophagy
Wenzhuo Zhuang et al.
BRAIN RESEARCH (2011)
Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases
Wei Xu et al.
CANCER CELL (2011)
ASPM influences DNA double-strand break repair and represents a potential target for radiotherapy
Takamitsu A. Kato et al.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2011)
Inactivation of ataxia telangiectasia mutated gene can increase intracellular reactive oxygen species levels and alter radiation-induced cell death pathways in human glioma cells
Shu-Chi Wang et al.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2011)
Radiosensitization of glioma cells by modulation of Met signalling with the hepatocyte growth factor neutralizing antibody, AMG102
Ian M. Buchanan et al.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2011)
Contribution of Decreased Expression of Ku70 to Enhanced Radiosensitivity by Sodium Butyrate in Glioblastoma Cell Line (U251)
Yuhui Li et al.
JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY-MEDICAL SCIENCES (2011)
Artesunate Induces Oxidative DNA Damage, Sustained DNA Double-Strand Breaks, and the ATM/ATR Damage Response in Cancer Cells
Nicole Berdelle et al.
MOLECULAR CANCER THERAPEUTICS (2011)
The underlying mechanism for the PARP and BRCA synthetic lethality: Clearing up the misunderstandings
Thomas Helleday
MOLECULAR ONCOLOGY (2011)
HDACs link the DNA damage response, processing of double-strand breaks and autophagy
Thomas Robert et al.
NATURE (2011)
The ubiquitin-selective segregase VCP/p97 orchestrates the response to DNA double-strand breaks
Mayura Meerang et al.
NATURE CELL BIOLOGY (2011)
The resistance of DMC1 D-loops to dissociation may account for the DMC1 requirement in meiosis
Dmitry V. Bugreev et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2011)
Rad51 inhibition is an effective means of targeting DNA repair in glioma models and CD133+tumor-derived cells
Susan C. Short et al.
NEURO-ONCOLOGY (2011)
Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions
Guo-li Ming et al.
NEURON (2011)
Validation of an amino-acid-based radionuclide therapy plus external beam radiotherapy in heterotopic glioblastoma models
Ina Israel et al.
NUCLEAR MEDICINE AND BIOLOGY (2011)
Certain Imidazotetrazines Escape O6-Methylguanine-DNA Methyltransferase and Mismatch Repair
Jihong Zhang et al.
ONCOLOGY (2011)
Microsatellite Instability in Pediatric High Grade Glioma Is Associated with Genomic Profile and Differential Target Gene Inactivation
Marta Viana-Pereira et al.
PLOS ONE (2011)
Rad51 and BRCA2-New Molecular Targets for Sensitizing Glioma Cells to Alkylating Anticancer Drugs
Steve Quiros et al.
PLOS ONE (2011)
Regulation of DNA Repair Mechanism in Human Glioma Xenograft Cells both In Vitro and In Vivo in Nude Mice
Shivani Ponnala et al.
PLOS ONE (2011)
The mTOR Inhibitor Rapamycin Suppresses DNA Double-Strand Break Repair
Honghong Chen et al.
RADIATION RESEARCH (2011)
Survivin inhibition and DNA double-strand break repair: A molecular mechanism to overcome radioresistance in glioblastoma
Sebastian Reichert et al.
RADIOTHERAPY AND ONCOLOGY (2011)
Altered Telomeres in Tumors with ATRX and DAXX Mutations
Christopher M. Heaphy et al.
SCIENCE (2011)
PARP inhibition sensitizes childhood high grade glioma, medulloblastoma and ependymoma to radiation
Dannis G. van Vuurden et al.
ONCOTARGET (2011)
Release of Ku and MRN from DNA Ends by Mre11 Nuclease Activity and Ctp1 Is Required for Homologous Recombination Repair of Double-Strand Breaks
Petra Langerak et al.
PLOS GENETICS (2011)
Celecoxib-induced apoptosis is enhanced by ABT-737 and by inhibition of autophagy in human colorectal cancer cells
Shengbing Huang et al.
AUTOPHAGY (2010)
Autophagic degradation of active caspase-8 A crosstalk mechanism between autophagy and apoptosis
Wen Hou et al.
AUTOPHAGY (2010)
Mitochondrial autophagy protects against heat shock-induced apoptosis through reducing cytosolic cytochrome c release and downstream caspase-3 activation
Ying Yang et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2010)
Irradiation of the potential cancer stem cell niches in the adult brain improves progression-free survival of patients with malignant glioma
Patrick Evers et al.
BMC CANCER (2010)
Identification of Potential Serum Biomarkers of Glioblastoma: Serum Osteopontin Levels Correlate with Poor Prognosis
Peddagangannagari Sreekanthreddy et al.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION (2010)
Grade-Specific Expression of Insulin-like Growth Factor-Binding Proteins-2,-3, and-5 in Astrocytomas: IGFBP-3 Emerges as a Strong Predictor of Survival in Patients with Newly Diagnosed Glioblastoma
Vani Santosh et al.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION (2010)
Resveratrol induces DNA double-strand breaks through human topoisomerase II interaction
Stefano Leone et al.
CANCER LETTERS (2010)
PTEN Loss Compromises Homologous Recombination Repair in Astrocytes: Implications for Glioblastoma Therapy with Temozolomide or Poly(ADP-Ribose) Polymerase Inhibitors
Brian McEllin et al.
CANCER RESEARCH (2010)
DNA ligase IV is a potential molecular target in ACNU sensitivity
Natsuko Kondo et al.
CANCER SCIENCE (2010)
Gamma-radiation sensitivity and polymorphisms in RAD51L1 modulate glioma risk
Yanhong Liu et al.
CARCINOGENESIS (2010)
Microenvironmental Regulation of Glioblastoma Radioresponse
Muhammad Jamal et al.
CLINICAL CANCER RESEARCH (2010)
Autophagy regulation by p53
Maria Chiara Maiuri et al.
CURRENT OPINION IN CELL BIOLOGY (2010)
Radiation-Induced Micro-RNA Modulation in Glioblastoma Cells Differing in DNA-Repair Pathways
M. Ahmad Chaudhry et al.
DNA AND CELL BIOLOGY (2010)
DNA-PKcs deficiency leads to persistence of oxidatively induced clustered DNA lesions in human tumor cells
Prakash Peddi et al.
FREE RADICAL BIOLOGY AND MEDICINE (2010)
Amplicons on chromosome 12q13-21 in glioblastoma recurrences
Ulrike Fischer et al.
INTERNATIONAL JOURNAL OF CANCER (2010)
Polymorphisms of LIG4, BTBD2, HMGA2, and RTEL1 Genes Involved in the Double-Strand Break Repair Pathway Predict Glioblastoma Survival
Yanhong Liu et al.
JOURNAL OF CLINICAL ONCOLOGY (2010)
The frequency of NBN molecular variants in pediatric astrocytic tumors
Dorota Piekutowska-Abramczuk et al.
JOURNAL OF NEURO-ONCOLOGY (2010)
BMI1 Confers Radioresistance to Normal and Cancerous Neural Stem Cells through Recruitment of the DNA Damage Response Machinery
Sabrina Facchino et al.
JOURNAL OF NEUROSCIENCE (2010)
Accumulation of CD 133-positive glioma cells after high-dose irradiation by Gamma Knife surgery plus external beam radiation Clinical article
Kaoru Tamura et al.
JOURNAL OF NEUROSURGERY (2010)
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate (vol 462, pg 739, 2010)
Lenny Dang et al.
NATURE (2010)
53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers
Peter Bouwman et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2010)
mTOR signaling in glioblastoma: lessons learned from bench to bedside
David Akhavan et al.
NEURO-ONCOLOGY (2010)
The alternative end-joining pathway for repair of DNA double-strand breaks requires PARP1 but is not dependent upon microhomologies
Wael Y. Mansour et al.
NUCLEIC ACIDS RESEARCH (2010)
Defective DNA double-strand break repair underlies enhanced tumorigenesis and chromosomal instability in p27-deficient mice with growth factor-induced oligodendrogliomas
W. L. See et al.
ONCOGENE (2010)
Replication stress and oxidative damage contribute to aberrant constitutive activation of DNA damage signalling in human gliomas
J. Bartkova et al.
ONCOGENE (2010)
Regulation of DNA-dependent protein kinase by protein kinase CK2 in human glioblastoma cells
B. B. Olsen et al.
ONCOGENE (2010)
Participation of DNA-PKcs in DSB Repair after Exposure to High- and Low-LET Radiation
Jennifer A. Anderson et al.
RADIATION RESEARCH (2010)
DNA damage and decisions: CtIP coordinates DNA repair and cell cycle checkpoints
Zhongsheng You et al.
TRENDS IN CELL BIOLOGY (2010)
PARP inhibition: PARP1 and beyond
Michele Rouleau et al.
NATURE REVIEWS CANCER (2010)
Expression patterns of Neil3 during embryonic brain development and neoplasia
Gunn A. Hildrestrand et al.
BMC NEUROSCIENCE (2009)
Recent Advances in Cancer Therapy Targeting Proteins Involved in DNA Double-Strand Break Repair
Emma Bolderson et al.
CLINICAL CANCER RESEARCH (2009)
CD133+ Glioblastoma Stem-like Cells are Radiosensitive with a Defective DNA Damage Response Compared with Established Cell Lines
Amy M. McCord et al.
CLINICAL CANCER RESEARCH (2009)
Brca2/Xrcc2 dependent HR, but not NHEJ, is required for protection against O-6-methylguanine triggered apoptosis, DSBs and chromosomal aberrations by a process leading to SCEs
Wynand P. Roos et al.
DNA REPAIR (2009)
Mre11 inhibition by oncolytic adenovirus associates with autophagy and underlies synergy with ionizing radiation
Maria Rajecki et al.
INTERNATIONAL JOURNAL OF CANCER (2009)
INDUCTION OF DNA DOUBLE-STRAND BREAKS AND CELLULAR MIGRATION THROUGH BYSTANDER EFFECTS IN CELLS IRRADIATED WITH THE SLIT-TYPE MICROPLANAR BEAM OF THE SPRING-8 SYNCHROTRON
Genro Kashino et al.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2009)
Human CtIP Mediates Cell Cycle Control of DNA End Resection and Double Strand Break Repair
Pablo Huertas et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Mutational Inactivation of the Nijmegen Breakage Syndrome Gene (NBS1) in Glioblastomas Is Associated With Multiple TP53 Mutations
Takuya Watanabe et al.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2009)
BMI1 Sustains Human Glioblastoma Multiforme Stem Cell Renewal
Mohamed Abdouh et al.
JOURNAL OF NEUROSCIENCE (2009)
Comparative Analysis of DNA Repair in Stem and Nonstem Glioma Cell Cultures
Monica Ropolo et al.
MOLECULAR CANCER RESEARCH (2009)
Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion
Sarah E. Golding et al.
MOLECULAR CANCER THERAPEUTICS (2009)
RAD18 transmits DNA damage signalling to elicit homologous recombination repair
Jun Huang et al.
NATURE CELL BIOLOGY (2009)
Characterization of novel and complex genomic aberrations in glioblastoma using a 32K BAC array
Helena Nord et al.
NEURO-ONCOLOGY (2009)
IDH1 and IDH2 Mutations in Gliomas
Hai Yan et al.
NEW ENGLAND JOURNAL OF MEDICINE (2009)
The pyridinylfuranopyrimidine inhibitor, PI-103, chemosensitizes glioblastoma cells for apoptosis by inhibiting DNA repair
M-A Westhoff et al.
ONCOGENE (2009)
Hyperactivation of DNA-PK by Double-Strand Break Mimicking Molecules Disorganizes DNA Damage Response
Maria Quanz et al.
PLOS ONE (2009)
PARP1 Expression in Pediatric Central Nervous System Tumors
Valerie N. Barton et al.
PEDIATRIC BLOOD & CANCER (2009)
The c-Met receptor tyrosine kinase inhibitor MP470 radiosensitizes glioblastoma cells
James W. Welsh et al.
RADIATION ONCOLOGY (2009)
Loss of ATM Impairs Proliferation of Neural Stem Cells Through Oxidative Stress-Mediated p38 MAPK Signaling
Jeesun Kim et al.
STEM CELLS (2009)
Distinct roles of Topoisomerase II isoforms:: DNA damage accelerating α, double strand break repair promoting β
Raj Kumar Mandraju et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2008)
Ionizing radiation downregulates ASPM, a gene responsible for microcephaly in humans
Akira Fujimori et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2008)
Protective role of Purα to cisplatin
Rafal Kaminski et al.
CANCER BIOLOGY & THERAPY (2008)
Glycogen synthase kinase-3 inhibition induces glioma cell death through c-MYC, nuclear factor-κB, and glucose regulation
Svetlana Kotliarova et al.
CANCER RESEARCH (2008)
Vascular endothelial growth factor receptor-1 contributes to resistance to anti-epidermal growth factor receptor drugs in human cancer cells
Roberto Bianco et al.
CLINICAL CANCER RESEARCH (2008)
Modulation of the DNA-damage response to HZE particles by shielding
Bipasha Mukherjee et al.
DNA REPAIR (2008)
The Yku70-Yku80 complex contributes to regulate double-strand break processing and checkpoint activation during the cell cycle
Michela Clerici et al.
EMBO REPORTS (2008)
CD133 negative glioma cells form tumors in nude rats and give rise to CD133 positive cells
Jian Wang et al.
INTERNATIONAL JOURNAL OF CANCER (2008)
Constitutive phosphorylation of MDC1 physically links the MRE11-RAD50-NBS1 complex to damaged chromatin
Christoph Spycher et al.
JOURNAL OF CELL BIOLOGY (2008)
PARP-1 ensures regulation of replication fork progression by homologous recombination on damaged DNA
Kazuto Sugimura et al.
JOURNAL OF CELL BIOLOGY (2008)
Involvement of miltefosine-mediated ERK activation in glioma cell apoptosis through Fas regulation
Richa Tewari et al.
JOURNAL OF NEUROCHEMISTRY (2008)
DNA-dependent protein kinase catalytic subunit modulates the stability of c-Myc oncoprotein
Jing An et al.
MOLECULAR CANCER (2008)
Resistance to therapy caused by intragenic deletion in BRCA2
Stacey L. Edwards et al.
NATURE (2008)
Comprehensive genomic characterization defines human glioblastoma genes and core pathways
L. Chin et al.
NATURE (2008)
CD133 Is a Marker of Bioenergetic Stress in Human Glioma
Corinne E. Griguer et al.
PLOS ONE (2008)
An integrated genomic analysis of human glioblastoma Multiforme
D. Williams Parsons et al.
SCIENCE (2008)
Maternal embryonic leucine zipper kinase transcript abundance correlates with malignancy grade in human astrocytomas
Suely K. N. Marie et al.
INTERNATIONAL JOURNAL OF CANCER (2008)
Molecular and cellular response of the most extensively used rodent glioma models to radiation and/or cisplatin
Zuzana Bencokova et al.
JOURNAL OF NEURO-ONCOLOGY (2008)
Differential sensitivity of malignant glioma cells to methylating and chloroethylating anticancer drugs:: p53 determines the switch by regulating xpc, ddb2, and DNA double-strand breaks
Luis F. Z. Batista et al.
CANCER RESEARCH (2007)
Activation and regulation of ATM kinase activity in response to DNA double-strand breaks
J-H Lee et al.
ONCOGENE (2007)
Autocrine factors that sustain glioma invasion and paracrine biology in the brain microenvironment
Dominique B. Hoelzinger et al.
JOURNAL OF THE NATIONAL CANCER INSTITUTE (2007)
Differential interactions between Beclin 1 and bcl-2 family members
Shlomit Erlich et al.
AUTOPHAGY (2007)
DNA repair after irradiation in glioma cells and normal human astrocytes
Susan C. Short et al.
NEURO-ONCOLOGY (2007)
Bmi1 controls tumor development in an ink4a/Arf-independent manner in a mouse model for glioma
Sophia W. M. Bruggeman et al.
CANCER CELL (2007)
Identification and biological evaluation of a novel and potent small molecule radiation sensitizer via an unbiased screen of a chemical library
Brian E. Lally et al.
CANCER RESEARCH (2007)
Mre11-Rad50-Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin template
R. Scott Williams et al.
BIOCHEMISTRY AND CELL BIOLOGY (2007)
CD133+ and CD133- glioblastoma-derived cancer stem cells show differential growth characteristics and molecular profiles
Dagmar Beier et al.
CANCER RESEARCH (2007)
Genetic pathways to primary and secondary glioblastoma
Hiroko Ohgaki et al.
AMERICAN JOURNAL OF PATHOLOGY (2007)
Evidence for the involvement of Purα in response to DNA replication stress
Huichen Wang et al.
CANCER BIOLOGY & THERAPY (2007)
DNA mismatch repair initiates 6-thioguanine-induced autophagy through p53 activation in human tumor cells
Xuehuo Zeng et al.
CLINICAL CANCER RESEARCH (2007)
PARP-3 associates with polycomb group bodies and with components of the DNA damage repair machinery
M. Rouleau et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2007)
Apoptosis in malignant glioma cells triggered by the temozolomide-induced DNA lesion O-6-methylguanine
W. P. Roos et al.
ONCOGENE (2007)
Regulation of reactive oxygen species by Atm is essential for proper response to DNA double-strand breaks in lymphocytes
Keisuke Ito et al.
JOURNAL OF IMMUNOLOGY (2007)
DRAM links autophagy to p53 and programmed cell death
Diane Crighton et al.
AUTOPHAGY (2007)
Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
Shideng Bao et al.
NATURE (2006)
Analysis of oncogenic signaling networks in glioblastoma identifies ASPM as a molecular target
S. Horvath et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
In vitro and in vivo potentiating the cytotoxic effect of radiation on human U251 gliomas by the c-Met antisense oligodeoxynucleotides
Sheng-hua Chu et al.
JOURNAL OF NEURO-ONCOLOGY (2006)
Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis
Shida Yousefi et al.
NATURE CELL BIOLOGY (2006)
ATR dependent activation of Chk2
Xiao Qi Wang et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2006)
c-Met ectodomain shedding rate correlates with malignant potential
Gagani Athauda et al.
CLINICAL CANCER RESEARCH (2006)
DRAM, a p53-induced modulator of autophagy, is critical for apoptosis
Diane Crighton et al.
CELL (2006)
FoxM1B is overexpressed in human glioblastomas and critically regulates the tumorigenicity of glioma cells
MG Liu et al.
CANCER RESEARCH (2006)
Parp-1 protects homologous recombination from interference by Ku and ligase IV in vertebrate cells
H Hochegger et al.
EMBO JOURNAL (2006)
Multiple but dissectible functions of FEN-1 nucleases in nucleic acid processing, genome stability and diseases
BH Shen et al.
BIOESSAYS (2005)
Targeting the c-Met pathway potentiates glioblastoma responses to γ-radiation
BC Lal et al.
CLINICAL CANCER RESEARCH (2005)
Essential roles of Atg5 and FADD in autophagic cell death - Dissection of autophagic cell death into vacuole formation and cell death
JO Pyo et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Inhibition of the DNA-dependent protein kinase catalytic subunit radiosensitizes malignant gliorna cells by inducing autophagy
S Daido et al.
CANCER RESEARCH (2005)
Enhancement of in vitro and in vivo tumor cell radiosensitivity by valproic acid
K Camphausen et al.
INTERNATIONAL JOURNAL OF CANCER (2005)
MGMT gene silencing and benefit from temozolomide in glioblastoma
ME Hegi et al.
NEW ENGLAND JOURNAL OF MEDICINE (2005)
Different G2/M accumulation in M059J and M059K cells after exposure to DNA double-strand break-inducing agents
Å Holgersson et al.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2005)
ATM signaling and genornic stability in response to DNA damage
MF Lavin et al.
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2005)
Functional interaction of H2AX, NBS1, and p53 in ATM-dependent DNA damage responses and tumor suppression
J Kang et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
Double strand break repair by homologous recombination is regulated by cell cycle-independent signaling via ATM in human glioma cells
SE Golding et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Cure of fisher rats bearing radioresistant F98 glioma treated with cis-platinum and irradiated with monochromatic synchrotron X-rays
MC Biston et al.
CANCER RESEARCH (2004)
Microarray analysis of temporal gene responses to ionizing radiation in two glioblastoma cell lines: Up-regulation of DNA repair genes
T Otomo et al.
JOURNAL OF RADIATION RESEARCH (2004)
P53 inhibits strand exchange and replication fork regression promoted by human rad51
D Yoon et al.
JOURNAL OF MOLECULAR BIOLOGY (2004)
Survivin enhances radiation resistance in primary human glioblastoma cells via caspase-independent mechanisms
A Chakravarti et al.
ONCOGENE (2004)
Stem colls and cancer: The polycomb connection
ME Valk-Lingbeek et al.
CELL (2004)
Polymorphisms of DNA repair genes and risk of glioma
LE Wang et al.
CANCER RESEARCH (2004)
The prognostic significance of phosphatidylinositol 3-kinase pathway activation in human gliomas
A Chakravarti et al.
JOURNAL OF CLINICAL ONCOLOGY (2004)
Time and dose-dependent radiosensitization of the glioblastoma multiforme U251 cells by the EGF receptor tyrosine kinase inhibitor ZD 1839 ('Iressa')
B Stea et al.
CANCER LETTERS (2003)
Inhibition of DNA repair for sensitizing resistant glioma cells to temozolomide
T Kanzawa et al.
JOURNAL OF NEUROSURGERY (2003)
The interacting pathways for prevention and repair of oxidative DNA damage
G Slupphaug et al.
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2003)
Mechanism and regulation of human non-homologous DNA end-joining
MR Lieber et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2003)
The immunosuppressant mycophenolate mofetil attenuates neuronal damage after excitotoxic injury in hippocampal slice cultures
F Dehghani et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2003)
EGFRvIII-mediated radioresistance through a strong cytoprotective response
G Lammering et al.
ONCOGENE (2003)
An inflatable balloon catheter and liquid 125I radiation source (GliaSite Radiation Therapy System) for treatment of recurrent malignant glioma:: multicenter safety and feasibility trial
SB Tatter et al.
JOURNAL OF NEUROSURGERY (2003)
Pathways of DNA double-strand break repair during the mammalian cell cycle
K Rothkamm et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
Low and high LET radiation-induced apoptosis in M059J and M059K cells
Å Holgersson et al.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2003)
Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells
IK Park et al.
NATURE (2003)
Adaptive responses in human glioma cells assessed by clonogenic survival and DNA strand break analysis
DM Smith et al.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2003)
Radiation stimulates HGF receptor/c-Met expression that leads to amplifying cellular response to HGF stimulation via upregulated receptor tyrosine phosphorylation and map kinase activity in pancreatic cancer cells
LW Qian et al.
INTERNATIONAL JOURNAL OF CANCER (2003)
Molecular response of human glioblastoma multiforme cells to ionizing radiation: cell cycle arrest, modulation of the expression of cyclin-dependent kinase inhibitors, and autophagy
KC Yao et al.
JOURNAL OF NEUROSURGERY (2003)
Role of DNA-PK in the process of aberration formation as studied in irradiated human glioblastoma cell lines M059K and M059J
P Virsik-Kopp et al.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2003)
Repair of DNA double strand breaks by non-homologous end joining
SP Lees-Miller et al.
BIOCHIMIE (2003)
IL-13Rα2 is a glioma-restricted receptor for interleukin-13
A Mintz et al.
NEOPLASIA (2002)
DNA damage-induced apoptosis requires the DNA-dependent protein kinase, and is mediated by the latent population of p53
RA Woo et al.
EMBO JOURNAL (2002)
Roles of DNA-dependent protein kinase and ATM in cell-cycle-dependent radiation sensitivity in human cells
M Yoshida et al.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2002)
Phosphorothioate oligonucleotides, suramin and heparin inhibit DNA-dependent protein kinase activity
Y Hosoi et al.
BRITISH JOURNAL OF CANCER (2002)
Survival and failure patterns of high-grade gliomas after three-dimensional conformal radiotherapy
JL Chan et al.
JOURNAL OF CLINICAL ONCOLOGY (2002)
PTEN protects p53 from Mdm2 and sensitizes cancer cells to chemotherapy
LD Mayo et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Quantitatively determined survivin expression levels are of prognostic value in human gliomas
A Chakravarti et al.
JOURNAL OF CLINICAL ONCOLOGY (2002)
Sensing of intermediates in V(D)J recombination by ATM
EJ Perkins et al.
GENES & DEVELOPMENT (2002)
Progenitor cells and glioma formation
EC Holland
CURRENT OPINION IN NEUROLOGY (2001)
Growth inhibition of glioblastoma cells by human Purα
N Darbinian et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2001)
ATM phosphorylates histone H2AX in response to DNA double-strand breaks
S Burma et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Adenovirus-mediated overexpression of dominant negative epidermal growth factor receptor-CD533 as a gene therapeutic approach radiosensitizes human carcinoma and malignant glioma cells
G Lammering et al.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2001)
γ-radiation sensitivity and risk of glioma
ML Bondy et al.
JOURNAL OF THE NATIONAL CANCER INSTITUTE (2001)
Glutamate release promotes growth of malignant gliomas
T Takano et al.
NATURE MEDICINE (2001)
High susceptibility of Scid mice to colon carcinogenesis induced by azoxymethane indicates a possible caretaker role for DNA-dependent protein kinase
M Ochiai et al.
CARCINOGENESIS (2001)
ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1
H Zhao et al.
MOLECULAR AND CELLULAR BIOLOGY (2001)
Reduced DNA-dependent protein kinase activity is associated with lung cancer
DH Auckley et al.
CARCINOGENESIS (2001)
DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme?
D Durocher et al.
CURRENT OPINION IN CELL BIOLOGY (2001)
Wortmannin sensitizes human glioblastoma cell lines carrying mutant and wild type TP53 gene to radiation
N Kubota et al.
CANCER LETTERS (2000)
The many substrates and functions of ATM
MB Kastan et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2000)
Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro
S Matsuoka et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage
TT Paull et al.
CURRENT BIOLOGY (2000)
Repair of O6-alkylguanine by alkyltransferases
AE Pegg
MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH (2000)
DNA double strand break repair in mammalian cells
P Karran
CURRENT OPINION IN GENETICS & DEVELOPMENT (2000)
Preliminary report of a phase I study of combined fractionated stereotactic radiosurgery and conventional external beam radiation therapy for unfavorable gliomas
WF Regine et al.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2000)
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